Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced (CAT#: VS-0924-YC123)
The product is a human anti-CD70 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human and monkey CD70 and contains mutations that enhance hexamerization. These mutations promote optimal C1q binding and increase CDC effectiveness.
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Subcellular Location and Protein Expression
RNA Expression

Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg

Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg

Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Host Species
- Human
- Type
- Antibody hexamer
- Specificity
- Human and Monkey CD70
- Species Reactivity
- Human, Monkey
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, Inhib, ADCC, ADCP, CDC
- Conjugate
- None
- Related Disease
- Renal carcinoma
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD27L; CD27-L; CD27LG; TNFSF7; TNLG8A
- Gene ID
- 970
- UniProt ID
- P32970
- Long Name
- CD70 Molecule
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- N-glycosylated. ( P32970-CD70_HUMAN )
Glycosylation at Asn63, Tyr74, and Asn170 ( NX_P32970 [NX_P32970-1] )
- Function
- Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, 28011864, 8387892).
The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, 28011864). CD70_HUMAN,P32970
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IgG Antibodies
Humanized Antibodies
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Blocking Antibodies
ScFv Antibodies
Fab Antibodies
ADCC Enhanced Antibodies
Hexamer Antibodies
FC Reagents & Kits
ScFv-Fc Chimeras
Extracellular Vesicle Antibodies
IHC Kits & Antibodies
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1584z | Mouse Anti-CD70 Recombinant Antibody (clone 24B8) | FC, IF, IHC, IP | Mouse IgG1, κ |
HPAB-AP584-YC | Mouse Anti-CD70 Recombinant Antibody (clone m1F6) | FC, ADCC, CDC, FuncS | Mouse IgG |
HPAB-AP585-YC | Human Anti-CD70 Recombinant Antibody (clone c1F6) | FC, ADCC, CDC, FuncS | Chimeric (mouse/human) IgG |
HPAB-AP586-YC | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA) | FC, ADCC, CDC, FuncS | Humanized (mouse/human) IgG |
HPAB-AP587-YC | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA) | FC, ADCC, CDC, FuncS | Humanized (mouse/human) IgG |
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