Anti-IL6 (clone BA001) Recombinant Antibody Coupled Liposome (VS-1024-FY109) (CAT#: VS-1024-FY109)

• Potential Clinical Applications
• Glioma; Leukaemia, Early detection of atherosclerotic plaques, Ischemic myocardium in vivo, Prostate Cancer; Neovascular age-related macular degeneration (neovascular AMD); Targeted therapy for diseases such as ulcerative colitis

• Clone
• BA001

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that is engineered to specifically recognize and bind to human interleukin-6 (IL-6). IL-6 is a cytokine that plays a crucial role in inflammation and immune response. By targeting IL-6, this monoclonal antibody can modulate its activity, potentially leading to therapeutic benefits in conditions characterized by excessive or dysregulated IL-6 signaling, such as autoimmune diseases, chronic inflammatory conditions, and certain types of cancers. The development of this antibody involves sophisticated biotechnological methods to ensure its specificity, efficacy, and safety, making it a valuable tool in both research and clinical applications for managing diseases associated with aberrant IL-6 levels.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• IL6

• Introduction
• This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.

• Alternative Names
• Interleukin 6

• Full Name
• Interleukin 6

• Gene ID
• 3569

• UniProt ID
• P05231

• Sequence Similarities
• Belongs to the IL-6 superfamily.

• Cellular Localization
• Secreted

• Post Translation Modifications
• N- and O-glycosylated. ( P05231-IL6_HUMAN )
  Glycosylation at Asn73 ( NX_P05231 [NX_P05231-1] )
  Modification sites at PhosphoSitePlus ( P05231 )
  Glycosylation from GlyGen

• Protein Refseq
• XP_005249802.1; XP_054214120.1; XP_054214121.1; NP_000591.1; NP_001305024.1

• Function
• Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism.
  Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable).
  The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.

• HPAB-AP702-YC
• Human Anti-IL6 Recombinant Antibody (clone BA001)

• HPAB-AP702-YC-S(P)
• Human Anti-IL6 Recombinant Antibody (clone BA001); scFv Fragment

• HPAB-AP702-YC-F(E)
• Human Anti-IL6 Recombinant Antibody (clone BA001); Fab Fragment

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