Human Anti-CD70 (clone 2H5) scFv-Fc Chimera (CAT#: VS-0325-FY72)
Anti-CD70 scFv-Fc is a recombinant antibody that binds to CD70, a protein found on some cancer cells. It's made by fusing a single-chain variable fragment (scFv) to the Fc region of an immunoglobulin.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Immunogen
- Recombinant human CD70
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CD70
- Species Reactivity
- Human
- Clone
- 2H5
- Applications
- Flow Cytometry, ELISA, Immunohistochemistry, Blocking
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 1 μg/mL
Target
- Alternative Names
- CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L; TNFRSF27
- Gene ID
- 970
- UniProt ID
- P32970
- Long Name
- CD70 Molecule
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn63, Tyr74, and Asn170
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 2 O-linked glycans (1 site)
- Protein Refseq
- XP_054178722.1; XP_054178723.1; NP_001243.1; NP_001317261.1
- Function
- The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1584z | Mouse Anti-CD70 Recombinant Antibody (clone 24B8) | FC, IF, IHC, IP | Mouse IgG1, κ |
| HPAB-0468-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0468-WJ) | ELISA | Human IgG |
| HPAB-0469-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0469-WJ) | ELISA | Human IgG |
| HPAB-0470-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0470-WJ) | ELISA | Human IgG |
| HPAB-0471-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0471-WJ) | ELISA | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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