Afuco™ Anti-CCL2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-117)
CAT#: AFC-TAB-117
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to MCP-1. It is a humanized monoclonal antibody against human 1-40 and 1-42 Beta amyloid, which is being investigated as a treatment of Alzheimer's disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19163/1742_B4_8_cr580492c5c7769_selected.jpg
Subcellular Location
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in dot like pattern in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19163/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human appendix
Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13676/29298_A_2_2_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19163/182_D1_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13676/29298_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13676/29298_A_8_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13676/29298_A_7_5.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (BJ hTERT+, HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000108691-CCL2
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Specifications
- Immunogen
- Recombinant hMCAF/MCP-1 (human Macrophage/Monocyte chemotactic protein-1)
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut
- Conjugate
- Unconjugated
- Generic Name
- Carlumab
- Related Disease
- Pulmonary Fibrosis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Carlumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Carlumab.
Related Diseases
Rheumatoid Arthritis
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Carlumab"
Anti-Human MCP-1 Recombinant Antibody (Carlumab)Recombinant monoclonal antibody to MCP-1.
DrugMonitor™ Anti-Carlumab Antibody (VS-1224-YC255)Carlumab has been studied in trials for cancer and prostate cancer treatment. The DrugMonitor™ Anti-Carlumab Antibody (VS-1224-YC255) is an anti-drug antibody (ADA) against Carlumab. This drug-based antibody is raised in mice immunized with the Carlumab. The anti-Carlumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Carlumab in samples.
See other products for "CCL2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1273z | Mouse Anti-CCL2 Recombinant Antibody (clone 15A10) | ELISA, WB | Mouse IgG1 |
| PABL-421 | Human Anti-CCL2 Recombinant Antibody (clone CNTO 888) | Inhib, IB, FuncS | Human IgG |
| ZG-0273C | Mouse Anti-CCL2 Recombinant Antibody (ZG-0273C) | WB, ELISA | Mouse IgG |
| VS-0923-FY32 | Recombinant Mouse Anti-CCL2 Antibody (VS-0923-FY32) | ELISA, WB | Mouse IgG2b |
| VS3-WK1674 | Recombinant Mouse Anti-CCL2 Capture Antibody (clone 4A2) | ELISA | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-038 | Recombinant Anti-Human CCL2 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-418 | Human Anti-CCL2 Recombinant Antibody (clone CNTO 888); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-1658-FY-S(P) | Mouse Anti-CCL2 Recombinant Antibody (clone C775); Fab Fragment | ELISA | Mouse Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-418 | Human Anti-CCL2 Recombinant Antibody (clone CNTO 888); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-1658-FY-F(E) | Mouse Anti-CCL2 Recombinant Antibody (clone C775); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0748CL | Anti-Human CCL2 Recombinant Antibody (1.1.1) | ELISA | Human antibody |
| TAB-0749CL | Anti-Human CCL2 Recombinant Antibody (1.10.1) | ELISA | Human antibody |
| TAB-0750CL | Anti-Human CCL2 Recombinant Antibody (MC32) | ELISA, Block, Inhib | Human antibody |
| TAB-0751CL | Anti-Human CCL2 Recombinant Antibody (MC8) | ELISA | Human antibody |
| TAB-0752CL | Anti-Human CCL2 Recombinant Antibody (MC15) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-147CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL605) | WB, ELISA(Cap), ICC, Neut | Mouse IgG1 |
| NEUT-148CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL221) | ELISA, WB, Neut | Mouse IgG1, κ |
| NEUT-149CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL436) | WB, Neut | Mouse IgG1 |
| NEUT-150CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL728) | WB, ELISA(Cap), Neut | Mouse IgG2b |
| NEUT-151CQ | Mouse Anti-CCL2 Recombinant Antibody (clone MNA1) | WB, Neut, ELISA, FC, IA, IF, IHC, IHC-Fr, IHC-P, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0504 | Hi-Affi™ Rabbit Anti-CCL2 Recombinant Antibody (clone DS504AB) | WB, IF | Rabbit IgG |
| MOR-4543 | Hi-Affi™ Rabbit Anti-CCL2 Recombinant Antibody (clone TH52DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY44 | AbPlus™ Anti-CCL2 Magnetic Beads (MNA1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY319 | Mouse Anti-NHP CCL2 Recombinant Antibody (clone 2D8) | WB, IHC, IF, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY9 | CytoStream™ Armenian Hamster Anti-CCL2 Recombinant Antibody (clone 2H5) | ELISA, FC, Neut | Armenian Hamster IgG1, kappa |
| VS-0225-XY10 | CytoStream™ Mouse Anti-CCL2 Recombinant Antibody (clone 5D3-F7) | FC | Mouse IgG1, kappa |
| VS13-YC144 | CytoStream™ Rabbit Anti-CCL2 Polyclonal Antibody (VS13-YC144) | WB, ELISA, IHC-P, IHC-Fr, FC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY151 | Mouse Anti-CCL2 scFv-Fc Chimera (VS-0425-FY151) | ELISA, IHC, WB | Mouse IgG2b, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1055 | Anti-CCL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1056 | Anti-Mouse CCL2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC45 | Recombinant Anti-CCL2 Eliminating Antibody, pH-Sensitive (VS-0625-YC45) | Antigen-Sweeping In Vivo. | Human IgG1 kappa |
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