Anti-CD44 Recombinant Antibody (Bivatuzumab)

Name: Anti-CD44 Recombinant Antibody (Bivatuzumab)
SKU: TAB-727
Rating: 5 (1 reviews)

CAT#: TAB-727

Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. Bivatuzumab is a humanized monoclonal antibody against CD44 v6. It has been chemically linked to various radioisotopes for use in radiotherapy for, e.g. inoperable recurrent or metastatic head and neck cancer. It has also been linked to a cytotoxic drug mertansine to form bivatuzumab mertansine.

Published Data Gene Expression

ELISA

Figure 2 Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA.

Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A) or by 186Re radioactivity measurement in serum (B). Individual data points are depicted after administration of 50 mg of BIWA 4 labeled with 31.9–108.2 mCi of 186Re to 20 HNSCC patients.

Börjesson, P. K., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A., Van Schie, M. H.,... & Van Dongen, G. A. (2003). Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clinical Cancer Research, 9(10), 3961s-3972s.

ELISA

Figure 3 Blood clearance curves of 186Re-BIWA 4 for patients who received the conjugate twice.

Blood clearance was assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A–C) or by 186Re activity measurement in serum (D–F), after the first (▵) and second (○) administration of 186Re-BIWA 4 to patients 11 (A and D), 12 (B and E), and 14 (C and F).

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Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/203_H10_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/112/if_selected.jpg

Subcellular Location Figure 3 IHC staining of human vagina

Immunohistochemical staining of human vagina shows strong cytoplasmic positivity in squamous epithelial cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/5_B_2_2_selected.jpg

Normal Tissue Figure 4 Colon

Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Goblet cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_9_3.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (cell body)
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_8_5.jpg

Normal Tissue Figure 6 Skin

Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: High
Intensity: Strong
Quantity:>75%
Fibrohistiocytic cells
Staining: High
Intensity: Strong
Langerhans cells
Staining: High
Intensity: Strong
Quantity:>75%
Lymphocytes
Staining: High
Intensity: Strong
Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_B_7_1.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026508-CD44

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ

CAS
214599-60-1

Generic Name
bivatuzumab

Related Disease
Squamous cancers

Product Property

Purity
Purity >95% by SDS-PAGE.

Storage
At -20°C for one year.

Applications

Application Notes
The CD44 antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ.

Target

Alternative Names
bivatuzumab;214599-60-1;BIWA 4;CD44;CD44 molecule (Indian blood group);CD44 antigen (homing function and Indian blood group system) , MDU2, MDU3, MIC4;CD44 antigen;CD44R;chondroitin sulfate proteoglycan 8;CSPG8;HCELL;hematopoietic cell E and L selectin li

Gene ID
960

UniProt ID
P16070

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(Creative Biolabs Cat# TAB-727, RRID: AB_3111994)

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Biosimilar Overview

Please refer to Bivatuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Bivatuzumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-727.pdf

MSDS

MSDS - TAB-727.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Bivatuzumab"

Afuco™ Anti-CD44 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-727)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. It is a humanized monoclonal antibody against CD44 v6.

DrugMonitor™ Anti-Bivatuzumab Antibody (VS-1224-YC205)
Bivatuzumab (formerly BIWA 4) is a humanized monoclonal antibody against CD44 v6. The DrugMonitor™ Anti-Bivatuzumab Antibody (VS-1224-YC205) is an anti-drug antibody (ADA) against Bivatuzumab. This drug-based antibody is raised in mice immunized with the Bivatuzumab. The anti-Bivatuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Bivatuzumab in samples.

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TAB-231LC-S(P)	Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-231LC-S(P))	ELISA	Mouse scFv
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TAB-235LC-S(P)	Anti-Human CD44 Recombinant Antibody scFv Fragment (chPTA-4621)	FC	Chimeric antibody (mouse/human)
TAB-231LC-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-231LC-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-232LC-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-232LC-F(E))	ELISA	Chimeric (mouse/human) Fab

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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
HPAB-0047-YJ-S(P)	Mouse Anti-CD44 Recombinant Antibody (clone HI44a); scFv Fragment	WB, IF, FC	Mouse scFv
HPAB-0746-FY-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0746-FY-F(E))	ELISA	Human Fab
HPAB-0747-FY-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0747-FY-F(E))	ELISA	Human Fab
HPAB-0563-WJ-S(P)	Human Anti-CD44 Recombinant Antibody (clone 1A9); scFv Fragment	ELISA, FC	Human scFv
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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