Anti-Human AXL Recombinant Antibody scFv Fragment (hzl613F12-24 DAR2) (CAT#: TAB-0139CL-S(P))
The humanized Axl antibody-drug conjugate consisting of a pyrrolobenzodiazepine dimer target the protein Axl, of which the overexpression is related with poor prognosis and increased invasiveness of a variety of human cancers such as breast, colon, esophageal carcinoma, osteosarcoma and so on.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg
Figure 2 IHC staining of human thyroid gland
(Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg
(Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg
Figure 3 Skeletal muscle
(Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg
(Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, U-251 MG)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL
Specifications
- Host Species
- Human
- Type
- Humanized Antibody
- Specificity
- Human
- Clone
- hzl613F12-24 DAR2
- Related Disease
- Breast, colon, esophageal carcinoma, osteosarcoma, renal cancer
Target
- Alternative Names
- AXL; AXL receptor tyrosine kinase; ARK; UFO; JTK11; Tyro7
- Gene ID
- 558
- UniProt ID
- P30530
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0335CL | Anti-Human AXL Recombinant Antibody (Ax225 (was demonstrated to recognize FND1 of AXL)) | WB, FuncS, ELISA | |
| TAB-0336CL | Anti-Human AXL Recombinant Antibody | WB, FuncS, ELISA | |
| TAB-1087CL | Human Anti-AXL Recombinant Antibody (TAB-1087CL) | ADCC | Chimeric (mouse/human) IgG1, κ |
| TAB-1088CL | Human Anti-AXL Recombinant Antibody (TAB-1088CL) | ADCC | Chimeric (mouse/human) IgG1, κ |
| TAB-1089CL | Human Anti-AXL Recombinant Antibody (TAB-1089CL) | ELISA, FuncS | Chimeric (mouse/human) IgG1, κ |
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