Anti-Human ERBB3 Recombinant Antibody (3D4) (CAT#: TAB-0509CL)
The anti-Her3 antibody specifically target Her3 which is a member of the ErbB protein family. By binding to the Her3, the specific antibody can be used in the treatment of proliferative disorders like cancer.
Specific Inquiry
Inhib
Figure 1 Activation of NRG1-dependent HER3 abolishes inhibitory effects of trastuzumab in BT474 cells.
p-HER3 was significantly downregulated by HER3 antibody after NRG1 stimulation.
Yang, L., Li, Y., Shen, E., Cao, F., Li, L., Li, X., ... & Li, Q. (2017). NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. International journal of oncology, 51(5), 1553-1562.
FC
Figure 2 The NRG1-dependent HER3 antibody promotes early apoptosis in BT474 cells.
Without NRG1 stimulation, trastuzumab significantly increased early apoptosis of BT474 cells when compared to the control (P<0.05).
Yang, L., Li, Y., Shen, E., Cao, F., Li, L., Li, X., ... & Li, Q. (2017). NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. International journal of oncology, 51(5), 1553-1562.
Inhib
Figure 3 HER3 antibody combined with trastuzumab synergistically inhibits cell viability.
In BT474 cells, the inhibitory effect of trastuzumab on cell viability was gradually enhanced with the increase of drug concentration. However, the effect on MDA-MB-453 cells was weak and stable. After NRG1 combined with trastuzumab, the cell viability was significantly increased in BT474 cells, however, this significant increase was not observed in MDA-MB-453 cells.
Yang, L., Li, Y., Shen, E., Cao, F., Li, L., Li, X., ... & Li, Q. (2017). NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. International journal of oncology, 51(5), 1553-1562.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 3D4
- Applications
- Inhib, FC
- Related Disease
- Gastric cancerc, breast cancer
Applications
- Application Notes
- The Her3 antibody has been reported in applications of Inhibition, Flow Cytometry.
Target
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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