Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); scFv Fragment

Name: Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); scFv Fragment
SKU: HPAB-AP752-YC-S(P)
Rating: 5 (1 reviews)

CAT#: HPAB-AP752-YC-S(P)

Provided are fully human monoclonal antibodies that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. The antibody can be used for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg

Normal Tissue Figure 2 IHC staining of human pancreas

Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg

Normal Tissue Figure 4 Colon

Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg

Normal Tissue Figure 6 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg

Normal Tissue Figure 7 Testis

Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg

Normal Tissue Figure 8 Lymph node

Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

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Specifications

Host Species
Human

Type
Human scFv

Specificity
Human NOTCH1

Species Reactivity
Human

Clone
hN1wc49

Applications
ELISA, FC

Related Disease
Pathological hyperproliferative oncogenic disorders

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1, Translocation-Associated (Drosophila); Notch Homolog 1, Translocation-Associated

Gene ID
4851

UniProt ID
P46531

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Related Diseases

Breast Cancer

Endocrine Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-AP752-YC-S(P).pdf

MSDS

MSDS - HPAB-AP752-YC-S(P).pdf

COA

Certificate of Analysis Lookup

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