Anti-Human MCP-1 Recombinant Antibody (Carlumab) (CAT#: TAB-117)
Recombinant monoclonal antibody to MCP-1.
Specific Inquiry
PK
Figure 1 Pharmacokinetics result.
(A) Goodness‐of‐fit plots of carlumab, free CCL2, and carlumab–CCL2 complex. (B) Comparison of predicted and observed PK/PD profiles of carlumab, free CCL2, and carlumab–CCL2 complex for the 15 mg/kg dose level.
Fetterly, G. J., Aras, U., Meholick, P. D., Takimoto, C., Seetharam, S., McIntosh, T.,... & Zhou, H. (2013). Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data. The Journal of Clinical Pharmacology, 53(10), 1020-1027.
PD
Figure 2 Pharmacodynamics result.
a) Total CC-chemokine ligand (CCL)2 levels over time; b) free CCL2 levels over time.
Raghu, G., Martinez, F. J., Brown, K. K., Costabel, U., Cottin, V., Wells, A. U.,... & Mack, M. (2015). CC-chemokine ligand 2 inhibition in idiopathic pulmonary fibrosis: a phase 2 trial of carlumab. European Respiratory Journal, 46(6), 1740-1750.
Specifications
- Immunogen
- Recombinant hMCAF/MCP-1 (human Macrophage/Monocyte chemotactic protein-1)
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC, PK, PD
- CAS
- 1174395-19-7
- Generic Name
- Carlumab
- MW
- 144.88 kDa
- Related Disease
- Pulmonary Fibrosis
Product Property
- Purity
- >95.0% as determined by analysis by RP-HPLC.
- Storage
- At -20°C for one year.
Applications
- Application Notes
- The CCL2 antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, PK, PD.
Target
- Alternative Names
- Carlumab;1174395-19-7;CNTO 888;CCL2;chemokine (C-C motif) ligand 2;SCYA2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je);C-C motif chemokine 2;GDCF 2;HC11;MCAF;MCP 1;MCP1;MGC9434;monocyte chemoattractant protein 1
- Gene ID
- 6347
- UniProt ID
- P13500
Related Resources
Please refer to Carlumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Carlumab.
Rheumatoid Arthritis
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Carlumab"
Afuco™ Anti-CCL2 ADCC Recombinant Antibody (Carlumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to MCP-1. Crenezumab is a humanized monoclonal antibody against human 1-40 and 1-42 Beta amyloid, which is being investigated as a treatment of Alzheimer's disease.
See other products for "CCL2"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-038 | Recombinant Anti-Human CCL2 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-421 | Human Anti-CCL2 Recombinant Antibody (clone CNTO 888) | Inhib, IB, FuncS | Human IgG |
| HPAB-1658-FY | Mouse Anti-CCL2 Recombinant Antibody (clone C775) | ELISA | Mouse IgG1, κ |
| ZG-0153U | Mouse Anti-CCL2 Recombinant Antibody (clone 3D2E5) | ELISA, IHC | Mouse IgG2b |
| VS3-WK25 | Mouse Anti-CCL2 Recombinant Antibody (clone E11-D8) | WB, ELISA | Mouse IgG1 |
| VS-0923-FY32 | Recombinant Mouse Anti-CCL2 Antibody (VS-0923-FY32) | ELISA, WB | Mouse IgG2b |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-418 | Human Anti-CCL2 Recombinant Antibody (clone CNTO 888); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-1658-FY-S(P) | Mouse Anti-CCL2 Recombinant Antibody (clone C775); Fab Fragment | ELISA | Mouse Fab, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-418 | Human Anti-CCL2 Recombinant Antibody (clone CNTO 888); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-1658-FY-F(E) | Mouse Anti-CCL2 Recombinant Antibody (clone C775); scFv Fragment | ELISA | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0744CL | Anti-Human CCL2 Recombinant Antibody (AAV293) | ELISA | |
| TAB-0745CL | Anti-Human CCL2 Recombinant Antibody (AAV294) | ELISA | |
| TAB-0754CL | Mouse Anti-CCL2 Recombinant Antibody (TAB-0754CL) | ELISA, SPR, DB, IHC | Mouse IgG1 |
| TAB-0755CL | Mouse Anti-CCL2 Recombinant Antibody (TAB-0755CL) | SPR, DB, IHC | Mouse IgG1 |
| TAB-0756CL | Mouse Anti-CCL2 Recombinant Antibody (TAB-0756CL) | ELISA, SPR, DB, IHC | Mouse IgG2b |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0748CL-S(P) | Anti-Human CCL2 Recombinant Antibody scFv Fragment (1.1.1) | ELISA | Human antibody |
| TAB-0749CL-S(P) | Anti-Human CCL2 Recombinant Antibody scFv Fragment (1.10.1) | ELISA | Human antibody |
| TAB-0750CL-S(P) | Anti-Human CCL2 Recombinant Antibody scFv Fragment (MC32) | ELISA | Human antibody |
| TAB-0748CL-F(E) | Anti-Human CCL2 Recombinant Antibody Fab Fragment (1.1.1) | ELISA | Human antibody |
| TAB-0749CL-F(E) | Anti-Human CCL2 Recombinant Antibody Fab Fragment (1.10.1) | ELISA | Human antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-147CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL605) | WB, ELISA(Cap), ICC, Neut | Mouse IgG1 |
| NEUT-148CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL221) | ELISA, WB, Neut | Mouse IgG1, κ |
| NEUT-149CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL436) | WB, Neut | Mouse IgG1 |
| NEUT-150CQ | Mouse Anti-CCL2 Recombinant Antibody (clone CBL728) | WB, ELISA(Cap), Neut | Mouse IgG2b |
| NEUT-151CQ | Mouse Anti-CCL2 Recombinant Antibody (clone MNA1) | WB, Neut, ELISA, FC, IA, IF, IHC, IHC-Fr, IHC-P, IP | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0504 | Hi-Affi™ Rabbit Anti-CCL2 Recombinant Antibody (clone DS504AB) | WB, IF | Rabbit IgG |
| MOR-4543 | Hi-Affi™ Rabbit Anti-CCL2 Recombinant Antibody (clone TH52DS) | WB | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-117 | Afuco™ Anti-CCL2 ADCC Recombinant Antibody (Carlumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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