Human Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC141), CDC Enhanced

Name: Human Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC141), CDC Enhanced
SKU: VS-0924-YC141
Rating: 5 (1 reviews)

CAT#: VS-0924-YC141

The product is a human anti-PDCD1 antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets human PDCD1 and incorporates hexamerization-enhancing mutations, which facilitate hexamer formation to achieve optimal C1q binding and boost complement-dependent cytotoxicity (CDC).

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_9_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000188389-PDCD1

❮

❯

Specifications

Host Species
Human

Derivation
Humanized

Type
Antibody hexamer

Specificity
Human PDCD1

Species Reactivity
Human

Molecule Class
~ 900 kDa

Applications
IP, IF, FuncS, FC, Neut, ELISA, CDC

Conjugate
None

Related Disease
Hodgkin lymphoma

Product Property

Clonality
Monoclonal

Purification
Protein A purified

Purity
>95% determined as SDS-PAGE and SEC-HPLC

Aggregation
<5%

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Programmed Cell Death 1; Systemic Lupus Erythematosus Susceptibility 2; Protein PD-1; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1;

Gene ID
5133

UniProt ID
Q15116

Long Name
Programmed Cell Death 1

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Datasheet

Datasheet - VS-0924-YC141.pdf

MSDS

MSDS - VS-0924-YC141.pdf

COA

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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