Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced (CAT#: VS-0924-YC123)
The product is a human anti-CD70 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human and monkey CD70 and contains mutations that enhance hexamerization. These mutations promote optimal C1q binding and increase CDC effectiveness.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Host Species
- Human
- Type
- Antibody hexamer
- Specificity
- Human and Monkey CD70
- Species Reactivity
- Human, Monkey
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, Inhib, ADCC, ADCP, CDC
- Conjugate
- None
- Related Disease
- Renal carcinoma
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD27L; CD27-L; CD27LG; TNFSF7; TNLG8A
- Gene ID
- 970
- UniProt ID
- P32970
- Long Name
- CD70 Molecule
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- N-glycosylated. ( P32970-CD70_HUMAN )
Glycosylation at Asn63, Tyr74, and Asn170 ( NX_P32970 [NX_P32970-1] )
- Function
- Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, 28011864, 8387892).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, 28011864). CD70_HUMAN,P32970
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-335LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-335LC-S(P)) | ELISA | Humanized scFv |
| TAB-342LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-342LC-S(P)) | FC | Humanized scFv |
| TAB-343LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-343LC-S(P)) | FC | Humanized scFv |
| TAB-344LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-344LC-S(P)) | FC | Human scFv |
| TAB-335LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-335LC-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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