This product is a recombinant human antibody that recognizes DLL4. Mab YW26.82 selectively binds to mouse and human DLL4. It recognized a binding determinant present in EGF-like repeat number 2 (EGL2) of the human DLL4 extracellular domain (ECD). EGL2 comprises amino acids 252-282 of the human DLL4 ECD.
Figure 1 DLL4-mediated Notch signaling regulated EC pro liferation.
Anti-DLL4 antibody (YW26.82) or DBZ promoted the sprouting of HUVECs
Figure 2 Characterization of anti-DLL4 antibody.
The binding of YW26.82 at indicated concentrations was measured by ELISA assay. Bound antibodies were detected with anti-human antibody HRP conjugate using TMB as substrate and OD 450 nm absorbance measurement. Anti-HER2 and recombinant ErbB2-ECD were used as assay control.
Figure 3 FACS analysis of 293 cells transiently transfected with vector, full length DLL4, Jag1 or DLL1. Significant binding of YW26.82 was only detected on DLL4 transfected cells.
Expression of Jag1 and DLL1 was con firmed by the binding of recombinant rat Notch1-Fc and recombinant rat Notch2-Fc, respectively. YW26.82. rrNotch1-Fc or rrNotch2-Fc were used at 2 ug/ml followed by goat anti-human IgG-PE.
Figure 4 Anti-DLL4 antibody blocked the binding of DLL4-AP, but not DLL1-AP, to coated rNotch1.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-204 | Anti-Human DLL4 Recombinant Antibody (Demcizumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG2 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-217CL | Human Anti-DLL4 Recombinant Antibody (TAB-217CL) | WB, IHC, IF, FC, Inhib | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-217MZ | Human Anti-DLL4 Recombinant Antibody (TAB-217MZ) | FC, FuncS | Chimeric (mouse/human) IgG |
TAB-217MZ-S(P) | Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-217MZ-S(P)) | FC | Mouse scFv |
TAB-217MZ-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-217MZ-F(E)) | FC | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-226MZ-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-226MZ-S(P)) | FC | Human scFv |
TAB-228MZ-S(P) | Anti-Human DLL4 Recombinant Antibody scFv Fragment (12.73) | ELISA, FC | Human antibody |
TAB-229MZ-S(P) | Anti-Human DLL4 Recombinant Antibody scFv Fragment (12.08) | ELISA, FC | Human antibody |
TAB-230MZ-S(P) | Anti-Human DLL4 Recombinant Antibody scFv Fragment (12.14) | ELISA, FC | Human antibody |
TAB-231MZ-S(P) | Anti-Human DLL4 Recombinant Antibody scFv Fragment (12.55) | ELISA, FC | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-227MZ-F(E) | Anti-Human DLL4 Recombinant Antibody Fab Fragment (1C1) | ELISA, FC | |
TAB-232MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-232MZ-F(E)) | ELISA, FC | Rat Fab |
TAB-233MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-233MZ-F(E)) | ELISA, FC | Rat Fab |
TAB-234MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-234MZ-F(E)) | ELISA, FC | Rat Fab |
TAB-235MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-235MZ-F(E)) | ELISA, FC | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-707CQ | Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2) | Block | Hamster IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4140 | Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0207-CN | Human Anti-DLL4 Recombinant Antibody (HPAB-0207-CN) | ELISA, WB, FC, IHC, IF, ICC | Chimeric (mouse/human) IgG1, κ |
HPAB-0142-FY | Human Anti-DLL4 Recombinant Antibody (clone 12.3 1 C1) | ELISA | Human IgG |
FN-220CQ | Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-1) | FC, FuncS, IF | Hamster IgG |
VS3-XY583 | Mouse Anti-DLL4 Recombinant Antibody (clone 4A11F8) | ELISA, WB, IHC | Mouse IgG1 |
VS3-XY584 | Mouse Anti-DLL4 Recombinant Antibody (clone 4A11) | ELISA, WB, FC | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0075-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0075-CN-S(P)) | ELISA, WB, FC | Human scFv |
HPAB-0076-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0076-CN-S(P)) | ELISA, WB, FC | Human scFv |
HPAB-0203-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0203-CN-S(P)) | ELISA, WB, FC, IP | Human scFv |
HPAB-0204-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0204-CN-S(P)) | ELISA, WB, FC, IP | Human scFv |
HPAB-0716-FY-F(E) | Mouse Anti-DLL4 Recombinant Antibody (clone AB015); scFv Fragment | FC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0203-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0203-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
HPAB-0204-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0204-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
HPAB-0205-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0205-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
HPAB-0206-CN-F(E) | Mouse Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0206-CN-F(E)) | ELISA, WB, FC, IHC, IF, ICC | Mouse Fab |
HPAB-0208-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0208-CN-F(E)) | ELISA, WB, FC, IHC, IF, ICC | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-204 | Afuco™ Anti-DLL4 ADCC Recombinant Antibody (Demcizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1512-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (56A09) | Block, ELISA, FC | Llama VHH |
HPAB-1513-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (56H08) | Block, ELISA, FC | Llama VHH |
HPAB-1514-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (104G01) | Block, ELISA, FC | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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