Afuco™ Anti-Human AXL ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-056CL
Anti-AXL ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Anti-AXL antibodies can bind to a specific region in Anexelekto (AXL) and are useful as agents for decreasing the AXL expression level, antitumor agents, and diagnostic agents for cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human thyroid gland
Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg
Normal Tissue
Figure 3 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
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Great For Signal Assays
We used this antibody to detect AXL in signal transduction assays and found it to be highly sensitive. The ADCC enhancement is a notable advantage for our cytotoxicity studies.
Minimal Cross-Reactivity
We've tested this antibody across various AXL-expressing and non-expressing cell lines. The specificity is impressive with minimal cross-reactivity, making it reliable for our targeted studies.
Effective in Blocking AXL
We observed effective neutralization of AXL receptor signaling, which provided us valuable insights into AXL's role in cancer metastasis.
Q&As
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What is the primary target of the Afuco™ Anti-Human AXL ADCC Recombinant Antibody?
A: The primary target of this antibody is the AXL receptor tyrosine kinase, which is a member of the TAM receptor family.
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What is the significance of ADCC enhancement in this antibody?
A: ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity) enhancement increases the antibody's ability to recruit immune cells to target and kill the AXL-expressing cells.
-
What type of research applications can this antibody be used for?
A: This antibody is commonly used in cancer research, specifically in understanding the role of AXL in tumor progression and metastasis.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0189CL-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (TAB-0189CL-S(P)) | WB, FuncS, ELISA, FC | Human scFv |
| TAB-1090CL-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (TAB-1090CL-S(P)) | ELISA, FuncS | Mouse scFv |
| TAB-1091CL-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (TAB-1091CL-S(P)) | ELISA, FuncS | Mouse scFv |
| TAB-1092CL-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (TAB-1092CL-S(P)) | ELISA, FuncS | Mouse scFv |
| TAB-1071CLV-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (TAB-1071CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3970 | Hi-Affi™ Rabbit Anti-AXL Recombinant Antibody (clone SI30DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0600-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0600-CN-F(E)) | ELISA, FC, IHC, Block | Human Fab |
| HPAB-0601-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0601-CN-F(E)) | ELISA, FC, IHC, Block | Human Fab |
| HPAB-0603-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0603-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
| HPAB-625-FY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-625-FY-F(E)) | WB, Inhib | Mouse Fab |
| HPAB-626-FY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-626-FY-F(E)) | Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0416-YC-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-M0416-YC-S(P)) | ELISA | Human scFv |
| HPAB-1850LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1850LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| HPAB-1851LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1851LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| HPAB-1852LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1852LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| HPAB-1853LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1853LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1850LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1850LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
| HPAB-1851LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1851LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
| HPAB-1852LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1852LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
| HPAB-1853LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1853LY) | FC, SPR, IHC, WB, ELISA, IA, FC, IP | Mouse IgG |
| HPAB-1854LY | Mouse Anti-AXL Recombinant Antibody (HPAB-1854LY) | ELISA, IA, FC, IHC, WB, IP | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0425-YC363 | Recombinant Anti-AXL Vesicular Antibody, EV Displayed (VS-0425-YC363) | ELISA, FC, Inhib, Cell-uptake |
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