Anti-CD44 Recombinant Antibody (Bivatuzumab)

Name: Anti-CD44 Recombinant Antibody (Bivatuzumab)
SKU: TAB-727
Rating: 5 (1 reviews)

CAT#: TAB-727

Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. Bivatuzumab is a humanized monoclonal antibody against CD44 v6. It has been chemically linked to various radioisotopes for use in radiotherapy for, e.g. inoperable recurrent or metastatic head and neck cancer. It has also been linked to a cytotoxic drug mertansine to form bivatuzumab mertansine.

Published Data Gene Expression

ELISA

Figure 2 Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA.

Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A) or by 186Re radioactivity measurement in serum (B). Individual data points are depicted after administration of 50 mg of BIWA 4 labeled with 31.9–108.2 mCi of 186Re to 20 HNSCC patients.

Börjesson, P. K., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A., Van Schie, M. H.,... & Van Dongen, G. A. (2003). Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clinical Cancer Research, 9(10), 3961s-3972s.

ELISA

Figure 3 Blood clearance curves of 186Re-BIWA 4 for patients who received the conjugate twice.

Blood clearance was assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A–C) or by 186Re activity measurement in serum (D–F), after the first (▵) and second (○) administration of 186Re-BIWA 4 to patients 11 (A and D), 12 (B and E), and 14 (C and F).

❮

❯

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/203_H10_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/112/if_selected.jpg

Subcellular Location Figure 3 IHC staining of human vagina

Immunohistochemical staining of human vagina shows strong cytoplasmic positivity in squamous epithelial cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/5_B_2_2_selected.jpg

Normal Tissue Figure 4 Colon

Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Goblet cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_9_3.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (cell body)
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_8_5.jpg

Normal Tissue Figure 6 Skin

Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: High
Intensity: Strong
Quantity:>75%
Fibrohistiocytic cells
Staining: High
Intensity: Strong
Langerhans cells
Staining: High
Intensity: Strong
Quantity:>75%
Lymphocytes
Staining: High
Intensity: Strong
Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_B_7_1.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026508-CD44

❮

❯

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ

CAS
214599-60-1

Generic Name
bivatuzumab

Related Disease
Squamous cancers

Product Property

Purity
Purity >95% by SDS-PAGE.

Storage
At -20°C for one year.

Applications

Application Notes
The CD44 antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ.

Target

Alternative Names
bivatuzumab;214599-60-1;BIWA 4;CD44;CD44 molecule (Indian blood group);CD44 antigen (homing function and Indian blood group system) , MDU2, MDU3, MIC4;CD44 antigen;CD44R;chondroitin sulfate proteoglycan 8;CSPG8;HCELL;hematopoietic cell E and L selectin li

Gene ID
960

UniProt ID
P16070

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for TAB-727. Click the button above to contact us or submit your feedback about this product.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-727, RRID: AB_3111994)

Copy citation

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Biosimilar Overview

Please refer to Bivatuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Bivatuzumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-727.pdf

MSDS

MSDS - TAB-727.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Bivatuzumab"

Afuco™ Anti-CD44 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-727)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. It is a humanized monoclonal antibody against CD44 v6.

DrugMonitor™ Anti-Bivatuzumab Antibody (VS-1224-YC205)
Bivatuzumab (formerly BIWA 4) is a humanized monoclonal antibody against CD44 v6. The DrugMonitor™ Anti-Bivatuzumab Antibody (VS-1224-YC205) is an anti-drug antibody (ADA) against Bivatuzumab. This drug-based antibody is raised in mice immunized with the Bivatuzumab. The anti-Bivatuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Bivatuzumab in samples.

See other products for "CD44"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
DrMAB-991	Mouse Anti-CD44 Recombinant Antibody (clone BU52)	IHC, WB, IP, Inhib, Stim	Mouse IgG1 F(ab')2, κ
FAMAB-0019-CN-F(E)	Mouse Anti-CD44 Recombinant Antibody (clone AV6); Fab Fragment	FC	Mouse Fab
HPAB-1055-FY-S(P)	Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (HPAB-1055-FY-S(P))	IHC, Inhib, FC	Mouse scFv
HPAB-1056-FY-S(P)	Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (HPAB-1056-FY-S(P))	IHC, Inhib, FC	Mouse scFv
HPAB-0443-YJ-F(E)	Human Anti-CD44 Recombinant Antibody (clone CA14); Fab Fragment	ELISA, FuncS	Human Fab

CAT	Product Name	Application	Type
TAB-236LC	Anti-Human CD44 Recombinant Antibody (huPTA-4621)	FuncS	Humanized antibody
TAB-236LC-S(P)	Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621)	FC	Humanized antibody
TAB-236LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621)	FC	Humanized antibody

CAT	Product Name	Application
TAB-237LC	Anti-Human CD44 Recombinant Antibody (LGadh01-01)	FuncS
TAB-237LC-S(P)	Anti-Human CD44 Recombinant Antibody scFv Fragment (LGadh01-01)	ELISA
TAB-238LC-S(P)	Anti-Human CD44 Recombinant Antibody scFv Fragment (LGadh01-02)	ELISA
TAB-237LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (LGadh01-01)	ELISA
TAB-238LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (LGadh01-02)	ELISA

CAT	Product Name	Application	Type
TAB-231LC-S(P)	Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-231LC-S(P))	ELISA	Mouse scFv
TAB-232LC-S(P)	Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-232LC-S(P))	ELISA	Mouse scFv
TAB-231LC-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-231LC-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-232LC-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-232LC-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-235LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (chPTA-4621)	FC	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-226LC-F(E)	Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-226LC-F(E))	WB, ELISA	Human Fab
TAB-227LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (1A9.A6.B9)	FC, ELISA	Human antibody
TAB-228LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (2D1.A3.D12)	FC, ELISA	Human antibody
TAB-229LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (14G9.B8.B4)	FC, ELISA	Human antibody
TAB-230LC-F(E)	Anti-Human CD44 Recombinant Antibody Fab Fragment (10C8.2.3)	FC, ELISA	Human antibody

CAT	Product Name	Application	Type
BRD-0101MZ	Chicken Anti-CD44 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-378CQ	Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1)	FC, IF, Inhib, IP, WB	Rat IgG2b
NEUT-381CQ	Human Anti-CD44 Recombinant Antibody (clone Hermes-3)	ELISA, FC, IF, IHC, IP, Neut, WB	Human IgG1, κ
NEUT-382CQ	Rat Anti-CD44 Recombinant Antibody (clone IM7)	Block	Rat IgG2b
NEUT-383CQ	Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC	Block, FC, IP, WB, FuncS	Rat IgG1, κ
NEUT-384CQ	Rat Anti-CD44 Recombinant Antibody (clone KM81)	IF, IHC-P, FC, Block	Rat IgG2a

CAT	Product Name	Application	Type
NEUT-379CQ	Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2)	WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC	Mouse IgG2a
NEUT-380CQ	Rat Anti-CD44 Recombinant Antibody (clone Hermes-1)	WB, Neut, ELISA, FC, IF, IHC, IP	Rat IgG2a

CAT	Product Name	Application	Type
MOR-0563	Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB)	FC, IF, IHC-Fr, IHC-P, WB	Rabbit IgG
MOR-4548	Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS)	IF, ICC, FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0054-YC-S(P)	Mouse Anti-CD44 Recombinant Antibody (clone mH460-16-2); scFv Fragment	ELISA, FC, IHC	Mouse scFv
HPAB-0055-YC-S(P)	Human Anti-CD44 Recombinant Antibody (clone chH460-16-2); scFv Fragment	ELISA, FC, IHC	Mouse scFv
HPAB-N0328-YC-S(P)	Rat Anti-CD44 Recombinant Antibody (clone 9A4); scFv Fragment	WB, ELISA, IHC-P, IHC-Fr	Rat scFv
HPAB-1055-FY-F(E)	Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1055-FY-F(E))	IHC, Inhib, FC	Mouse Fab
HPAB-1056-FY-F(E)	Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1056-FY-F(E))	IHC, Inhib, FC	Mouse Fab

CAT	Product Name	Application	Type
MRO-0307-CN	Mouse Anti-CD44 Recombinant Antibody (clone A7-1)	WB, IHC, FC	Mouse IgM

CAT	Product Name	Application	Type
AFC-TAB-727	Afuco™ Anti-CD44 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-727)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS1-YJ29	Mouse Anti-CD44 Recombinant Antibody (clone 156-3C11)	ICC, IF, IHC-P, FC	Mouse IgG2a
VS3-XY343	Mouse Anti-CD44 Recombinant Antibody, FITC (clone 4AP2A1)	FC, IHC, IP, IF	Mouse IgG2a
VS3-XY344	Mouse Anti-CD44 Recombinant Antibody, PE (clone 4AP2A1)	FC, IHC, IP, IF	Mouse IgG2a
VS3-XY345	Mouse Anti-CD44 Recombinant Antibody (clone 4AP2A1)	FC, IHC, IP, IF	Mouse IgG2a
VS3-WK1309	Mouse Anti-CD44 Recombinant Antibody (VS3-WK1309)	WB, ELISA	Mouse IgG

CAT	Product Name	Application	Type
VS-0424-XY53	AbPlus™ Anti-CD44 Magnetic Beads (1M7.8.1)	IP, Protein Purification
VS-0724-YC1364	AbPlus™ Anti-CD44 Magnetic Beads (VS-0724-YC1364)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC28	Rabbit Anti-CD44 Antibody (VS-0924-YC28) - Cancer Stem Cell Marker	IHC, WB, IF	Rabbit IgG

CAT	Product Name	Application	Type
VS-1024-XY97	Mouse Anti-NHP CD44 Recombinant Antibody (clone 156-3C11)	WB, IHC, IF, FC, IP	Mouse IgG2a, kappa

CAT	Product Name	Application	Type
VS-0125-FY25	Human Anti-CD44 (clone RG7356) scFv-Fc Chimera	BI	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY53	CytoStream™ Mouse Anti-CD44 Recombinant Antibody (VS-0225-XY53)	FC	Mouse IgG2b, kappa
VS-0225-XY54	CytoStream™ Rat Anti-CD44 Recombinant Antibody (clone KM114)	FC, IHC, WB, Block, ELISA	Rat IgG1, kappa
VS13-YC165	CytoStream™ Rabbit Anti-CD44 Recombinant Antibody (VS13-YC165)	WB, IHC-P, FC	Rabbit IgG

CAT	Product Name	Application
VS-0325-XY365	Anti-CD44 Immunohistochemistry Kit	IHC
VS-0525-XY1186	Anti-Mouse CD44 Immunohistochemistry Kit	IHC
VS-0525-XY1187	Anti-Human CD44 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-YC87	Recombinant Anti-CD44 Vesicular Antibody, EV Displayed (VS-0425-YC87)	ELISA, FC, Neut, Cell-uptake

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 2 Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment (DrMAB-989) in HPLC

Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment (CAT# DrMAB-989)
Application: FC, Cyt, Stim, PP, Agonist

Figure 2 Anti-Human IGF1R Antibody (TAB-199) in WB

Human Anti-IGF1R Recombinant Antibody (TAB-199) (CAT# TAB-199)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Figure 2 Human Anti-ERBB3 Recombinant Antibody (TAB-189) in ELISA

Human Anti-ERBB3 Recombinant Antibody (TAB-189) (CAT# TAB-189)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 4 Anti-CD22 Antibody (TAB-198) in Flow Cytometry

Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) (CAT# TAB-198)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-Human IL13 Antibody (TAB-219) in ELISA

Anti-Human IL13 Recombinant Antibody (TAB-219) (CAT# TAB-219)
Application: ELISA, Neut, IF, IP, FC, FuncS

Figure 2 Anti-Human MUC5AC Recombinant Antibody (TAB-200) in SEC-HPLC

Anti-Human MUC5AC Recombinant Antibody (TAB-200) (CAT# TAB-200)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 4 Anti-Human IAV HA Recombinant Antibody (TAB-705)-Fc silenced in ELISA

Anti-αvβ3 Integrin Recombinant Antibody (TAB-705) (CAT# TAB-705)
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC

Figure 2 Mouse Anti-EREG Recombinant Antibody (PABL-084) in HPLC

Mouse Anti-EREG Recombinant Antibody (clone 9E5) (CAT# PABL-084)
Application: ELISA, WB, FuncS

Figure 3 Anti-HIV-1 gp120 Antibody (PABL-163) in Dot Blot

Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3bnc117) (CAT# PABL-163)
Application: Neut, ELISA, FuncS

Figure 2 Anti-Recombinant BTN3A1 Antibody (PABL-415) in ELISA

Mouse Anti-BTN3A1 Recombinant Antibody (clone 103.2) (CAT# PABL-415)
Application: FuncS

Figure 2 Recombinant Anti-VEEV E2 Antibody (PABL-742) in HPLC

Recombinant Human Anti-VEEV E2 Antibody (3B4C-4) (CAT# PABL-742)
Application: Neut

Figure 3 Anti-Human CD34 Recombinant Antibody (TAB-150LC) in ELISA

Human Anti-CD34 Recombinant Antibody (TAB-150LC) (CAT# TAB-150LC)
Application: ELISA

Figure 2 Anti-Mouse F11 Recombinant Antibody (TAB-020WM) in HPLC

Mouse Anti-F11 Recombinant Antibody (TAB-020WM) (CAT# TAB-020WM)
Application: WB

Figure 4 Anti-Influenza A Virus HA Recombinant Antibody (MRO-248LC) in DB

Anti-Influenza A Virus (H1N1/H2N2) HA Recombinant Antibody (C179) (CAT# MRO-248LC)
Application: ELISA

Figure 2 Anti-Human ANGPT2 Recombinant Antibody (TAB-0871CLV) in ELISA

Human Anti-ANGPT2 Recombinant Antibody (TAB-0871CLV) (CAT# TAB-0871CLV)
Application: SPR, Inhib, FuncS

Figure 1 Human Anti-ROR1 Recombinant Antibody (HPAB-0181-LSX) in SDS-PAGE

Human Anti-ROR1 Recombinant Antibody (HPAB-0181-LSX) (CAT# HPAB-0181-LSX)
Application: ELISA, FC, IF, IHC, WB

Figure 2 Recombinant Human Anti-C. botulinum A str. Hall botA Antibody (S25 chimera) (EPAF-0119CQ) in WB

Recombinant Human Anti-C. botulinum A str. Hall botA Antibody (S25 chimera) (CAT# EPAF-0119CQ)
Application: ELISA, Neut

Figure 5 Rabbit Anti-T7 RNA Polymerase Antibody, HRP (MOB-0296MC-HRP) in Dot Blot

Rabbit Anti-T7 RNA Polymerase Antibody (CAT# MOB-0296MC)
Application: ELISA, WB

Figure 2 Mouse Anti-Id Recombinant Antibody (FAMAB-0073-CN) in HPLC

Mouse Anti-Id Recombinant Antibody (clone 1A7) (CAT# FAMAB-0073-CN)
Application: ELISA, FC, RIA

Figure 3 Mouse Anti-Fibrin β chain Antibody (MOB-195YJL) in DB

Mouse Anti-Fibrin β chain Recombinant Antibody (MOB-195YJL) (CAT# MOB-195YJL)
Application: ELISA

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.