Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin)

Name: Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin)
SKU: TAB-882
Rating: 5 (1 reviews)

CAT#: TAB-882

Recombinant human monoclonal antibody expressed in CHO binding to human CD70. Vorsetuzumab mafodotin is an antibody-drug conjugate (ADC) directed to the protein CD70 designed for the treatment of cancer. It is a humanized monoclonal antibody, vorsetuzumab, conjugated with noncleavable monomethyl auristatin F (MMAF), a cytotoxic agent.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1 - kappa

Species Reactivity
Human

Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.

CAS
1165741-01-4

Generic Name
Vorsetuzumab mafodotin

MW
150 kDa

Related Disease
Non-Hodgkin's lymphoma (NHL)

Product Property

Purity
Purity >95% by SDS-PAGE.

Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

Alternative Names
Vorsetuzumab mafodotin;1165741-01-4;SGN-75;h1F6-mcMMAF(4);SGN-75;CD70;CD70 molecule;CD27LG, TNFSF7, tumor necrosis factor (ligand) superfamily, member 7;CD70 antigen;CD27L;CD27-L;CD27 ligand;Ki-24 antigen;surface antigen CD70;tumor necrosis factor ligand

Gene ID
970

UniProt ID
P32970

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Biosimilar Overview

Please refer to Vorsetuzumab Mafodotin Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Vorsetuzumab Mafodotin.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-882.pdf

MSDS

MSDS - TAB-882.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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TAB-342LC-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-342LC-F(E))	FC	Humanized Fab
TAB-343LC-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-343LC-F(E))	FC	Humanized Fab
TAB-344LC-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-344LC-F(E))	FC	Humanized Fab

CAT	Product Name	Application	Type
TAB-336LC-F(E)	Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VLVH)	FC, ELISA	Human antibody
TAB-337LC-F(E)	Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VHVL)	FC, ELISA	Human antibody
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TAB-339LC-F(E)	Anti-Human CD70 Recombinant Antibody Fab Fragment (VH-5-VL)	FC, ELISA	Human antibody
TAB-340LC-F(E)	Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-8-VH)	FC, ELISA	Human antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
NEUT-404CQ	Rat Anti-Cd70 Recombinant Antibody (clone MAB0825)	Block, FC, Inhib, IP	Rat IgG2

CAT	Product Name	Application	Type
HPAB-0095-LSX	Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX)	ELISA, FC, ADCC, FuncS	Human IgG
HPAB-0096-LSX	Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX)	ELISA, FC, Block, FuncS	Human IgG
HPAB-0097-LSX	Human Anti-CD70 Recombinant Antibody (HPAB-0097-LSX)	ELISA, FC, Block, FuncS	Human IgG
HPAB-0099-LSX	Human Anti-CD70 Recombinant Antibody (HPAB-0099-LSX)	ELISA, FC, Block	Human IgG
HPAB-0100-LSX	Human Anti-CD70 Recombinant Antibody (HPAB-0100-LSX)	ELISA, Inhib, ADCC, ADCP, CDC, FuncS	Human IgG

CAT	Product Name	Application	Type
HPAB-0095-LSX-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0095-LSX-F(E))	ELISA, FC	Human Fab
HPAB-0096-LSX-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0096-LSX-F(E))	ELISA, FC	Human Fab
HPAB-0097-LSX-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0097-LSX-F(E))	ELISA, FC	Human Fab
HPAB-0098-LSX-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0098-LSX-F(E))	ELISA, FC	Human Fab
HPAB-0099-LSX-F(E)	Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0099-LSX-F(E))	ELISA, FC	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-H76	Afuco™ Anti-CD70 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H76)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-AP584-YC-S(P)	Mouse Anti-CD70 Recombinant Antibody (clone m1F6); scFv Fragment	FC, ADCC, CDC, FuncS	Mouse scFv
HPAB-AP585-YC-S(P)	Mouse Anti-CD70 Recombinant Antibody (clone c1F6); scFv Fragment	FC, ADCC, CDC, FuncS	Mouse scFv
HPAB-AP586-YC-S(P)	Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); scFv Fragment	FC, ADCC, CDC, FuncS	Humanized (mouse/human) scFv
HPAB-AP587-YC-S(P)	Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); scFv Fragment	FC, ADCC, CDC, FuncS	Humanized (mouse/human) scFv
HPAB-AP588-YC-S(P)	Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); scFv Fragment	FC, ADCC, CDC, FuncS	Humanized (mouse/human) scFv

CAT	Product Name	Application	Type
VS-0924-YC123	Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced	ELISA, Inhib, ADCC, ADCP, CDC	Antibody hexamer
VS-0924-YC124	Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced	FC, ADCC, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-0225-XY69	CytoStream™ Rat Anti-CD70 Recombinant Antibody (clone FR70)	FC, Block, IF, Inhib	Rat IgG2b, kappa
VS-0225-XY70	CytoStream™ Mouse Anti-CD70 Recombinant Antibody (clone Ki-24)	FC	Mouse IgG3, kappa

CAT	Product Name	Application	Type
VS-0325-FY72	Human Anti-CD70 (clone 2H5) scFv-Fc Chimera	FC, ELISA, IHC, Block	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC77	Recombinant Anti-CD70 Vesicular Antibody, EV Displayed (VS-0425-YC77)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1215	Anti-CD70 Immunohistochemistry Kit	IHC

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