Recombinant human monoclonal antibody specially binds to human IL-18. This anti-IL-18 antibody h18-108 can be useful not only as epitope-defined antibodies to investigate the mechanism of IL-18 signaling, but also as therapeutic reagents for human disorders involving IL-18.
Figure 1 The expression of IL-18 and IL-18R in the pig anterior pituitary gland.
The house-keeping gene, GAPDH, served as the internal standard.
Nagai, Y., Watanabe, K., Aso, H., Ohwada, S., Muneta, Y., & Yamaguchi, T. (2006). Cellular localization of IL-18 and IL-18 receptor in pig anterior pituitary gland. Domestic animal endocrinology, 30(2), 144-154.
Figure 2 Cellular localization of IL-18 in the pig anterior pituitary gland.
Mirror sections shows the localization of IL-18 in somatotrophs.
Nagai, Y., Watanabe, K., Aso, H., Ohwada, S., Muneta, Y., & Yamaguchi, T. (2006). Cellular localization of IL-18 and IL-18 receptor in pig anterior pituitary gland. Domestic animal endocrinology, 30(2), 144-154.
Figure 3 Double-immunofluorescence method for IL-18 and GH show somatotrophs with IL-18.
Colocalization of IL-18 and IL-18R in the somatotroph.
Nagai, Y., Watanabe, K., Aso, H., Ohwada, S., Muneta, Y., & Yamaguchi, T. (2006). Cellular localization of IL-18 and IL-18 receptor in pig anterior pituitary gland. Domestic animal endocrinology, 30(2), 144-154.
Figure 4 Interference of IL-18 in the ELISA 1 of IL-18BPa.
Percent inhibition of the absorbance signal is shown.
Novick, D., Schwartsburd, B., Pinkus, R., Suissa, D., Belzer, I., Sthoeger, Z., ... & Dinarello, C. A. (2001). A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine, 14(6), 334-342.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0373CL | Human Anti-IL18 Recombinant Antibody (TAB-0373CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-0374CL | Human Anti-IL18 Recombinant Antibody (TAB-0374CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-0373CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0373CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
TAB-0373CL-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (TAB-0373CL-F(E)) | ELISA, FuncS, Inhib | Human Fab |
TAB-0374CL-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (TAB-0374CL-F(E)) | ELISA, FuncS, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0290MZ | Chicken Anti-Interleukin-18 Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1238CQ | Rabbit Anti-IL18 Recombinant Antibody (clone 1072F) | Neut | Rabbit IgG |
NEUT-1239CQ | Rat Anti-Il18 Recombinant Antibody (clone 39-3F) | Neut, WB | Rat IgG2a |
NEUT-1240CQ | Mouse Anti-IL18 Recombinant Antibody (clone CBL670) | Neut | Mouse IgG2a |
NEUT-1241CQ | Rat Anti-Il18 Recombinant Antibody (clone YIGIF74-1G7) | Neut | Rat IgG2a |
NEUT-1242CQ | Rat Anti-Il18 Recombinant Antibody (clone 93-10C) | IP, Neut | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4248 | Rabbit Anti-IL18 Recombinant Antibody (clone SI327DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0064-YC-S(P) | Human Anti-IL18 Recombinant Antibody (clone 2E1); scFv Fragment | ELISA, RIA, IHC, FuncS, Neut | Human scFv |
HPAB-0066-YC-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (HPAB-0066-YC-S(P)) | Neut | Human scFv |
HPAB-0062-YJ-S(P) | Mouse Anti-IL18 Recombinant Antibody (clone 13G9); scFv Fragment | IA, Neut | Mouse scFv |
HPAB-0064-YJ-S(P) | Rat Anti-IL18 Recombinant Antibody (clone 14B7); scFv Fragment | IA, Neut | Rat scFv |
HPAB-0070-YJ-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (HPAB-0070-YJ-S(P)) | ELISA, Neut, IP, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0064-YC-F(E) | Human Anti-IL18 Recombinant Antibody (clone 2E1); Fab Fragment | ELISA, RIA, IHC, FuncS, Neut | Human Fab |
HPAB-0066-YC-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (HPAB-0066-YC-F(E)) | Neut | Humanized Fab |
HPAB-0067-YC-F(E) | Rat Anti-IL18 Recombinant Antibody (clone 2C10); Fab Fragment | Neut | Rat Fab |
HPAB-0062-YJ-F(E) | Mouse Anti-IL18 Recombinant Antibody (clone 13G9); Fab Fragment | IA, Neut | Mouse Fab |
HPAB-0064-YJ-F(E) | Rat Anti-IL18 Recombinant Antibody (clone 14B7); Fab Fragment | IA, Neut | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0229-CN | Human Anti-IL18 Recombinant Antibody (clone 1I1G) | WB, ELISA | Human IgG, λ |
FAMAB-0230-CN | Human Anti-IL18 Recombinant Antibody (clone 3I1E) | WB, ELISA | Human IgG, κ |
FAMAB-0231-CN | Human Anti-IL18 Recombinant Antibody (clone 4I3E) | WB, ELISA | Human IgG, κ |
FAMAB-0232-CN | Human Anti-IL18 Recombinant Antibody (clone 5I4E) | WB, ELISA | Human IgG, κ |
HPAB-0649-CN | Human Anti-IL18 Recombinant Antibody (HPAB-0649-CN) | ELISA, Neut | Humanized IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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