Recombinant Anti-TGFBR2 Vesicular Antibody, EV Displayed (VS-0425-YC106) (CAT#: VS-0425-YC106)

• Application
• ELISA, FC, Inhib, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• TGFBR2

• Host Animal
• Human

• Antibody Isotype
• IgG2 kappa

• Species Reactivity
• Human, Rat

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Transforming growth factor beta receptor 2

• Biological Process
• Apoptosis, Differentiation, Growth regulation

• Molecular Function
• Kinase, Receptor, Serine/threonine-protein kinase, Transferase

• Cellular Localization
• Plasma membrane

• Introduction
• The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

• Alternative Names
• MFS2, TBR-ii, TBRII

• Gene ID
• 7048

• UniProt ID
• P37173

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