Rat Anti-TNFRSF9 Recombinant Antibody (clone LOB12.3) (CAT#: HPAB-0670YY)
This product is a recombinant Rat antibody that recognizes (both natural and recombinant) Mouse TNFRSF9.
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FC
Figure 1 co-expression of 4-1BB and LAG-3 identifies a significant fraction of the CD8+ TIL compartment found in progressing tumors.
Representative analysis of 4-1BB and LAG-3 expression on CD8+ T cells from B16.SIY tumors and the spleen and TdLN from tumor bearing mice on day 7, 14 and 21 after s.c. tumor inoculation.
Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D., & Gajewski, T. F. (2017). The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. Journal of Experimental Medicine, 214(2), 381-400.
FC
Figure 2 co-expression of 4-1BB and LAG-3 identifies a significant fraction of the CD8+ TIL compartment found in progressing tumors.
Representative flow plots of the 4-1BB/LAG-3 populations in other tumor models. Mice were inoculated with 2 × 106 C1498.SIY, MC38.SIY, EL4. SIY, B16 Parental, MC57.SIY, or 1969.SIY s.c. and analyzed for 4-1BB and LAG-3 expression on day 14 after tumor inoculation.
Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D., & Gajewski, T. F. (2017). The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. Journal of Experimental Medicine, 214(2), 381-400.
Inhib
Figure 3 Anti-4-1BB and anti-LAG-3 acts synergistically to control tumor outgrowth and restore tIL function.
Tumor outgrowth measured in mm2. Arrows indicate on which days mice received antibody therapy.
Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D., & Gajewski, T. F. (2017). The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. Journal of Experimental Medicine, 214(2), 381-400.
Inhib
Figure 4 Anti-4-1BB and anti-LAG-3 acts synergistically to control tumor outgrowth and restore tIL function.
Composition of H-2Kb/SIY+ CD8+ TILs on day 14. Mice received antibody doses (100 µg each) on days 7, 10, 13, and 16.
Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D., & Gajewski, T. F. (2017). The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. Journal of Experimental Medicine, 214(2), 381-400.
Specifications
- Host Species
- Rat
- Type
- Rat IgG2a
- Specificity
- Mouse
- Species Reactivity
- Mouse
- Clone
- LOB12.3
- Applications
- FC, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The TNFRSF9 antibody has been reported in applications of Flow Cytometry, Inhibition.
Inhib: 100 µg.
Target
- Alternative Names
- TNF Receptor Superfamily Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor, Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily, Member 9; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
- Gene ID
- 21942
- UniProt ID
- Q8R037
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone LOB12.3"
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (Urelumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (Utomilumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G063S | Anti-TNFRSF9 immunotoxin (scFv)-Sap | Cytotoxicity assay, Function study |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-064LC | Recombinant Anti-Human TNFRSF9 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
High-mannose Glycoform
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-064LC-1 | Recombinant Anti-Human TNFRSF9 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0611CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0611CLV) | ELISA, FC | Humanized IgG1 |
| TAB-0612CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0612CLV) | ELISA, FC | Humanized IgG4 |
| TAB-0611CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0611CLV-F(E)) | ELISA, FC | Humanized Fab |
| TAB-0612CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0612CLV-F(E)) | ELISA | Humanized Fab |
| TAB-0611CLV-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0611CLV-S(P)) | ELISA, FC | Humanized scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0613CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0613CLV) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-0614CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0614CLV) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-0613CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0613CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0613CLV-S(P) | Mouse Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0613CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0614CLV-S(P) | Mouse Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0614CLV-S(P)) | ELISA | Mouse scFv |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2167CQ | Rat Anti-Tnfrsf9 Recombinant Antibody (clone CBL332) | Block, WB | Rat IgG2b |
| NEUT-2168CQ | Hamster Anti-Tnfrsf9 Recombinant Antibody (clone 17B5) | FC, Block | Hamster IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2169CQ | Rat Anti-Tnfrsf9 Recombinant Antibody (clone 6J43) | Neut, WB | Rat IgG2 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0400-YC | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-N0400-YC) | ELISA, FC, FuncS | Human IgG |
| HPAB-N0401-YC | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-N0401-YC) | ELISA, FC, FuncS | Human IgG |
| HPAB-N0402-YC | Mouse Anti-TNFRSF9 Recombinant Antibody (HPAB-N0402-YC) | FuncS | Mouse IgG |
| HPAB-N0403-YC | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-N0403-YC) | FuncS | Human IgG4 |
| HPAB-0809LY | Human Anti-TNFRSF9 Recombinant Antibody (HPAB-0809LY) | FC, FuncS | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0809LY-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0809LY-F(E)) | FC, FuncS | Human Fab |
| HPAB-0810LY-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0810LY-F(E)) | FC, FuncS | Human Fab |
| HPAB-0811LY-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0811LY-F(E)) | FC, FuncS | Human Fab |
| HPAB-0812LY-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0812LY-F(E)) | FC, FuncS | Human Fab |
| HPAB-0813LY-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0813LY-F(E)) | FC, FuncS | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-457CQ | Afuco™ Anti-TNFRSF9 ADCC Recombinant Antibody (Utomilumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-179 | Afuco™ Anti-TNFRSF9 ADCC Recombinant Antibody (Urelumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0333-YC-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-M0333-YC-S(P)) | Agonist | Humanized scFv |
| HPAB-2826LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-2826LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-2827LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-2827LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-2828LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-2828LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-0670YY-S(P) | Rat Anti-TNFRSF9 Recombinant Antibody (clone LOB12.3); scFv Fragment | ELISA | Rat scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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