Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Fresolimumab), ADCC Enhanced (CAT#: AFC-TAB-140)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to TGF-beta. Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Figure 3 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Figure 4 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
Specifications
- Immunogen
- A synthetic peptide (17 aa) derived from C terminal human TGF beta 3 protein.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Fresolimumab
- Applications
- Neut, ELISA, IF, IP, FuncS, FC
- Conjugate
- Unconjugated
- Generic Name
- Fresolimumab
- Related Disease
- Idiopathic pulmonary fibrosis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Fresolimumab; 948564-73-6; GC1008; GC1008; TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB;
- Gene ID
- 7040
- UniProt ID
- P01137
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Fresolimumab"
Anti-Human TGF-β Recombinant Antibody (Fresolimumab)Recombinant monoclonal antibody to TGF-beta. Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
See other products for "Tgfb1"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-344 | Human Anti-TGFB1 Recombinant Antibody (PSBL-344); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0018-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0018-YC-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0037-WJ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0037-WJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0737LY-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0737LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1188LY-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-1188LY-S(P)) | ELISA, WB, ICC, IP | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-632CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-633CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-633CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-634CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-634CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-635CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-636CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-636CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-637CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-637CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-638CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-638CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-639CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-639CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-1110MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1111MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy7 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1112MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1113MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1114MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to Rhodamine | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-28G11) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-20B9) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 2Ar2) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-0018-YC) | ELISA, Neut | Humanized IgG, κ |
| HPAB-0492-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0492-CN) | ELISA, FC, IF, Neut | Human IgG2 |
| HPAB-0493-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0493-CN) | ELISA, FC, IF, Neut | Human IgG2 |
| FN-255CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL-1349) | IP, WB | Mouse IgG1 |
| HPAB-2107-FY | Human Anti-TGFB1 Recombinant Antibody (clone 31G9) | ELISA | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0392-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0392-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0393-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0393-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0394-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0394-YC-F(E)) | IHC, Neut, FuncS | Human Fab |
| HPAB-2101-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone SL15A); Fab Fragment | Inhib, ELISA | Human Fab, κ |
| HPAB-2102-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone SL15S); Fab Fragment | Inhib, ELISA | Human Fab, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Metelimumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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