Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) (CAT#: PABC-556)

This product is a recombinant Llama antibody that can recognize ErbB3. BCD090-M2 recognises erbB3, a receptor tyrosine kinase.

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SPR

Figure 1 Binding of BCD090-M2 VHH antibody to the extracellular domain of human ErbB3 receptor analyzed by surface plasmon resonance.

Figure 1 Binding of BCD090-M2 VHH antibody to the extracellular domain of human ErbB3 receptor analyzed by surface plasmon resonance.

Eliseev, I. E., Yudenko, A. N., Vysochinskaya, V. V., Svirina, A. A., Evstratyeva, A. V., Drozhzhachih, M. S., ... & Ulitin, A. B. (2018). Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor. F1000Research, 7.

SPR

Figure 2 Binding of BCD090-M2 VHH antibody to the extracellular domain of human ErbB3 receptor analyzed by surface plasmon resonance.

Figure 2 Binding of BCD090-M2 VHH antibody to the extracellular domain of human ErbB3 receptor analyzed by surface plasmon resonance.

Fitting of the measured response as a function of concentration of free BCD090-M2 in solution with a simple bimolecular equilibrium binding model gives KD=1 μM.

Eliseev, I. E., Yudenko, A. N., Vysochinskaya, V. V., Svirina, A. A., Evstratyeva, A. V., Drozhzhachih, M. S., ... & Ulitin, A. B. (2018). Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor. F1000Research, 7.


Specifications

  • Host Species
  • Llama
  • Type
  • Llama VHH
  • Specificity
  • Human ErbB3
  • Species Reactivity
  • Human
  • Clone
  • PABC-556
  • Applications
  • ELISA, SPR

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Surface Plasmon Resonance and Enzyme-linked Immunosorbent Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; LCCS2

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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