What is this recombinant antibody designed to target?

Her3, a member of the ErbB protein family, is the specific target of the anti-Her3 antibody.

What kind of diseases can the Anti-Human ERBB3 Recombinant Antibody (1A5) be used in?

The particular antibody has the potential to cure proliferative illnesses such as breast and gastric cancer by binding to the Her3.

What species is this antibody derived from?

Mice are the source of the Anti-Human ERBB3 Recombinant Antibody (1A5).

Anti-Human ERBB3 Recombinant Antibody (1A5)

CAT#: TAB-0508CL

The anti-Her3 antibody specifically target Her3 which is a member of the ErbB protein family. By binding to the Her3, the specific antibody can be used in the treatment of proliferative disorders like cancer.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/if_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human testis

Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70524/162441_A_4_2_selected.jpg

Subcellular Location and Protein Expression Figure 4 IHC staining of human kidney

Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in renal tubular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_8_5_selected.jpg

Subcellular Location and Protein Expression Figure 5 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/659_B11_4_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 6 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/658_B11_1_blue_red_green.jpg

Normal Tissue Figure 7 Cerebral cortex

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_7_5.jpg

Normal Tissue Figure 8 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_9_3.jpg

Normal Tissue Figure 9 Liver

Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_8_4.jpg

Normal Tissue Figure 10 Kidney

Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_5.jpg

Normal Tissue Figure 11 Testis

Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_4_6.jpg

Normal Tissue Figure 12 Skin

Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Langerhans
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Melanocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_8_1.jpg

Normal Tissue Figure 13 Lymph node

Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_8.jpg

RNA Expression Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000065361-ERBB3

❮

❯

Specifications

Host Species
Mouse

Specificity
Human

Clone
1A5

Related Disease
Gastric cancerc, breast cancer

Target

Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Gene ID
2065

UniProt ID
P21860

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Breast cancer biomarkers at key points during disease progression

Excellent Technical Assistance

The technical assistancet team provided comprehensive and prompt responses to all queries. Their assistance has been invaluable in ensuring our experiments run smoothly.

Good stability over time

Stored the antibody at -20°C for several months, and it retained excellent binding capabilities. Great for long-term projects.

Efficient for multiplex assays

Used this antibody alongside others in a multiplex assay. There were no cross-reactivity issues, and the detection was precise and accurate.

Q&As

What is this recombinant antibody designed to target?

A: Her3, a member of the ErbB protein family, is the specific target of the anti-Her3 antibody.
What kind of diseases can the Anti-Human ERBB3 Recombinant Antibody (1A5) be used in?

A: The particular antibody has the potential to cure proliferative illnesses such as breast and gastric cancer by binding to the Her3.
What species is this antibody derived from?

A: Mice are the source of the Anti-Human ERBB3 Recombinant Antibody (1A5).

View the frequently asked questions answered by Creative Biolabs Support.

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-0508CL.pdf

MSDS

MSDS - TAB-0508CL.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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NAB-1729-sdAb	Recombinant Anti-human ERBB3 VHH Single Domain Antibody	WB, ICC, ChiP, FA, ELISA	Llama VHH
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PABC-556	Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556)	ELISA, SPR	Llama VHH

CAT	Product Name	Application	Type
AGTO-L074E	HRGβ2-PE immunotoxin	Cytotoxicity assay, Functional assay

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TAB-0033CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0033CL)	ELISA, FuncS, Inhib, FC	Human IgG
TAB-0034CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0034CL)	ELISA, FuncS, Inhib, FC	Human IgG
TAB-0035CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0035CL)	ELISA, FuncS, Inhib, FC	Human IgG
TAB-0036CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0036CL)	ELISA, FuncS, Inhib, FC	Human IgG
TAB-0037CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0037CL)	ELISA, FuncS, Inhib, FC	Human IgG

CAT	Product Name	Application	Type
TAB-0508CL-F(E)	Anti-Human ERBB3 Recombinant Antibody Fab Fragment (1A5)	ELISA, Inhib, FuncS
TAB-0552CL-F(E)	Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0552CL-F(E))	ELISA, Inhib	Mouse Fab
TAB-0553CL-F(E)	Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0553CL-F(E))	ELISA, Inhib	Mouse Fab
TAB-060CT-S(P)	Rabbit Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-060CT-S(P))	Inhib, ELISA	Rabbit scFv
TAB-064CT-S(P)	Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-064CT-S(P))	ELISA, FC	Mouse scFv

CAT	Product Name	Application	Type
TAB-057CT	Human Anti-ERBB3 Recombinant Antibody (TAB-057CT)	Inhibion, ELISA	Humanized antibody
TAB-058CT	Human Anti-ERBB3 Recombinant Antibody (TAB-058CT)	ELISA, Inhib, Cty, IHC, WB, FC	Human IgG1, κ
TAB-059CT	Anti-Human HER3 Recombinant Antibody (LMAb3)	WB, ELISA, Inhibition, FC	Humanized antibody
TAB-063CT	Human Anti-ERBB3 Recombinant Antibody (TAB-063CT)	IF, WB, Inhib, ELISA	Humanized antibody
TAB-063CT-F(E)	Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-063CT-F(E))	ELISA, Inhib, FC	Humanized Fab

CAT	Product Name	Application	Type
TAB-061CT	Human Anti-ERBB3 Recombinant Antibody (TAB-061CT)	Inhib, ELISA	Chimeric (Rabbit/Human) antibody
TAB-061CT-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P))	Inhib, ELISA	Human scFv
TAB-061CT-F(E)	Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E))	Inhib, ELISA	Chimeric (Rabbit/Human) Fab

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NEUT-738CQ	Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932)	Neut, IP	Mouse IgG1
NEUT-739CQ	Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483)	FC, CyTOF®, ELISA, Neut	Mouse IgG1
NEUT-740CQ	Human Anti-ERBB3 Recombinant Antibody (clone CBL1019)	Neut	Human IgG1, κ
NEUT-741CQ	Human Anti-ERBB3 Recombinant Antibody (clone CBL1020)	Neut	Human IgG1, κ
NEUT-742CQ	Mouse Anti-ERBB3 Recombinant Antibody (NEUT-742CQ)	Neut	Mouse IgG1

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MOR-1179	Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB)	ICC, IF, WB	Rabbit IgG

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HPAB-0286-YC-S(P)	Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); scFv Fragment	ELISA, FuncS, FC	Mouse scFv
HPAB-0287-YC-S(P)	Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); scFv Fragment	ELISA, FuncS, FC	Mouse scFv
HPAB-0288-YC-S(P)	Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); scFv Fragment	ELISA, FuncS, FC	Mouse scFv
HPAB-0289-YC-S(P)	Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); scFv Fragment	ELISA, FuncS, FC	Mouse scFv
HPAB-0290-YC-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0290-YC-S(P))	ELISA, FuncS, FC	Human scFv

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AFC-TAB-H21	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H21)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-422CQ	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-422CQ)	ELISA, IHC, FC, IP, IF, BL	ADCC enhanced antibody
AFC-TAB-189	Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced	IP, IF, FuncS, FC, Neut, ELISA	Human IgG1, κ
AFC-TAB-H22	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H22)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-892	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-892)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-2323LY-F(E)	Human Anti-ERBB3 Recombinant Antibody (clone A); Fab Fragment	ELISA, RIA	Human Fab
HPAB-0724-FY-S(P)	Mouse Anti-ERBB3 Recombinant Antibody (clone AB062); Fab Fragment	ELISA	Mouse Fab
HPAB-0783-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody (clone Hu-Lc9); Fab Fragment	ELISA	Human Fab
HPAB-0784-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody (clone Hu-2Hl); Fab Fragment	ELISA	Human Fab
HPAB-0806-FY-S(P)	Mouse Anti-ERBB3 Recombinant Antibody scFv Fragment (HPAB-0806-FY-S(P))	Inhib	Mouse scFv

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HPAB-M0309-YC	Mouse Anti-ERBB3 Recombinant Antibody (HPAB-M0309-YC)	ELISA, Neut	Mouse IgG1, κ
HPAB-M0310-YC	Human Anti-ERBB3 Recombinant Antibody (HPAB-M0310-YC)	ELISA, Neut	Chimeric (mouse/human) IgG1, κ
HPAB-M0335-YC	Human Anti-ERBB3 Recombinant Antibody (HPAB-M0335-YC)	ELISA, Neut, FuncS	Humanized IgG2, κ
HPAB-M0348-YC	Mouse Anti-ERBB3 Recombinant Antibody (HPAB-M0348-YC)	ELISA, Neut	Mouse IgG2b, κ
HPAB-0756-WJ	Mouse Anti-ERBB3 Recombinant Antibody (HPAB-0756-WJ)	ELISA	Mouse IgG

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VS-0424-XY92	AbPlus™ Anti-ERBB3 Magnetic Beads (Duligotuzumab)	IP, Protein Purification
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VS-0125-FY22	Human Anti-ERBB3 (clone H3) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc
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VS-0425-YC478	Recombinant Anti-ERBB3 Vesicular Antibody, EV Displayed (VS-0425-YC478)	ELISA, FC, Neut, Cell-uptake

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VS-0525-XY2337	Anti-ERBB3 Immunohistochemistry Kit	IHC
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VS-0525-YC72	Recombinant Anti-ERBB3 (Domain 1 x Domain 3) Biparatopic Antibody, Tandem scFv (Clone 1153 x Clone 920104)	ELISA, FC	Tandem scFv
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