Human Anti-SNCA Recombinant Antibody (VS-0224-FY15) (CAT#: VS-0224-FY15)

This monoclonal antibody has been developed to selectively target soluble human α-synuclein aggregates. The antibody binds to α-synuclein C-terminal residues 121-127. It has demonstrated outstanding in vivo efficacy. The antibody exhibits selective binding to α-synuclein from human (EC₅₀ = 40 pM), cynomolgus monkey (EC₅₀ = 45 pM), and rabbit (EC₅₀ = 189 pM). Notably, no specific binding was observed for α-synuclein from rat and mouse (EC₅₀> 150 nM). The antibody did not bind to Aβ protofibrils, monomeric β-synuclein or γ-synuclein.

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Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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We require custom production
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • Hydroxynonenal (HNE) stabilized complexes of α-synuclein
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Human IgG4 (S241P), κ
  • Specificity
  • The antibody selectively targets soluble toxic α-synuclein aggregates with a picomolar affinity.
  • Species Reactivity
  • Human, Cynomolgus, Rabbit
  • Applications
  • Western Blot, Immunohistochemistry, ELISA, Immunoprecipitation, Dot blot, SPR assay, Functional assay
  • Conjugate
  • Unconjugated
  • Related Disease
  • Alzheimer's disease

Product Property

  • Purity
  • >95%
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Dot blot: 0.1 µg/mL
    Western blot: 0.4 µg/mL

Target

  • Alternative Names
  • Synuclein Alpha; Synuclein, Alpha (Non A4 Component Of Amyloid Precursor); Alpha-Synuclein; PARK1; NACP; Parkinson Disease (Autosomal Dominant, Lewy Body) 4; Non A4 Component Of Amyloid Precursor; Non-A4 Component Of Amyloid Precursor

Recommended Products

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
IAB-B031(A) Recombinant Anti-human SNCA Intrabody [(D-Arg)9] FC, IF, FuncS scFv-(D-Arg)9
IAB-B031(G) Recombinant Anti-human SNCA Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
IAB-B031(T) Recombinant Anti-human SNCA Intrabody [Tat] ELISA, IF, Neut, FuncS scFv-Tat

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