Recombinant Anti-TGFBR2 Vesicular Antibody, EV Displayed (VS-0425-YC106)
CAT#: VS-0425-YC106
The Recombinant Anti-TGFBR2 Vesicular Antibody, EV Displayed (VS-0425-YC106) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TGFBR2-expressed cells or tissues. The TGFBR2 is a receptor in the TGF-beta signaling pathway, with mutations linked to various syndromes and cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73537/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HSkMC, LHCN-M2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163513-TGFBR2
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TGFBR2
- Host Animal
- Human
- Antibody Isotype
- IgG2 kappa
- Species Reactivity
- Human, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Transforming growth factor beta receptor 2
- Biological Process
- Apoptosis, Differentiation, Growth regulation
- Molecular Function
- Kinase, Receptor, Serine/threonine-protein kinase, Transferase
- Cellular Localization
- Plasma membrane
- Introduction
- The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
- Alternative Names
- MFS2, TBR-ii, TBRII
- Gene ID
- 7048
- UniProt ID
- P37173
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Related Signaling Pathways
JAK-STAT Signaling Pathway
TGF-β Signaling Pathway
Related Diseases
Pancreatic Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2022CT | Recombinant Mouse anti-Human TGFBR2 Monoclonal antibody (NN0067-5G25) | FC, IHC-Fr, IHC-P, WB | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3552 | Rabbit Anti-TGFBR2 Recombinant Antibody (clone DS3552AB) | WB | Rabbit IgG |
| MOR-4762 | Rabbit Anti-TGFBR2 Recombinant Antibody (clone TH276DS) | WB, IF, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232-YC-S(P) | Human Anti-TGFBR2 Recombinant Antibody (clone TGF1); scFv Fragment | ELISA, FuncS | Humanized scFv |
| HPAB-0150-FY-S(P) | Human Anti-TGFBR2 Recombinant Antibody (clone LY3022859); scFv Fragment | ELISA | Human scFv |
| HPAB-0726-CN-S(P) | Human Anti-TGFBR2 Recombinant Antibody (clone TGF3); scFv Fragment | WB, ELISA | Human scFv |
| HPAB-N0262-YC-S(P) | Human Anti-TGFBR2 Recombinant Antibody (clone Antibody A); scFv Fragment | Block | Human scFv |
| HPAB-J0240-YC-S(P) | Human Anti-TGFBR2 Recombinant Antibody (clone TGF2); scFv Fragment | ELISA, Block | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232-YC-F(E) | Human Anti-TGFBR2 Recombinant Antibody (clone TGF1); Fab Fragment | ELISA, FuncS | Humanized Fab |
| HPAB-0150-FY-F(E) | Human Anti-TGFBR2 Recombinant Antibody (clone LY3022859); Fab Fragment | ELISA | Human Fab |
| HPAB-0726-CN-F(E) | Human Anti-TGFBR2 Recombinant Antibody (clone TGF3); Fab Fragment | WB, ELISA | Human Fab |
| HPAB-N0262-YC-F(E) | Human Anti-TGFBR2 Recombinant Antibody (clone Antibody A); Fab Fragment | Block | Human Fab |
| HPAB-J0240-YC-F(E) | Human Anti-TGFBR2 Recombinant Antibody (clone TGF2); Fab Fragment | ELISA, Block | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY52 | Human Anti-TGFBR2 (clone LY3022859) scFv-Fc Chimera | Block, ADCC (weak), ELISA | Human IgG1, scFv-Fc |
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