Human Anti-ERBB3 (clone PM6) scFv-Fc Chimera (CAT#: VS-0125-FY23)

Anti-HER3 scFv-Fc is a recombinant antibody targeting the HER3 receptor, whose unique structure plays a significant role in biomedical research, particularly in the field of cancer research. HER3 is a member of the human epidermal growth factor receptor family and is often highly expressed in certain cancer cells, such as the FaDu cell line. Therefore, anti-HER3 scFv-Fc can specifically bind to the HER3 receptor, targeting these cancer cells and providing a more effective targeted therapy. Moreover, the application of this antibody is not limited to cancer-targeted therapy; it can also be extended to tumor imaging, assisting researchers in better tracking tumor growth and metastasis, ultimately supporting clinical treatment.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Species Reactivity
  • Human
  • Clone
  • PM6
  • Applications
  • Western Blot, ELISA, Immunohistochemistry, Functional Assay, Bioimaging
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Stabilizer
  • No Stabilizers
  • Sterility
  • 0.2 μM filtered
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • By combining with the HER3 antigen, scFv-Fc can be used for cancer imaging (such as labeling with IRDye800CW) and potential targeted therapy. It can accumulate in HER3-positive cells and tumor tissues, making it useful for monitoring dynamic changes in tumors.

Target

  • Alternative Names
  • Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; Receptor Tyrosine-Protein Kinase ErbB-3; P180-ErbB3
  • Cellular Localization
  • Cell membrane
  • Post Translation Modifications
  • Glycosylation at Asn126, Asn250, Asn353, Asn408, Asn414, Asn437, Asn469, Asn522, Asn566, and Asn616
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect ERBB3_HUMAN (1711)
    Glycosylation from GlyGen 10 sites, 5 N-linked glycans (3 sites)
  • Function
  • Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins.
    Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
    May also be activated by CSPG5.
    Involved in the regulation of myeloid cell differentiation.

Recommended Products

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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