Does this antibody bind to mouse CD70?

Yes, this Rat monoclonal antibody (clone FR70) specifically binds to Mouse Cd70. It is capable of neutralizing the bioactivity of mouse CD70.

What are the validated applications for this antibody?

This antibody is validated for multiple applications, including Flow Cytometry (FC), Functional Studies (FuncS), Neutralization (Neut), and Immunoprecipitation (IP).

Rat Anti-Cd70 Recombinant Antibody (clone FR70)

CAT#: NEUT-406CQ

This antibody is a rat monoclonal antibody that binds specifically to mouse CD70, and it can neutralize the bioactivity of mouse CD70.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70

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Specifications

Host Species
Rat

Type
Rat IgG2b, κ

Specificity
Mouse Cd70

Species Reactivity
Mouse

Clone
FR70

Applications
FC, FuncS, Neut, IP

Conjugate
Unconjugated

Product Property

Purification
Purified with affinity chromatography

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Cd70; CD70 antigen; Cd27l; CD27LG; Tnfsf7; Tnlg8a

Gene ID
21948

UniProt ID
O55237

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Breast cancer biomarkers at key points during disease progression

Validated for Neutralization

We needed an antibody to neutralize mouse Cd70 bioactivity in vitro, and clone FR70 worked perfectly. It inhibited the T-cell costimulation effectively. This rat monoclonal antibody is highly specific and has been a key reagent for our immunology studies.

Versatile Functional Antibody

Besides neutralization, we used this antibody for Flow Cytometry and Immunoprecipitation. It performed well in all applications. The affinity purification ensures a clean product. It is an essential tool for investigating the role of CD70 in T-cell activation.

Q&As

Does this antibody bind to mouse CD70?

A: Yes, this Rat monoclonal antibody (clone FR70) specifically binds to Mouse Cd70. It is capable of neutralizing the bioactivity of mouse CD70.
What are the validated applications for this antibody?

A: This antibody is validated for multiple applications, including Flow Cytometry (FC), Functional Studies (FuncS), Neutralization (Neut), and Immunoprecipitation (IP).

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - NEUT-406CQ.pdf

MSDS

MSDS - NEUT-406CQ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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