Anti-Human CCL2 Recombinant Antibody (MC32) (CAT#: TAB-0750CL)

Recombinant monoclonal antibody MC32 is a human monoclonal antibody that specifically binds to human MCP-1 and can be potentially used in the treatment of chronic autoimmune disease.


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ELISA

Figure 1 MCP-1-specific scFv clones.

Figure 1 MCP-1-specific scFv clones.

ELISA plates were coated isolates from the k-library, with 80 ng/well of MCP-1 and various unrelated proteins for 12 h.

Yoshinaga, K., Matsumoto, M., Torikai, M., Sugyo, K., Kuroki, S., Nogami, K., ... & Sugimura, K. (2008). Ig L-chain shuffling for affinity maturation of phage library-derived human anti-human MCP-1 antibody blocking its chemotactic activity. Journal of biochemistry, 143(5), 593-601.

Block

Figure 2 Biochemical characterization of scFvs.

Figure 2 Biochemical characterization of scFvs.

Immunoblotting was performed blotting analysis: the periplasmic extract (MC8, MC32, MC62,with HRP-conjugated anti-E-tag mAb.

Yoshinaga, K., Matsumoto, M., Torikai, M., Sugyo, K., Kuroki, S., Nogami, K., ... & Sugimura, K. (2008). Ig L-chain shuffling for affinity maturation of phage library-derived human anti-human MCP-1 antibody blocking its chemotactic activity. Journal of biochemistry, 143(5), 593-601.

Inhib

Figure 3 Inhibitory activity of MC32 on the MCP-1-induced chemotaxis of THP-1 cells.

Figure 3 Inhibitory activity of MC32 on the MCP-1-induced chemotaxis of THP-1 cells.

Microscopic observation: cells were stained with Wright–Giemsa stain (Diff-Qick).

Yoshinaga, K., Matsumoto, M., Torikai, M., Sugyo, K., Kuroki, S., Nogami, K., ... & Sugimura, K. (2008). Ig L-chain shuffling for affinity maturation of phage library-derived human anti-human MCP-1 antibody blocking its chemotactic activity. Journal of biochemistry, 143(5), 593-601.


Specifications

  • Host Species
  • Human
  • Derivation
  • Human phage display library
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • MC32
  • Applications
  • ELISA, Block, Inhib
  • Related Disease
  • Chronic autoimmune disease

Applications

  • Application Notes
  • The CCL2 antibody has been reported in applications of Blocking, Enzyme-linked Immunosorbent Assay, Inhibition.

Target

  • Alternative Names
  • CCL2; chemokine (C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; C-C motif chemokine 2; small-inducible cytokine A2; monocyte secretory protein JE; monocyte chemotactic protein 1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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NEUT-151CQ Mouse Anti-CCL2 Recombinant Antibody (clone MNA1) WB, Neut, ELISA, FC, IA, IF, IHC, IHC-Fr, IHC-P, IP Mouse IgG1

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-117 Afuco™ Anti-CCL2 ADCC Recombinant Antibody (Carlumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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