Anti-TNFRSF9 (clone LOB12.3) Recombinant Antibody Coupled Liposome (VS-1024-FY200) (CAT#: VS-1024-FY200)
Anti-CD137-liposomes are innovative agents that enhance anti-tumor immune responses by delivering anti-CD137 antibodies directly to tumor sites. CD137 activation promotes T cell proliferation and survival, making it crucial for immune activation in cancer therapy. This localized delivery system improves therapeutic efficacy while minimizing systemic side effects compared to traditional systemic administration. Studies in murine B16F10 melanoma models show its potential for controlling both primary and distant tumors. Overall, anti-CD137-liposomes represent a promising strategy for cancer immunotherapy, leveraging the immune system with reduced risks.
More Infomation
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
Specifications
- Potential Clinical Applications
- This product may be utilized to induce apoptosis in B16 melanoma cells.
Product Composition
- Clone
- LOB12.3
- Antibody Type
- IgG1, kappa
- Antibody Host
- Rat
- Antibody Reactivity
- Mouse
- Antibody Description
- The LOB12.3 monoclonal antibody specifically targets mouse 4-1BB, a member of the TNF receptor superfamily also referred to as CD137. This agonistic antibody has demonstrated the ability to enhance 4-1BB signaling, leading to a delay in tumor growth in vivo, particularly when used in conjunction with immune checkpoint inhibitors.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TNFRSF9
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
- Alternative Names
- TNF Receptor Superfamily Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor, Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily, Member 9
- Full Name
- TNF Receptor Superfamily Member 9
- Gene ID
- 3604
- UniProt ID
- Q07011
- Cellular Localization
- Membrane
- Protein Refseq
- NP_001552.2
- Function
- Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (TAB-179) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (TAB-457CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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