Anti-Human CD44 Recombinant Antibody (chPTA-4621) (CAT#: TAB-235LC)

Recombinant monoclonal antibody to CD44. chPTA-4621 is a chimeric antibody (mouse/human) that can be potentially used in the treatment of head and neck squamous cell carcinoma (HNSCC).


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  • Gene Expression
  • Datasheet
  • MSDS
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FuncS

Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.

Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.

Data points represent the mean +/- SEM.

FuncS

Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.

Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.

The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.

Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.

The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.

Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.

FuncS

Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.

Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.


Specifications

  • Host Species
  • Human
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • Chimeric antibody (mouse/human)
  • Specificity
  • Human
  • Clone
  • chPTA-4621
  • Applications
  • FuncS
  • Related Disease
  • Head and neck squamous cell carcinoma (HNSCC)

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay.

Target

  • Alternative Names
  • IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone chPTA-4621"

See other products for "CD44"

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0101MZ Chicken Anti-CD44 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-378CQ Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1) FC, IF, Inhib, IP, WB Rat IgG2b
NEUT-381CQ Human Anti-CD44 Recombinant Antibody (clone Hermes-3) ELISA, FC, IF, IHC, IP, Neut, WB Human IgG1, κ
NEUT-382CQ Rat Anti-CD44 Recombinant Antibody (clone IM7) Block Rat IgG2b
NEUT-383CQ Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC Block, FC, IP, WB, FuncS Rat IgG1, κ
NEUT-384CQ Rat Anti-CD44 Recombinant Antibody (clone KM81) IF, IHC-P, FC, Block Rat IgG2a

Neutralizing Antibody

CAT Product Name Application Type
NEUT-379CQ Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC Mouse IgG2a
NEUT-380CQ Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) WB, Neut, ELISA, FC, IF, IHC, IP Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0563 Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB) FC, IF, IHC-Fr, IHC-P, WB Rabbit IgG
MOR-4548 Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS) IF, ICC, FC Rabbit IgG

Recombinant Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-727 Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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