Mouse Anti-PLCG1 Recombinant Antibody (clone F7) (CAT#: FAMAB-0249YC)
Provided is a antibody as a blocker for PLC-γ1 mediated signaling. Antibody, designated F7, bound to PLC-γ1 with high affinity in vitro. F7 also bound to PLC-γ1 in vivo and altered the distribution pattern of PLC-g1 from the cytoplasm to the intracellular aggregates, where F7 was localized. Moreover, F7 interrupted the EGF-induced translocation of PLC-γ1 from the cytosol to the membrane rue and attenuated EGF-induced inositol phosphates generation and intracellular calcium mobilization.
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ELISA
Figure 1 F7-scFv binds to PLC-γ1.
Purified PLC-γ1 was coated on a ELISA plate and Xpress tagged-F7-scFv was applied.
IP
Figure 2 F7-scFv binds to PLC-γ1.
Purified Xpress tagged-F7-scFv or CEA79-scFv were added to COS-7 cell lysate, and PLC-γ1 was immunoprecipitated from the mixture with anti-PLC-γ1 antibody.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- PLCG1
- Clone
- F7
- Applications
- ELISA, IP, WB
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PLCG1; Phospholipase C gamma 1; PLC-γ1; PLCgamma1
- Gene ID
- 103245987
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1663z | Mouse Anti-PLCG1 Recombinant Antibody (clone 26H9) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| MRO-1618-CN | Recombinant Rabbit Anti-PLCG1 Monoclonal Antibody (CBACN-589) | WB, IF, IP | Rabbit IgG |
| VS3-FY2113 | Rabbit Anti-PLCG1 Recombinant Antibody (clone R81-6X-8) | WB, IF, IP | Rabbit IgG |
| VS13-YC909 | Rabbit Anti-PLCG1 Recombinant Antibody (VS13-YC909) | WB, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR626 | Mouse Anti-PLCG1 Recombinant Antibody (clone 2F3D11) | WB, FC | Mouse IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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