Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-892)
CAT#: AFC-TAB-892
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human ERBB3.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70524/162441_A_4_2_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in renal tubular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_8_5_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/659_B11_4_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 6 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/658_B11_1_blue_red_green.jpg
Normal Tissue
Figure 7 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_7_5.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_9_3.jpg
Normal Tissue
Figure 9 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_8_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_5.jpg
Normal Tissue
Figure 11 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_4_6.jpg
Normal Tissue
Figure 12 Skin
Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Langerhans
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Melanocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_8_1.jpg
Normal Tissue
Figure 13 Lymph node
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_8.jpg
RNA Expression
Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000065361-ERBB3
❮
❯
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Generic Name
- Seribantumab
- Related Disease
- Breast cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
REVIEWS AND Q&AS
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Seribantumab"
Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab)Recombinant humanized antibody expressed in CHO binding to human ERBB3. Seribantumab is used to treat cancer.
DrugMonitor™ Anti-Seribantumab Antibody (VS-1224-YC1075)Seribantumab is a fully human monoclonal antibody targeting Her3 with potential antineoplastic activity, used in trials for NSCLC, colorectal cancer, and other solid tumors. The DrugMonitor™ Anti-Seribantumab Antibody (VS-1224-YC1075) is an anti-drug antibody (ADA) against Seribantumab. This drug-based antibody is raised in mice immunized with the Seribantumab. The anti-Seribantumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Seribantumab in samples.
See other products for "ERBB3"
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379) | ELISA, WB, IF, FuncS | Human IgG |
| PABL-127 | Human Anti-ERBB3 Recombinant Antibody (PABL-127) | ELISA, WB, FuncS | Human IgG |
| PABL-128 | Mouse Anti-ERBB3 Recombinant Antibody (PABL-128) | WB, Block, FuncS | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0033CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0033CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0034CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0034CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0035CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0035CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0036CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0036CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0037CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0037CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0508CL | Anti-Human ERBB3 Recombinant Antibody (1A5) | ELISA, FC, Inhib, FuncS | |
| TAB-0509CL | Anti-Human ERBB3 Recombinant Antibody (3D4) | Inhib, FC | |
| TAB-0552CL-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0552CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-0553CL-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0553CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-067CT-S(P) | Anti-Human HER3 Recombinant Antibody scFv Fragment (5101) | ELISA, Inhibition, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-057CT | Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) | Inhibion, ELISA | Humanized antibody |
| TAB-058CT | Human Anti-ERBB3 Recombinant Antibody (TAB-058CT) | ELISA, Inhib, Cty, IHC, WB, FC | Human IgG1, κ |
| TAB-059CT | Anti-Human HER3 Recombinant Antibody (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
| TAB-063CT | Human Anti-ERBB3 Recombinant Antibody (TAB-063CT) | IF, WB, Inhib, ELISA | Humanized antibody |
| TAB-057CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-057CT-F(E)) | Inhibion, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
| TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
| TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
| NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
| NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
| NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (NEUT-742CQ) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0022-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0024-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0024-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0025-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0025-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0171-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0171-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0200-WJ-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 205.10.1); scFv Fragment | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-685-FY-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-685-FY-F(E)) | WB, Inhib | Mouse Fab |
| HPAB-686-FY-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-686-FY-F(E)) | WB, Inhib | Mouse Fab |
| HPAB-0724-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone AB062); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0783-FY-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone Hu-Lc9); Fab Fragment | ELISA | Human Fab |
| HPAB-0784-FY-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone Hu-2Hl); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H21) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-422CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
| AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H22) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY92 | AbPlus™ Anti-ERBB3 Magnetic Beads (Duligotuzumab) | IP, Protein Purification | |
| VS-0724-YC1400 | AbPlus™ Anti-ERBB3 Magnetic Beads (VS-0724-YC1400) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY22 | Human Anti-ERBB3 (clone H3) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| VS-0125-FY23 | Human Anti-ERBB3 (clone PM6) scFv-Fc Chimera | WB, ELISA, IHC, FuncS, BI | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC478 | Recombinant Anti-ERBB3 Vesicular Antibody, EV Displayed (VS-0425-YC478) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2337 | Anti-ERBB3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2338 | Anti-Mouse ERBB3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC72 | Recombinant Anti-ERBB3 (Domain 1 x Domain 3) Biparatopic Antibody, Tandem scFv (Clone 1153 x Clone 920104) | ELISA, FC | Tandem scFv |
| VS-0525-YC74 | Recombinant Anti-ERBB3 (Domain 3 x Domain 4) Biparatopic Antibody, Tandem scFv (Clone 920104 x Clone 1126) | ELISA, FC | Tandem scFv |
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