Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) (CAT#: TAB-H76)
Recombinant Humanized (from mouse) antibody to Human CD70. Vorsetuzumab is a monoclonal antibody designed for the treatment of cancer.
Specific Inquiry
Figure 1 Treatment with vorsetuzumab and KWAR23 led to strong inhibition of tumor growth in SRG mice.
Tumor growth in SRG mice treated with PBS (n = 7), vorsetuzumab (n = 3), vorsetuzumab + KWAR23 (n = 5), or bispecific anti-CD70/KWAR23 (n = 6). The color of the stars indicates comparison of the PBS group with the corresponding treatment group. ns, not significant.
Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J. P., George, B. M., ... & Zheng, Y. (2017). Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences, 114(49), E10578-E10585.
Figure 2 In vitro experiments show that KWAR23 only moderately induced macrophage phagocytosis of four different renal carcinoma cell lines (RCC4, RCC10, TK10, and Caki-1) following incubation with the anti-human CD70 antibody vorsetuzumab.
Phagocytosis of four different renal carcinoma cells by human macrophages following treatment with vorsetuzumab, vorsetuzumab + KWAR23, bispecific anti-human CD70/KWAR23, and anti-human CD47 antibody (n = 4). Mean ± SEM is shown. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (unpaired two-tailed Student's t test).
Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J. P., George, B. M., ... & Zheng, Y. (2017). Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences, 114(49), E10578-E10585.
Specifications
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- CD70 (tumor necrosis factor superfamily member 7, TNFSF7, CD27LG, CD27L) [Homo sapiens]
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC
- CAS
- 1165740-62-4
- Generic Name
- vorsetuzumab
- MW
- 146.1 kDa
- Related Disease
- Autoimmune diseases
Product Property
- Purity
- Purity >95% by SDS-PAGE.
Applications
- Application Notes
- The CD70 antibody has been reported in applications of Inhib, In vitro experiments.
Target
- Alternative Names
- vorsetuzumab;1165740-62-4;SGN-70;h1F6;CD70;CD70 molecule;CD27LG, TNFSF7, tumor necrosis factor (ligand) superfamily, member 7;CD70 antigen;CD27L;CD27-L;CD27 ligand;Ki-24 antigen;surface antigen CD70;tumor necrosis factor ligand superfamily member 7;tumor
- Gene ID
- 970
- UniProt ID
- P32970
Related Resources
Please refer to Vorsetuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Vorsetuzumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Vorsetuzumab"
Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human CD70. Vorsetuzumab is a monoclonal antibody designed for the treatment of cancer.
See other products for "CD70"
Select a product category from the dropdown menu below to view related products.
Please select product type
Humanized Antibody
Human Antibody
Neutralizing Antibody
Blocking Antibody
Recombinant Antibody
scFv Fragment Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
| TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
| TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
| TAB-344LC | Human Anti-CD70 Recombinant Antibody (TAB-344LC) | FC, FuncS | Humanized antibody |
| TAB-335LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-335LC-S(P)) | ELISA | Humanized scFv |
Customer Reviews and Q&As
Customer Review
Q&As
-
Excellent for CD70 Studies
The Anti-Human CD70 Therapeutic Antibody (vorsetuzumab) has been excellent for our CD70 detection assays. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time. -
Reliable in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for CD70 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab. -
Consistent High-Quality Results
This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for CD70 have been particularly beneficial.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-H76, RRID: AB_3112047)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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