Human Anti-PDCD1 (clone PD1-17) scFv-Fc Chimera (CAT#: VS-0125-FY34)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• PD1-17

• Applications
• ELISA, Functional Assay, Blocking, Antibody-dependent cellular cytotoxicity, Complement-dependent cytolysis

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The functions of anti-scFv-Fc generally include the ability to specifically bind to the target antigen, block its interaction with ligands, and potentially activate the immune system through binding to the Fc region (for example, mediating antibody-dependent cellular cytotoxicity, ADCC, or complement-dependent cytotoxicity, CDC).

• Alternative Names
• Programmed Cell Death 1; Systemic Lupus Erythematosus Susceptibility 2; Protein PD-1; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1

• Gene ID
• 5133

• UniProt ID
• Q15116

• Cellular Localization
• Cell membrane; Membrane

• Post Translation Modifications
• Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation.
  Ubiquitinated via 'Lys-48'-linked polyubiquitin chains.
  Tyrosine phosphorylated at Tyr-223 (within ITIM motif) and Tyr-248 (ITSM motif) upon ligand binding. Phosphorylation at Tyr-248 promotes the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.
  N-glycosylation at Asn-58 contains at least two N-acetylglucosamine units and one fucose.

• Protein Refseq
• NP_005009.2

• Function
• Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.
  Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.
  Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
  Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
  The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival.
  The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function.
  The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• TAB-0961CL
• Anti-Human PDCD1 Recombinant Antibody (PD1-17)

• TAB-0961CL-S(P)
• Anti-Human PDCD1 Recombinant Antibody scFv Fragment (PD1-17)

• TAB-0961CL-F(E)
• Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17)

• VS-1024-FY255
• Anti-PDCD1 (clone PD1-17) Recombinant Antibody Coupled Liposome (VS-1024-FY255)

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