Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced (CAT#: VS-0924-YC123)

• Host Species
• Human

• Type
• Antibody hexamer

• Specificity
• Human and Monkey CD70

• Species Reactivity
• Human, Monkey

• Molecule Class
• ~ 900 kDa

• Applications
• ELISA, Inhib, ADCC, ADCP, CDC

• Conjugate
• None

• Related Disease
• Renal carcinoma

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• CD27L; CD27-L; CD27LG; TNFSF7; TNLG8A

• Gene ID
• 970

• UniProt ID
• P32970

• Long Name
• CD70 Molecule

• Sequence Similarities
• Belongs to the tumor necrosis factor family.

• Cellular Localization
• Cell membrane; Single-pass type II membrane protein

• Post Translation Modifications
• N-glycosylated. ( P32970-CD70_HUMAN )
  Glycosylation at Asn63, Tyr74, and Asn170 ( NX_P32970 [NX_P32970-1] )

• Function
• Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, 28011864, 8387892).
  The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, 28011864). CD70_HUMAN,P32970

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