Anti-PDCD1 Antibody Prodrug, Protease Activated (VS-1025-YC76)
CAT#: VS-1025-YC76
The Anti-PDCD1 Antibody Prodrug, Protease Activated (VS-1025-YC76) is an antibody prodrug comprised of a recombinant mouse antibody targeting human PDCD1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to PDCD1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to PDCD1 effectively. PDCD1, or PD-1 (Programmed Death 1), is the inhibitory immune checkpoint receptor found on the surface of T-cells and is the target for a major class of immunotherapies. When PD-1 binds to its ligands (PD-L1/PD-L2) on tumor cells, it effectively paralyzes the T-cell, allowing the tumor to evade immune destruction. Blockade of PD-1 with therapeutic antibodies releases the T-cells to attack the cancer.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_9_8.jpg
Normal Tissue
Figure 2 Tonsil
Germinal center cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_6_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000188389-PDCD1
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human PDCD1
- Target
- PDCD1
- Species Reactivity
- Human
- Isotype
- IgG
- Epitope
- PD1-ECD (aa 1-167)
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
- Alternative Names
- PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
- Gene ID
- 5133
- UniProt ID
- Q15116
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-0964CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0964CL) | ELISA, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
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| TAB-0965CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0965CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
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| TAB-0966CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0966CL) | ELISA | Humanized antibody |
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| TAB-0967CL | Anti-Human PDCD1 Recombinant Antibody (AB7) | ELISA, WB |
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| TAB-0968CL | Anti-Human PDCD1 Recombinant Antibody (cAB7) | ELISA, WB | Chimeric antibody (mouse/human) |
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| TAB-0969CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0969CL) | FC, ELISA | Mouse IgG |
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| TAB-0970CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0970CL) | ELISA, FuncS | Human IgG1 |
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| TAB-0971CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0971CL) | ELISA | Human IgG |
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| TAB-0974CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0974CL) | ELISA | Chimeric (Mouse/Human) antibody |
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| TAB-0975CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0975CL) | ELISA | Humanized antibody |
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| TAB-0977CL | Anti-Human PDCD1 Recombinant Antibody (949gH1a) | FC | Humanized antibody |
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| TAB-0974CL-S(P) | Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (TAB-0974CL-S(P)) | ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
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| NEUT-1829CQ | Recombinant Rat Anti-Pdcd1 Antibody (RMP1-14) | BL, WB | IgG2a |
| CAT | Product Name | Application | Type |
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| NEUT-1830CQ | Recombinant Rat Anti-Pdcd1 Antibody (NEUT-1830CQ) | BL | IgG2b |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1835CQ | Recombinant Mouse Anti-PDCD1 Antibody (9X21) | Neut, WB | IgG2 |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0184-YC | Mouse Anti-PDCD1 Recombinant Antibody (HPAB-0184-YC) | FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0185-YC | Mouse Anti-PDCD1 Recombinant Antibody (HPAB-0185-YC) | FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-YC-S(P) | Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0184-YC-S(P)) | FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0185-YC-S(P) | Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0185-YC-S(P)) | FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0186-YC-S(P) | Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0186-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0187-YC-S(P) | Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0187-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0184-YC-F(E) | Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0184-YC-F(E)) | FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0185-YC-F(E) | Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0185-YC-F(E)) | FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0186-YC-F(E) | Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0186-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0187-YC-F(E) | Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0187-YC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-900 | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-900) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-028ML | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-012ML | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-012ML) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-770 | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-770) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H55 | Afuco™ Human Anti-PDCD1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H55) | FuncS, IF, Neut, ELISA, FC | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0252-WJ | Rat Anti-PDCD1 Recombinant Antibody (HPAB-0252-WJ) | ELISA | Rat IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0309-YC-VHH | Recombinant Humanized Anti-PDCD1 Single Domain Antibody (HPAB-N0309-YC-VHH) | FC, ELISA | Humanized VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY39 | Rabbit Anti-PDCD1 Agonistic Antibody (VS-0724-XY39) | ELISA, Agonistic assays | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY59 | Human Anti-PDCD1 Agonistic Antibody (clone 949) | ELISA, BLI, FC, Agonistic assays | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1287 | AbPlus™ Anti-PDCD1 Magnetic Beads (VS-0724-YC1287) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC141 | Human Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC141), CDC Enhanced | IP, IF, FuncS, FC, Neut, ELISA, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC142 | Mouse Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC142), CDC Enhanced | ELISA, Block, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY87 | Mouse Anti-NHP PDCD1 Recombinant Antibody (clone EH12.2H7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY34 | Human Anti-PDCD1 (clone PD1-17) scFv-Fc Chimera | ELISA, FuncS, Block, ADCC, CDC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY173 | CytoStream™ Mouse Anti-PDCD1 Recombinant Antibody (VS-0225-XY173) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC457 | Recombinant Anti-PDCD1 Vesicular Antibody, EV Displayed (VS-0425-YC457) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5251 | Anti-PDCD1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5252 | Anti-Mouse PDCD1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC224 | Recombinant Anti-PDCD1 (AA 25-34 x AA 74-99) Biparatopic Antibody, Tandem scFv | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC19 | SmartAb™ Recombinant Anti-PDCD1 pH-dependent Antibody (VS-0825-YC19) | IF, IP, Neut, ELISA, FC, ICC | Human IgG4 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC278 | SmartAb™ Recombinant Anti-PDCD1 pH-dependent Antibody (VS-0825-YC278) | ELISA, ICC, IP, IF, FC, Neut | Human IgG1 kappa |
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