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    PLCG1

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    For Research Use Only. Not For Clinical Use.


    Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
    Protein class

    Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, RAS pathway related proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Astrocytes)

    Immune cell specificity

    Group enriched (MAIT T-cell, gdT-cell, naive CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell, memory CD8 T-cell, T-reg, NK-cell)

    Cell line specificity

    Low cell line specificity

    Interaction

    Interacts with AGAP2 via its SH3 domain. Interacts (via SH2 domain) with RET. Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with AXL, FLT4 and KIT. Interacts with RALGPS1. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C (By similarity). Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with SYK; activates PLCG1. Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome. (Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein.

    Molecular function

    Hydrolase, Transducer

    More Types Infomation
    Related Signaling Pathways
    cAMP Signaling Pathway cAMP Signaling Pathway
    ErbB Signaling Pathway ErbB Signaling Pathway
    FcεR1 Signaling Pathway FcεR1 Signaling Pathway
    TCR Signaling Pathway TCR Signaling Pathway
    Related Diseases
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Morphine Addiction Morphine Addiction
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