Anti-Human ERBB3 Recombinant Antibody (3D4) (CAT#: TAB-0509CL)

The anti-Her3 antibody specifically target Her3 which is a member of the ErbB protein family. By binding to the Her3, the specific antibody can be used in the treatment of proliferative disorders like cancer.

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Inhib

Figure 1 Activation of NRG1-dependent HER3 abolishes inhibitory effects of trastuzumab in BT474 cells.

Figure 1 Activation of NRG1-dependent HER3 abolishes inhibitory effects of trastuzumab in BT474 cells.

p-HER3 was significantly downregulated by HER3 antibody after NRG1 stimulation.

Yang, L., Li, Y., Shen, E., Cao, F., Li, L., Li, X., ... & Li, Q. (2017). NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. International journal of oncology, 51(5), 1553-1562.

FC

Figure 2 The NRG1-dependent HER3 antibody promotes early apoptosis in BT474 cells.

Figure 2 The NRG1-dependent HER3 antibody promotes early apoptosis in BT474 cells.

Without NRG1 stimulation, trastuzumab significantly increased early apoptosis of BT474 cells when compared to the control (P<0.05).

Yang, L., Li, Y., Shen, E., Cao, F., Li, L., Li, X., ... & Li, Q. (2017). NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. International journal of oncology, 51(5), 1553-1562.

Inhib

Figure 3 HER3 antibody combined with trastuzumab synergistically inhibits cell viability.

Figure 3 HER3 antibody combined with trastuzumab synergistically inhibits cell viability.

In BT474 cells, the inhibitory effect of trastuzumab on cell viability was gradually enhanced with the increase of drug concentration. However, the effect on MDA-MB-453 cells was weak and stable. After NRG1 combined with trastuzumab, the cell viability was significantly increased in BT474 cells, however, this significant increase was not observed in MDA-MB-453 cells.

Yang, L., Li, Y., Shen, E., Cao, F., Li, L., Li, X., ... & Li, Q. (2017). NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. International journal of oncology, 51(5), 1553-1562.


Specifications

  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 3D4
  • Applications
  • Inhib, FC
  • Related Disease
  • Gastric cancerc, breast cancer

Applications

  • Application Notes
  • The Her3 antibody has been reported in applications of Inhibition, Flow Cytometry.

Target

  • Alternative Names
  • ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Single-domain Antibody

Humanized Antibody

CAT Product Name Application Type
TAB-892 Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG2 - lambda
TAB-H22 Anti-Human ERBB3 Recombinant Antibody (Duligotuzumab) (TAB-H22) ELISA, IP, FC, FuncS, Neut, IF, ICC IgG1 - kappa
TAB-057CT Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) Inhibion, ELISA Humanized antibody
TAB-058CT Human Anti-ERBB3 Recombinant Antibody (TAB-058CT) ELISA, Inhib, Cty, IHC, WB, FC Human IgG1, κ
TAB-059CT Anti-Human HER3 Recombinant Antibody (LMAb3) WB, ELISA, Inhibition, FC Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L074E HRGβ2-PE immunotoxin Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-061CT Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) Inhib, ELISA Chimeric (Rabbit/Human) antibody
TAB-061CT-S(P) Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) Inhib, ELISA Human scFv
TAB-061CT-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) Inhib, ELISA Chimeric (Rabbit/Human) Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1179 Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) ICC, IF, WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H21 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-422CQ Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, BL ADCC enhanced antibody
AFC-TAB-189 Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA Human IgG1, κ
AFC-TAB-H22 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-892 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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