Anti-CD70 (clone 2F2)-vc-MMAF ADC
CAT#: ADC-116CL
This ADC product is composed of an anti-CD70 antibody (clone 2F2) conjugated via vc linker to MMAF(2F2-val-cit-MMAF). It has demonstrated a response in cancer and immune disorders treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
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Specifications
- Antibody Overview
- Anti-CD70 Monoclonal Antibody, 2F2
- Clone
- 2F2
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Gene ID
- 970
- UniProt ID
- P32970
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Datasheet
MSDS
COA
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See other products for "Clone 2F2"
- CAT
- Product Name
See other products for "CD70"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1584z | Mouse Anti-CD70 Recombinant Antibody (clone 24B8) | FC, IF, IHC, IP | Mouse IgG1, κ |
| HPAB-0095-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) | ELISA, FC, ADCC, FuncS | Human IgG |
| HPAB-0096-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| HPAB-0097-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0097-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| HPAB-0099-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0099-LSX) | ELISA, FC, Block | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H76 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-335LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-335LC-F(E)) | ELISA | Humanized Fab |
| TAB-342LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-342LC-F(E)) | FC | Humanized Fab |
| TAB-343LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-343LC-F(E)) | FC | Humanized Fab |
| TAB-344LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-344LC-F(E)) | FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VLVH) | FC, ELISA | Human antibody |
| TAB-337LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VHVL) | FC, ELISA | Human antibody |
| TAB-338LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-5-VH) | FC, ELISA | Human antibody |
| TAB-339LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VH-5-VL) | FC, ELISA | Human antibody |
| TAB-340LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-8-VH) | FC, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0095-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0096-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0096-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0097-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0097-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0098-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0098-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0099-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0099-LSX-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H76) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP584-YC-F(E) | Mouse Anti-CD70 Recombinant Antibody (clone m1F6); Fab Fragment | FC, ADCC, CDC, FuncS | Mouse Fab |
| HPAB-AP585-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone c1F6); Fab Fragment | FC, ADCC, CDC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-AP586-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
| HPAB-AP587-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
| HPAB-AP588-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC123 | Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced | ELISA, Inhib, ADCC, ADCP, CDC | Antibody hexamer |
| VS-0924-YC124 | Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced | FC, ADCC, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY69 | CytoStream™ Rat Anti-CD70 Recombinant Antibody (clone FR70) | FC, Block, IF, Inhib | Rat IgG2b, kappa |
| VS-0225-XY70 | CytoStream™ Mouse Anti-CD70 Recombinant Antibody (clone Ki-24) | FC | Mouse IgG3, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY72 | Human Anti-CD70 (clone 2H5) scFv-Fc Chimera | FC, ELISA, IHC, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC77 | Recombinant Anti-CD70 Vesicular Antibody, EV Displayed (VS-0425-YC77) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1215 | Anti-CD70 Immunohistochemistry Kit | IHC |
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