Human Anti-CD70 (clone 2H5) scFv-Fc Chimera

CAT#: VS-0325-FY72

Anti-CD70 scFv-Fc is a recombinant antibody that binds to CD70, a protein found on some cancer cells. It's made by fusing a single-chain variable fragment (scFv) to the Fc region of an immunoglobulin.

Gene Expression
Figure 1 IF staining of human cell line SiHa Figure 2 IF staining of human cell line U-251 MG Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)

Specifications

  • Immunogen
  • Recombinant human CD70
  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human CD70
  • Species Reactivity
  • Human
  • Clone
  • 2H5
  • Applications
  • Flow Cytometry, ELISA, Immunohistochemistry, Blocking
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • Flow Cytometry: 1 μg/mL

Target

  • Alternative Names
  • CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L; TNFRSF27
  • Long Name
  • CD70 Molecule
  • Sequence Similarities
  • Belongs to the tumor necrosis factor family.
  • Cellular Localization
  • Membrane
  • Post Translation Modifications
  • Glycosylation at Asn63, Tyr74, and Asn170
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyGen 4 sites, 2 O-linked glycans (1 site)
  • Function
  • The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses.
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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

Secondary Antibody

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