Afuco™ Anti-Human DKK1 ADCC Recombinant Antibody (BHQ880), ADCC Enhanced (CAT#: AFC-202CL)
Anti-DKK1 ADCC Enhanced Antibody (BHQ880) is an ADCC enhanced antibody produced by our Afuco™ platform. BHQ880 is a human neutralizing IgG1 anti-DKK1 monoclonal antibody, that is being investigated for its impact on multiple myeloma-related bone disease and as an agent with potential anti-myeloma activity. BHQ880 in combination with zoledronic acid and anti-myeloma therapy was well tolerated and demonstrated potential clinical activity in patients with relapsed or refractory multiple myeloma.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Bone-related Diseases; Multiple Myeloma
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
- Alternative Names
- DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1
- Gene ID
- 22943
- UniProt ID
- I1W660
Related Resources
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1882z | Mouse Anti-DKK1 Recombinant Antibody (clone 25A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0278-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0278-YC) | ELISA, Block, FuncS | Human IgG |
| HPAB-0279-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0279-YC) | Block, FuncS | Human IgG |
| HPAB-670-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-670-FY) | ELISA | Human IgG, λ |
| ZG-0479F | Mouse Anti-DKK1 Recombinant Antibody (ZG-0479F) | WB, ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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