AbPlus™ Anti-ERBB3 Magnetic Beads (Duligotuzumab)
CAT#: VS-0424-XY92
The AbPlus Anti-ERBB3 Magnetic Beads (Duligotuzumab) is an innovative affinity resin which is bound with anti-ERBB3 specific antibody (Duligotuzumab). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of ERBB3 protein under native and denaturing conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70524/162441_A_4_2_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in renal tubular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_8_5_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/659_B11_4_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 6 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/658_B11_1_blue_red_green.jpg
Normal Tissue
Figure 7 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_7_5.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_9_3.jpg
Normal Tissue
Figure 9 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_8_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_5.jpg
Normal Tissue
Figure 11 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_4_6.jpg
Normal Tissue
Figure 12 Skin
Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Langerhans
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Melanocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_8_1.jpg
Normal Tissue
Figure 13 Lymph node
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_8.jpg
RNA Expression
Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000065361-ERBB3
❮
❯
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-ERBB3 specific antibody (Duligotuzumab)
- Target
- ERBB3
- Target Species
- Human
- Antibody Clone
- Duligotuzumab
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
- Alternative Names
- Duligotuzumab;1314238-96-4;RG7597;Anti-HER3/EGFR DAF;MEHD7945A;MEHD;ERBB3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian);LCCS2, lethal congenital contracture syndrome 2;receptor tyrosine-protein kinase erbB-3;HER3;proto-oncogene-like prot
- Gene ID
- 2065
- UniProt ID
- P21860
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379); scFv Fragment | ELISA, WB, IF, FuncS | Human scFv |
| PSBL-127 | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBL-127) | ELISA, WB, FuncS | Human scFv |
| PSBL-128 | Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBL-128) | WB, Block, FuncS | Mouse scFv |
| HPAB-0724-FY-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone AB062); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0783-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody (clone Hu-Lc9); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0033CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0033CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0034CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0034CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0035CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0035CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0036CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0036CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0037CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0037CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0508CL-S(P) | Anti-Human ERBB3 Recombinant Antibody scFv Fragment (1A5) | ELISA, Inhib, FuncS | |
| TAB-0509CL-S(P) | Anti-Human ERBB3 Recombinant Antibody scFv Fragment (3D4) | ELISA, Inhib, FuncS | |
| TAB-0508CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (1A5) | ELISA, Inhib, FuncS | |
| TAB-0509CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (3D4) | ELISA, Inhib, FuncS | |
| TAB-067CT-S(P) | Anti-Human HER3 Recombinant Antibody scFv Fragment (5101) | ELISA, Inhibition, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-057CT | Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) | Inhibion, ELISA | Humanized antibody |
| TAB-057CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-057CT-S(P)) | Inhibion, ELISA | Humanized scFv |
| TAB-058CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-058CT-S(P)) | WB, ELISA, Inhib | Human scFv |
| TAB-059CT-S(P) | Anti-Human HER3 Recombinant Antibody scFv Fragment (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
| TAB-063CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-063CT-S(P)) | ELISA, Inhib, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
| TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
| TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
| NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
| NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
| NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (NEUT-742CQ) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0081-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0081-FY) | Inhib, FuncS | Humanized IgG1, κ |
| HPAB-0120-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0120-FY) | ELISA, WB | Humanized IgG1, κ |
| HPAB-0128-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0128-FY) | ELISA | Humanized IgG1, κ |
| HPAB-0181-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0181-FY) | ELISA, FC | Human IgG1 |
| HPAB-0182-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0182-FY) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H21) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-422CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
| AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H22) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-892) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0171-WJ-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0171-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0200-WJ-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 205.10.1); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0274-YJ-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0274-YJ-F(E)) | ELISA, FC, Inhib, FuncS | Human Fab |
| HPAB-0275-YJ-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0275-YJ-F(E)) | ELISA, FC, IHC, Inhib, IP, WB, FuncS | Mouse Fab |
| HPAB-0276-YJ-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0276-YJ-F(E)) | ELISA, FC, IHC, Inhib, IP, WB, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1400 | AbPlus™ Anti-ERBB3 Magnetic Beads (VS-0724-YC1400) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY22 | Human Anti-ERBB3 (clone H3) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| VS-0125-FY23 | Human Anti-ERBB3 (clone PM6) scFv-Fc Chimera | WB, ELISA, IHC, FuncS, BI | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC478 | Recombinant Anti-ERBB3 Vesicular Antibody, EV Displayed (VS-0425-YC478) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2337 | Anti-ERBB3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2338 | Anti-Mouse ERBB3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC72 | Recombinant Anti-ERBB3 (Domain 1 x Domain 3) Biparatopic Antibody, Tandem scFv (Clone 1153 x Clone 920104) | ELISA, FC | Tandem scFv |
| VS-0525-YC74 | Recombinant Anti-ERBB3 (Domain 3 x Domain 4) Biparatopic Antibody, Tandem scFv (Clone 920104 x Clone 1126) | ELISA, FC | Tandem scFv |
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