1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Human Anti-PDCD1 (clone PD1-17) scFv-Fc Chimera

    CAT#: VS-0125-FY34

    This product is an anti-PDCD1 single-chain antibody-Fc fusion protein (scFv-Fc) that can specifically recognize and bind to the target antigen, effectively blocking its interaction with the ligand. Through this blocking effect, the antibody not only weakens the immune evasion capability of tumor cells and promotes the immune system's recognition and attack on tumor cells, but it may also induce immune effects through its Fc region, facilitating antibody-dependent cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Therefore, this antibody holds promise in tumor immunotherapy, with potential to enhance treatment efficacy and improve patient prognosis.

    Gene Expression
    ❮
    Figure 1 Lymph node Figure 2 Tonsil Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
    ❯

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Species Reactivity
    • Human
    • Clone
    • PD1-17
    • Applications
    • ELISA, Functional Assay, Blocking, Antibody-dependent cellular cytotoxicity, Complement-dependent cytolysis
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Stabilizer
    • No Stabilizers
    • Sterility
    • 0.2 μM filtered
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The functions of anti-scFv-Fc generally include the ability to specifically bind to the target antigen, block its interaction with ligands, and potentially activate the immune system through binding to the Fc region (for example, mediating antibody-dependent cellular cytotoxicity, ADCC, or complement-dependent cytotoxicity, CDC).

    Target

    • Alternative Names
    • Programmed Cell Death 1; Systemic Lupus Erythematosus Susceptibility 2; Protein PD-1; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1
    • Cellular Localization
    • Cell membrane; Membrane
    • Post Translation Modifications
    • Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation.
      Ubiquitinated via 'Lys-48'-linked polyubiquitin chains.
      Tyrosine phosphorylated at Tyr-223 (within ITIM motif) and Tyr-248 (ITSM motif) upon ligand binding. Phosphorylation at Tyr-248 promotes the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.
      N-glycosylation at Asn-58 contains at least two N-acetylglucosamine units and one fucose.
    • Function
    • Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.
      Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.
      Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
      Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
      The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival.
      The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function.
      The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
    REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
    Inquiry
    Navs

    Customer Review

    Submit a review or a question

    There are currently no Customer reviews or questions for VS-0125-FY34. Click the button above to contact us or submit your feedback about this product.

    Submit Your Publication

    Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

    Article title:
    DOI/PubMed URL:
    Email:
    Name:

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0125-FY34.pdf

    MSDS

    MSDS - VS-0125-FY34.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Secondary Antibody

    • CAT
    • Product Name

    Isotype Control

    • CAT
    • Product Name

    See other products for "Clone PD1-17"

    • CAT
    • Product Name

    See other products for "PDCD1"

    Select a product category from the dropdown menu below to view related products.

    CAT Product Name Application Type
    TAB-900 Anti-Human PD-1/PDCD1/CD279 Recombinant Antibody (TAB-900) IP, IF, FuncS, FC, Neut, ELISA, ICC IgG1 - kappa
    TAB-0975CL Human Anti-PDCD1 Recombinant Antibody (TAB-0975CL) ELISA Humanized antibody
    TAB-0966CL-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0966CL-F(E)) ELISA Humanized Fab
    TAB-0975CL-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0975CL-F(E)) ELISA Humanized Fab
    TAB-0977CL-F(E) Anti-Human PDCD1 Recombinant Antibody Fab Fragment (949gH1a) FC Humanized antibody
    CAT Product Name Application Type
    TAB-0968CL Anti-Human PDCD1 Recombinant Antibody (cAB7) ELISA, WB Chimeric antibody (mouse/human)
    TAB-0968CL-S(P) Anti-Human PDCD1 Recombinant Antibody scFv Fragment (cAB7) ELISA, WB Chimeric antibody (mouse/human)
    TAB-0974CL-S(P) Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (TAB-0974CL-S(P)) ELISA Human scFv
    TAB-0968CL-F(E) Anti-Human PDCD1 Recombinant Antibody Fab Fragment (cAB7) ELISA, WB Chimeric antibody (mouse/human)
    TAB-0974CL-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0974CL-F(E)) ELISA Chimeric (Mouse/Human) Fab
    CAT Product Name Application Type
    TAB-0961CL-F(E) Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17) ELISA Human antibody
    TAB-0962CL-F(E) Anti-Mouse Pdcd1 Recombinant Antibody Fab Fragment (PD1-F2) ELISA Human antibody
    TAB-0970CL-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0970CL-F(E)) ELISA Human Fab
    TAB-0971CL-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0971CL-F(E)) ELISA Human Fab
    TAB-0972CL-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0972CL-F(E)) ELISA Human Fab
    CAT Product Name Application Type
    TAB-0963CL-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0963CL-F(E)) FC Mouse Fab
    TAB-0964CL-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0964CL-F(E)) ELISA Mouse Fab
    TAB-0965CL-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0965CL-F(E)) ELISA Mouse Fab
    TAB-0967CL-F(E) Anti-Human PDCD1 Recombinant Antibody Fab Fragment (AB7) ELISA, WB
    TAB-0969CL-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0969CL-F(E)) FC, ELISA Mouse Fab
    CAT Product Name Application Type
    NEUT-1827CQ Recombinant Rat Anti-Pdcd1 Antibody (29F.1A12) BL, FC IgG2a
    NEUT-1828CQ Recombinant Hamster Anti-Pdcd1 Antibody (J43) BL, WB IgG
    NEUT-1829CQ Recombinant Rat Anti-Pdcd1 Antibody (RMP1-14) BL, WB IgG2a
    NEUT-1830CQ Recombinant Rat Anti-Pdcd1 Antibody (NEUT-1830CQ) BL IgG2b
    NEUT-1831CQ Recombinant Hamster Anti-Pdcd1 Antibody (MAB0839) BL, FC IgG2
    CAT Product Name Application Type
    NEUT-1832CQ Recombinant Mouse Anti-PDCD1 Antibody (CBL151) Neut, WB IgG2
    NEUT-1834CQ Recombinant Human Anti-PDCD1 Antibody (CBL1021) Neut IgG1, κ
    NEUT-1835CQ Recombinant Mouse Anti-PDCD1 Antibody (9X21) Neut, WB IgG2
    CAT Product Name Application Type
    MOR-2622 Hi-Affi™ Recombinant Rabbit Anti-PDCD1 Monoclonal Antibody (DS2622AB) IHC IgG
    CAT Product Name Application Type
    HPAB-0184-YC-S(P) Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0184-YC-S(P)) FC, FuncS Mouse scFv
    HPAB-0185-YC-S(P) Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0185-YC-S(P)) FC, FuncS Mouse scFv
    HPAB-0186-YC-S(P) Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0186-YC-S(P)) ELISA, FC Mouse scFv
    HPAB-0187-YC-S(P) Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0187-YC-S(P)) ELISA, FC Mouse scFv
    HPAB-0188-YC-S(P) Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0188-YC-S(P)) ELISA, FC Humanized scFv
    CAT Product Name Application Type
    HPAB-0184-YC-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0184-YC-F(E)) FC, FuncS Mouse Fab
    HPAB-0185-YC-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0185-YC-F(E)) FC, FuncS Mouse Fab
    HPAB-0186-YC-F(E) Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0186-YC-F(E)) ELISA, FC Mouse Fab
    HPAB-0187-YC-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0187-YC-F(E)) ELISA, FC Human Fab
    HPAB-0188-YC-F(E) Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0188-YC-F(E)) ELISA, FC Humanized Fab
    CAT Product Name Application Type
    HPAB-0517LY Human Anti-PDCD1 Recombinant Antibody (clone MIL75) ELISA, Block Human IgG1
    HPAB-0518LY Human Anti-PDCD1 Recombinant Antibody (clone CBL011LY) ELISA, Block Human IgG1
    HPAB-0519LY Mouse Anti-PDCD1 Recombinant Antibody (clone 1D2) ELISA, Block Mouse IgG
    HPAB-0520LY Mouse Anti-PDCD1 Recombinant Antibody (clone 1G4) ELISA, Block Mouse IgG
    HPAB-0521LY Mouse Anti-PDCD1 Recombinant Antibody (clone 1H10) ELISA, Block Mouse IgG
    CAT Product Name Application Type
    AFC-TAB-900 Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-900) IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
    AFC-TAB-028ML Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028ML) ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
    AFC-TAB-012ML Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-012ML) ELISA, IHC, FC, IP, IF, BL ADCC enhanced antibody
    AFC-TAB-770 Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-770) IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
    AFC-TAB-H55 Afuco™ Human Anti-PDCD1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H55) FuncS, IF, Neut, ELISA, FC IgG1, κ
    CAT Product Name Application Type
    HPAB-0252-WJ Rat Anti-PDCD1 Recombinant Antibody (HPAB-0252-WJ) ELISA Rat IgM
    CAT Product Name Application Type
    HPAB-N0309-YC-VHH Recombinant Humanized Anti-PDCD1 Single Domain Antibody (HPAB-N0309-YC-VHH) FC, ELISA Humanized VHH
    CAT Product Name Application Type
    VS-0724-XY39 Rabbit Anti-PDCD1 Agonistic Antibody (VS-0724-XY39) ELISA, Agonistic assays Rabbit IgG
    VS-0724-XY59 Human Anti-PDCD1 Agonistic Antibody (clone 949) ELISA, BLI, FC, Agonistic assays Human IgG
    CAT Product Name Application Type
    VS-0724-YC1287 AbPlus™ Anti-PDCD1 Magnetic Beads (VS-0724-YC1287) IP, Protein Purification
    CAT Product Name Application Type
    VS-0924-YC141 Human Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC141), CDC Enhanced IP, IF, FuncS, FC, Neut, ELISA, CDC Antibody hexamer
    VS-0924-YC142 Mouse Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC142), CDC Enhanced ELISA, Block, CDC Antibody hexamer
    CAT Product Name Application Type
    VS-1024-XY87 Mouse Anti-NHP PDCD1 Recombinant Antibody (clone EH12.2H7) FC Mouse IgG1, kappa
    CAT Product Name Application Type
    VS-0225-XY173 CytoStream™ Mouse Anti-PDCD1 Recombinant Antibody (VS-0225-XY173) FC Mouse IgG1, kappa
    CAT Product Name Application Type
    VS-0425-YC457 Recombinant Anti-PDCD1 Vesicular Antibody, EV Displayed (VS-0425-YC457) ELISA, FC, Neut, Cell-uptake
    CAT Product Name Application Type
    VS-0525-XY5251 Anti-PDCD1 Immunohistochemistry Kit IHC
    VS-0525-XY5252 Anti-Mouse PDCD1 Immunohistochemistry Kit IHC
    CAT Product Name Application Type
    VS-0525-YC224 Recombinant Anti-PDCD1 (AA 25-34 x AA 74-99) Biparatopic Antibody, Tandem scFv ELISA Tandem scFv
    Specific Inquiry
    Go to compare Add to compare
    Request
    Custom Production     custom production
    See Our Custom Production in Action
    Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE
    Download the full case study
    Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE
    Download the full case study

    Popular Products

    Figure 1 Anti-P. aeruginosa psl Antibody in SDS-PAGE

    Recombinant Anti-P. aeruginosa psl Antibody (CAT# MOB-736)
    Application: WB, IP, FuncS

    Figure 4 Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) in ELISA

    Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) (CAT# TAB-196)
    Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

    Figure 5 Anti-Human ITGAV Recombinant Antibody (TAB-H01) in ELISA

    Anti-Human ITGAV Recombinant Antibody (Abituzumab) (CAT# TAB-H01)
    Application: Inhib, Agonist

    Figure 2 Anti-Human CD30 Recombinant Antibody (TAB-144) in ELISA

    Anti-Human CD30 Recombinant Antibody (Iratumumab) (CAT# TAB-144)
    Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

    Figure 3 Anti-ERBB3 Recombinant Antibody (TAB-892) in DB

    Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) (CAT# TAB-892)
    Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

    Figure 2 Anti-Human CD4 Therapeutic Antibody (TAB-146) in ELISA

    Anti-Human CD4 Recombinant Antibody (TAB-146) (CAT# TAB-146)
    Application: FuncS, IF, Neut, ELISA, FC, IP, ICC

    Figure 3 Anti-Human EGFR Antibody (TAB-003) in DB

    Anti-Human EGFR Recombinant Antibody (Cetuximab) (CAT# TAB-003)
    Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

    Figure 5 Human Anti-MET Recombinant Antibody (PABL-271) in DB

    Human Anti-MET Recombinant Antibody (PABL-271) (CAT# PABL-271)
    Application: WB, Block, FuncS

    Figure 4 Mouse Anti-OPN Recombinant Antibody; Fab Fragment (PFBL-291) in WB

    Mouse Anti-OPN Recombinant Antibody (clone 23C3); Fab Fragment (CAT# PFBL-291)
    Application: WB, ELISA, FuncS

    Figure 1 Recombinant Mouse Anti-UPAR Antibody (ATN615) (PABC-130) in WB

    Mouse Anti-UPAR Recombinant Antibody (clone ATN615) (CAT# PABC-130)
    Application: ELISA, IP, WB, IHC, IF, FuncS

    Figure 5 Recombinant Human Anti-EBV BLLF1 Antibody (PABZ-138) in DB

    Recombinant Human Anti-EBV BLLF1 Antibody (72A1) (CAT# PABZ-138)
    Application: Neut, ELISA

    Figure 4 Anti-Human CD59 Recombinant Antibody Fab Fragment (TAB-321LC-F(E)) in DB

    Anti-Human CD59 Recombinant Antibody Fab Fragment ((ch)AR36A36.11.1) (CAT# TAB-321LC-F(E))
    Application: WB, ELISA

    Figure 2 Anti-FGFR1 Therapeutic Antibody (FR1-H7) (TAB-052WM) in ELISA

    Anti-Human FGFR1 Recombinant Antibody (FR1-H7) (CAT# TAB-052WM)
    Application: ELISA, Neut

    Figure 3 Anti-Human IgE Antibody (TAB-095ZJ) in ELISA

    Anti-Human IgE Single Domain Antibody (TAB-095ZJ), Research Grade Biosimilar (CAT# TAB-095ZJ)
    Application: ELISA, Inhib, FC

    Figure 3 Human Anti-APLNR Recombinant Antibody (TAB-0938CLV) in FACS

    Human Anti-APLNR Recombinant Antibody (TAB-0938CLV) (CAT# TAB-0938CLV)
    Application: ELISA

    Figure 3 Anti-CD27 Recombinant Antibody (MOB-096LC) in DB

    Human Anti-CD27 Recombinant Antibody (MOB-096LC) (CAT# MOB-096LC)
    Application: ELISA, FuncS, WB

    Figure 4 Anti-Human CD47 Antibody (HPAB-0008-FY) in HPLC

    Human Anti-CD47 Recombinant Antibody (HPAB-0008-FY) (CAT# HPAB-0008-FY)
    Application: ELISA, PD, Activ, PK, Stim

    Figure 1 Recombinant Human Anti-HBV preS1 Antibody (PABC-406) in SDS-PAGE

    Recombinant Human Anti-HBV preS1 Antibody (PABC-406) (CAT# PABC-406)
    Application: Neut, IHC, Activ, FuncS, IF, ELISA

    Figure 2 Recombinant Human Anti-WTA Antibody(HPAB-N0298-YC) in HPLC

    Human Anti-WTA Recombinant Antibody (HPAB-N0298-YC) (CAT# HPAB-N0298-YC)
    Application: FuncS

    Figure 5 Mouse Anti-SERPINA1 Recombinant Antibody (PABJ-0203) in ELISA

    Mouse Anti-SERPINA1 Recombinant Antibody (clone 2H2) (CAT# PABJ-0203)
    Application: IF, FuncS

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

    Send Inquiry

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    Go to compare

    Go to compare