Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment (CAT#: HPAB-0052-YJ-S(P))

This product is a recombinant human scFv that recognizes human AILIM. The antibody AIH5D3 (JMab-136) is cross-reactive with human AILIM, Mouse AILIM, and Rat AILIM. It is capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that AIH5D3 (JMab-136) is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.


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SDS-PAGE

Figure 1 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in SDS-PAGE

Figure 1 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in SDS-PAGE

Lane 1: Non-reduced scFv
Lane 2: Reduced scFv

WB

Figure 2 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in WB

Figure 2 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in WB

Western blot analysis of HPAB-0052-YJ-S(P) was performed by loading recombinant Human ICOS with hFc-tag.

HPAB-0052-YJ-S(P) incubation concentration: 2 ng/μL.
The secondary antibody: HRP-Anti-his tag antibody
Lane 1: Reducing Antigen (0.1 μg)
Lane 2: Reducing Antigen (0.3 μg)
Lane 3: Reducing Antigen (0.6 μg)

ELISA

Figure 3 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in ELISA

Figure 3 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in ELISA

ELISA analysis of HPAB-0052-YJ-S(P) was performed by coating with recombinant Human ICOS with hFc-tag.

The secondary antibody: HRP-Anti-his tag antibody

DB

Figure 4 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in DB

Figure 4 Human Anti-ICOS Recombinant Antibody (clone JMab-136); scFv Fragment, gggc tag (HPAB-0052-YJ-S(P)) in DB

Dot Blot analysis of HPAB-0052-YJ-S(P) was performed by coating with recombinant Human ICOS with hFc-tag.

The secondary antibody: HRP-Anti-his tag antibody


Specifications

  • Immunogen
  • Cell membrane fraction prepared from recombinant cells (HPB-ALL cells or CHO cells) overexpressing human AILIM.
  • Host Species
  • Human
  • Type
  • Human scFv
  • Specificity
  • Human
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • JMab-136
  • Applications
  • ELISA
  • Related Disease
  • Disorders related to the delayed allergy

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • AILIM; CD278; CVID1; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator; inducible costimulator; AIH5D3 (JMab-136)

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone JMab-136"

See other products for "ICOS"

Neutralizing Antibody

CAT Product Name Application Type
NEUT-941CQ Mouse Anti-ICOS Recombinant Antibody (clone CBL817) Neut, FC, CyTOF Mouse IgG1
NEUT-942CQ Rat Anti-Icos Recombinant Antibody (clone 7E.17G9) FC, FuncS, Neut Rat IgG2b, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-943CQ Rat Anti-Icos Recombinant Antibody (clone mAb0857) Block, FC Rat IgG2

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1727 Rabbit Anti-ICOS Recombinant Antibody (clone DS1727AB) IHC-P Rabbit IgG

Humanized Antibody

CAT Product Name Application Type
VS3-WK1522 Human Anti-ICOS Recombinant Antibody (clone JTX-2011) ELISA, FC Humanized IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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