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CD70

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
  • Anti-CD27L-MCC-DM1 ADC (ADC-038LZY)

    • Target: CD27L
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Anti-CD27L-DM1 ADC (ADC-127LZY)

    • Target: CD27L
    • Linker: Noncleavable thioether linker
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Anti-CD70 (clone 2F2)-vc-AFP ADC (ADC-115CL)

    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine)

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