Anti-PDCD1 Antibody Prodrug, Protease Activated (VS-1025-YC76)

Name: Anti-PDCD1 Antibody Prodrug, Protease Activated (VS-1025-YC76)
SKU: VS-1025-YC76
Rating: 5 (1 reviews)

CAT#: VS-1025-YC76

The Anti-PDCD1 Antibody Prodrug, Protease Activated (VS-1025-YC76) is an antibody prodrug comprised of a recombinant mouse antibody targeting human PDCD1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to PDCD1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to PDCD1 effectively. PDCD1, or PD-1 (Programmed Death 1), is the inhibitory immune checkpoint receptor found on the surface of T-cells and is the target for a major class of immunotherapies. When PD-1 binds to its ligands (PD-L1/PD-L2) on tumor cells, it effectively paralyzes the T-cell, allowing the tumor to evade immune destruction. Blockade of PD-1 with therapeutic antibodies releases the T-cells to attack the cancer.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_9_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000188389-PDCD1

❮

❯

Specifications

Host Animal
Mouse

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human PDCD1

Target
PDCD1

Species Reactivity
Human

Isotype
IgG

Epitope
PD1-ECD (aa 1-167)

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Alternative Names
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1

Gene ID
5133

UniProt ID
Q15116

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Datasheet

Datasheet - VS-1025-YC76.pdf

MSDS

MSDS - VS-1025-YC76.pdf

COA

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