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    TGFBR2

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
    Protein class

    Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Hepatic stellate cells, Adipocytes, Endothelial cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (ASC diff, ASC TERT1, HSkMC, LHCN-M2, TIME)

    Interaction

    Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with DYNLT4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta. Interacts with CLU (PubMed:8555189). [Isoform 3]: Homodimer; disulfide-linked.

    Molecular function

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    More Types Infomation
    Related Signaling Pathways
    JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
    TGF-β Signaling Pathway TGF-β Signaling Pathway
    Related Diseases
    Pancreatic Cancer Pancreatic Cancer
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