Anti-Human PDCD1 Recombinant Antibody (PD1-17) (CAT#: TAB-0961CL)
This antibody can inhibit binding of PD-L1 to PD-1 and modulate immune responses mediated by TcR and CD28, in particular. It may be used in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
Specific Inquiry
ELISA
Figure 1 Reactivity of IgG-converted antibodies with human or mouse PD-1 as determined by ELISA.
ELISA
Figure 2 An ELISA demonstrating that selected PD-1 antibodies inhibit binding of PD-L1 to PD-1.
FuncS
Figure 3 T-cell proliferation assays demonstrating that co-engagement by TcR and anti-PD-1 antibody PD1-17 or PD-L1.
Fc reduces proliferation. Co-engagement by TcR and anti-PD-1 J110 has no effect on proliferation.
FuncS
Figure 4 Enhanced proliferation of primary T cells by PD1-17 in a soluble form.
Specifications
- Immunogen
- Soluble PD-1 fusion protein
- Host Species
- Human
- Derivation
- scFv phagemid library
- Type
- Human antibody
- Specificity
- Human
- Clone
- PD1-17
- Applications
- ELISA, FuncS
- Related Disease
- Rheumatoid arthritis (RA)
Applications
- Application Notes
- The antibody was validated for ELISA, Functional Assay. For details, refer to Published Data.
Target
- Alternative Names
- PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
- Gene ID
- 5133
- UniProt ID
- Q15116
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H55 | Human Anti-PDCD1 Recombinant Antibody (TAB-H55) | Inhib, Agonist | IgG4, κ |
| TAB-0966CL-F(E) | Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0966CL-F(E)) | ELISA | Humanized Fab |
| TAB-0975CL-F(E) | Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (TAB-0975CL-F(E)) | ELISA | Humanized Fab |
| TAB-0977CL-F(E) | Anti-Human PDCD1 Recombinant Antibody Fab Fragment (949gH1a) | FC | Humanized antibody |
| TAB-012ML | Anti-Human PDCD1 Recombinant Antibody (TAB-012ML) | ELISA, IHC, FC, IP, IF, BL | IgG4, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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