Anti-IL6 (clone BA001) Recombinant Antibody Coupled Liposome (VS-1024-FY109)
CAT#: VS-1024-FY109
Anti-IL-6 antibody-conjugated liposomes may play an important role in the treatment of gliomas. Studies have shown that anti-IL-6R antibodies can reduce the expression of related proteins such as Stat3 in the tumor microenvironment, and may inhibit tumor growth and metastasis. Therefore, this conjugation strategy may have potential anti-tumor effects.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
Normal Tissue
Figure 4 Urinary bladder
Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma; Leukaemia, Early detection of atherosclerotic plaques, Ischemic myocardium in vivo, Prostate Cancer; Neovascular age-related macular degeneration (neovascular AMD); Targeted therapy for diseases such as ulcerative colitis
Product Composition
- Clone
- BA001
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that is engineered to specifically recognize and bind to human interleukin-6 (IL-6). IL-6 is a cytokine that plays a crucial role in inflammation and immune response. By targeting IL-6, this monoclonal antibody can modulate its activity, potentially leading to therapeutic benefits in conditions characterized by excessive or dysregulated IL-6 signaling, such as autoimmune diseases, chronic inflammatory conditions, and certain types of cancers. The development of this antibody involves sophisticated biotechnological methods to ensure its specificity, efficacy, and safety, making it a valuable tool in both research and clinical applications for managing diseases associated with aberrant IL-6 levels.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL6
- Introduction
- This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Interleukin 6
- Full Name
- Interleukin 6
- Gene ID
- 3569
- UniProt ID
- P05231
- Sequence Similarities
- Belongs to the IL-6 superfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N- and O-glycosylated. ( P05231-IL6_HUMAN )
Glycosylation at Asn73 ( NX_P05231 [NX_P05231-1] )
Modification sites at PhosphoSitePlus ( P05231 )
Glycosylation from GlyGen
- Protein Refseq
- XP_005249802.1; XP_054214120.1; XP_054214121.1; NP_000591.1; NP_001305024.1
- Function
- Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism.
Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable).
The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.
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Related Diseases
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone BA001"
- CAT
- Product Name
See other products for "IL6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-239 | Anti-Human IL6 Recombinant Antibody (TAB-239) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-0023CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0023CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-0024CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0024CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-0025CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0025CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-0171CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0171CL) | ELISA, Block, In vivo | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-253 | Anti-Human IL-6 Recombinant Antibody (Olokizumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG4 - kappa |
| TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0172CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0172CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
| TAB-0173CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0173CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
| TAB-678LC | Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) | ELISA, FC, Inhib | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-097 | Anti-Human IL6 Recombinant Antibody (Sirukumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - kappa |
| TAB-0174CL | Human Anti-IL6 Recombinant Antibody (TAB-0174CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0175CL | Human Anti-IL6 Recombinant Antibody (TAB-0175CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0176CL | Human Anti-IL6 Recombinant Antibody (TAB-0176CL) | ELISA, Block, In vivo | Human IgG2 |
| TAB-671LC-F(E) | Anti-human IL6 Fab Fragment (SK2a) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-618 | Recombinant Human Anti-IL-6 Antibody | ELISA, Neut | IgG |
| PABC-232 | Camelid Anti-IL6 Recombinant Antibody (PABC-232) | ELISA | Camelid IgG |
| MOB-0632CT | Recombinant Mouse anti-Human IL6 Monoclonal antibody (6708) | ELISA, WB | |
| HPAB-0164-YJ | Mouse Anti-IL6 Recombinant Antibody (clone 6yl-9) | ELISA, WB, Inhib, Neut | Mouse IgG1, κ |
| HPAB-AP702-YC | Human Anti-IL6 Recombinant Antibody (clone BA001) | ELISA, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-613 | Recombinant Human Anti-IL-6 Antibody scFv Fragment | ELISA, Neut | scFv |
| HPAB-0824-CN-S(P) | Human Anti-IL6 Recombinant Antibody (clone Ab18); scFv Fragment | ELISA | Human scFv |
| HPAB-0825-CN-S(P) | Human Anti-IL6 Recombinant Antibody (clone 18E); scFv Fragment | ELISA | Human scFv |
| HPAB-1105WJ-S(P) | Mouse Anti-IL6 Recombinant Antibody (clone CLB8); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-1758-FY-F(E) | Rat Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-1758-FY-F(E)) | ELISA | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0026CL | Human Anti-IL6 Recombinant Antibody (TAB-0026CL) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) IgG |
| TAB-0026CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-670LC | Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) | ELISA, Inhib | Chimeric antibody (mouse/human) |
| TAB-670LC-F(E) | Anti-human IL6 Fab Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
| VS3-WK1519 | Human Anti-IL6 Recombinant Antibody (clone CLLB8) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1450CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL596) | Neut | Mouse IgG2a |
| NEUT-1451CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL661) | Neut | Mouse IgG2b |
| NEUT-1452CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL553) | WB, Neut | Mouse IgG2a |
| NEUT-1453CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL615) | WB, Neut | Mouse IgG2b |
| NEUT-1454CQ | Mouse Anti-IL6 Recombinant Antibody (clone 1X45) | IHC, Neut | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
| MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
| MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
| MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
| MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
| NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
| NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030LY-F(E) | Humanized Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0030LY-F(E)) | WB | Fab |
| HPAB-1758-FY-S(P) | Rat Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1758-FY-S(P)) | ELISA | Rat scFv |
| HPAB-AP702-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA001); Fab Fragment | ELISA, FuncS | Humanized Fab |
| HPAB-AP703-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA436); Fab Fragment | FuncS (Induce) | Humanized Fab |
| HPAB-AP704-YC-F(E) | Human Anti-IL6 Recombinant Antibody (clone BA802); Fab Fragment | FuncS (Induce) | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-239) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-097 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-097) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H26) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-253) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0166-YC) | ELISA | Camelid VHH |
| HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0167-YC) | ELISA | Camelid VHH |
| HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0168-YC) | ELISA, Inhib | Camelid VHH |
| HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0169-YC) | ELISA, Inhib | Camelid VHH |
| HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0170-YC) | ELISA, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY151 | AbPlus™ Anti-IL6 Magnetic Beads (AS16) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY279 | Mouse Anti-NHP IL6 Recombinant Antibody (clone 6708) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY146 | CytoStream™ Mouse Anti-IL6 Recombinant Antibody (VS-0225-XY146) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY11 | Human Anti-IL6 (clone BA001) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC526 | Recombinant Anti-IL6 Vesicular Antibody, EV Displayed (VS-0425-YC526) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3537 | Anti-Mouse IL6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3538 | Anti-Human IL6 Immunohistochemistry Kit | IHC |
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