Human Anti-TGFBR2 (clone LY3022859) scFv-Fc Chimera (CAT#: VS-0425-FY52)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human TGFBR2

• Species Reactivity
• Human

• Clone
• LY3022859

• Applications
• Blocking, ADCC (weak), ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Transforming Growth Factor Beta Receptor 2; Transforming Growth Factor, Beta Receptor II (70/80kDa); Transforming Growth Factor Beta Receptor II; TGF-Beta Type II Receptor; EC 2.7.11.30; TbetaR-II; TGFR-2; Transforming Growth Factor, Beta Receptor II Epsilon; Transforming Growth Factor, Beta Receptor II Alpha; Transforming Growth Factor, Beta Receptor II Delta; Transforming Growth Factor, Beta Receptor II Gamma; Transforming Growth Factor Beta Receptor Type IIC; Transforming Growth Factor, Beta Receptor II Beta; Transforming Growth Factor-Beta Receptor Type II; TGF-Beta Receptor Type IIB

• Gene ID
• 7048

• UniProt ID
• P37173

• Long Name
• Transforming Growth Factor Beta Receptor 2

• Sequence Similarities
• Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

• Cellular Localization
• Cell membrane, Membrane, Secreted

• Post Translation Modifications
• Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.

• Protein Refseq
• NP_001020018.1; NP_003233.4

• Function
• Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
  Isoform 1: Has transforming growth factor beta-activated receptor activity.
  Isoform 2: Has transforming growth factor beta-activated receptor activity.
  Isoform 3: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1.

• HPAB-0150-FY
• Human Anti-TGFBR2 Recombinant Antibody (clone LY3022859)

• HPAB-0150-FY-S(P)
• Human Anti-TGFBR2 Recombinant Antibody (clone LY3022859); scFv Fragment

• HPAB-0150-FY-F(E)
• Human Anti-TGFBR2 Recombinant Antibody (clone LY3022859); Fab Fragment

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