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CD70

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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, Neut, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, IP, FuncS
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
bac
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
bac-VC
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
Mc (maleimidocaproyl)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
mc-VC (maleimidocaproyl-valine-citrulline)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
AFP (auristatin phenylalanine phenylenediamine)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
AFP (auristatin phenylalanine phenylenediamine)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
CC-1065 (rachelmycin)
Target:
CD70
Linker:
VC (valine-citrulline)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD70
Linker:
α-glucuronide
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD70
Linker:
α-glucuronide
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD70
Linker:
β-glucuronide linker
Drug:
Camptothecin Analog
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