Anti-TNFRSF9 (clone LOB12.3) Recombinant Antibody Coupled Liposome (VS-1024-FY200)
CAT#: VS-1024-FY200
Anti-CD137-liposomes are innovative agents that enhance anti-tumor immune responses by delivering anti-CD137 antibodies directly to tumor sites. CD137 activation promotes T cell proliferation and survival, making it crucial for immune activation in cancer therapy. This localized delivery system improves therapeutic efficacy while minimizing systemic side effects compared to traditional systemic administration. Studies in murine B16F10 melanoma models show its potential for controlling both primary and distant tumors. Overall, anti-CD137-liposomes represent a promising strategy for cancer immunotherapy, leveraging the immune system with reduced risks.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
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More Infomation
Specifications
- Potential Clinical Applications
- This product may be utilized to induce apoptosis in B16 melanoma cells.
Product Composition
- Clone
- LOB12.3
- Antibody Type
- IgG1, kappa
- Antibody Host
- Rat
- Antibody Reactivity
- Mouse
- Antibody Description
- The LOB12.3 monoclonal antibody specifically targets mouse 4-1BB, a member of the TNF receptor superfamily also referred to as CD137. This agonistic antibody has demonstrated the ability to enhance 4-1BB signaling, leading to a delay in tumor growth in vivo, particularly when used in conjunction with immune checkpoint inhibitors.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TNFRSF9
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
- Alternative Names
- TNF Receptor Superfamily Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor, Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily, Member 9
- Full Name
- TNF Receptor Superfamily Member 9
- Gene ID
- 3604
- UniProt ID
- Q07011
- Cellular Localization
- Membrane
- Protein Refseq
- NP_001552.2
- Function
- Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
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Datasheet
MSDS
COA
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See other products for "Clone LOB12.3"
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See other products for "TNFRSF9"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (TAB-179) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (TAB-457CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G063S | Anti-TNFRSF9 immunotoxin (scFv)-Sap | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-064LC | Recombinant Anti-Human TNFRSF9 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-064LC-1 | Recombinant Anti-Human TNFRSF9 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0611CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0611CLV) | ELISA, FC | Humanized IgG1 |
| TAB-0612CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0612CLV) | ELISA, FC | Humanized IgG4 |
| TAB-0611CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0611CLV-F(E)) | ELISA, FC | Humanized Fab |
| TAB-0612CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0612CLV-F(E)) | ELISA | Humanized Fab |
| TAB-0611CLV-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0611CLV-S(P)) | ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0613CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0613CLV) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-0614CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0614CLV) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-0613CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0613CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0613CLV-S(P) | Mouse Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0613CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0614CLV-S(P) | Mouse Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0614CLV-S(P)) | ELISA | Mouse scFv |
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| MOB-2279MZ | Recombinant Mouse Anti-Human TNFRSF9 Antibody (clone 5C5 (5C5-2)), FITC-Conjugated | FC | Mouse antibody |
| HPAB-0053-FY | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-0053-FY) | ELISA | Human IgG2 |
| HPAB-0809LY | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-0809LY) | FC, FuncS | Human IgG1 |
| HPAB-0810LY | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-0810LY) | FC, FuncS | Human IgG1 |
| HPAB-0811LY | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-0811LY) | FC, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2167CQ | Rat Anti-Tnfrsf9 Recombinant Antibody (clone CBL332) | Block, WB | Rat IgG2b |
| NEUT-2168CQ | Hamster Anti-Tnfrsf9 Recombinant Antibody (clone 17B5) | FC, Block | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2169CQ | Rat Anti-Tnfrsf9 Recombinant Antibody (NEUT-2169CQ) | Neut, WB | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0253-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0253-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0254-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0254-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0255-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0255-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0256-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0256-CN-F(E)) | FC | Human Fab |
| HPAB-0257-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0257-CN-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0809LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0809LY-S(P)) | FC, FuncS | Human scfv |
| HPAB-0810LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0810LY-S(P)) | FC, FuncS | Human scfv |
| HPAB-0811LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0811LY-S(P)) | FC, FuncS | Human scfv |
| HPAB-0812LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0812LY-S(P)) | FC, FuncS | Human scfv |
| HPAB-0813LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0813LY-S(P)) | FC, FuncS | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-457CQ | Afuco™ Anti-TNFRSF9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-457CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-179 | Afuco™ Anti-TNFRSF9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-179) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY51 | Rat Anti-Tnfrsf9 Agonistic Antibody (VS-0724-XY51) | Agonistic assays | Rat IgG2a |
| VS-0724-XY52 | Rabbit Anti-TNFRSF9 Agonistic Antibody (VS-0724-XY52) | FC, Agonistic assays, CyTOF® | Rabbit IgG |
| VS-0724-XY53 | Human Anti-TNFRSF9 Agonistic Antibody (VS-0724-XY53) | ELISA, Agonistic assays | Human IgG1 |
| VS-0724-XY54 | Rabbit Anti-TNFRSF9 Agonistic Antibody (clone RbBBK4) | ELISA, FC, Agonistic assays | Rabbit IgG, kappa |
| VS-0724-XY55 | Mouse Anti-TNFRSF9 Agonistic Antibody (VS-0724-XY55) | ELISA, FC, Agonistic assays | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY76 | Mouse Anti-NHP TNFRSF9 Recombinant Antibody (VS-1024-XY76) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY224 | CytoStream™ Rat Anti-TNFRSF9 Recombinant Antibody (VS-0225-XY224) | FC | Rat IgG1, kappa |
| VS-0225-XY225 | CytoStream™ Mouse Anti-TNFRSF9 Recombinant Antibody (VS-0225-XY225) | FC | Mouse IgG1, kappa |
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| VS-0325-FY100 | Human Anti-TNFRSF9 (clone 39E3) scFv-Fc Chimera | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-0425-YC223 | Recombinant Anti-TNFRSF9 Vesicular Antibody, EV Displayed (VS-0425-YC223) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7386 | Anti-TNFRSF9 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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