Anti-CD44 Recombinant Antibody (Bivatuzumab) (CAT#: TAB-727)
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. Bivatuzumab is a humanized monoclonal antibody against CD44 v6. It has been chemically linked to various radioisotopes for use in radiotherapy for, e.g. inoperable recurrent or metastatic head and neck cancer. It has also been linked to a cytotoxic drug mertansine to form bivatuzumab mertansine.
Specific Inquiry
ELISA
Figure 2 Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA.
Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A) or by 186Re radioactivity measurement in serum (B). Individual data points are depicted after administration of 50 mg of BIWA 4 labeled with 31.9–108.2 mCi of 186Re to 20 HNSCC patients.
Börjesson, P. K., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A., Van Schie, M. H.,... & Van Dongen, G. A. (2003). Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clinical Cancer Research, 9(10), 3961s-3972s.
ELISA
Figure 3 Blood clearance curves of 186Re-BIWA 4 for patients who received the conjugate twice.
Blood clearance was assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A–C) or by 186Re activity measurement in serum (D–F), after the first (▵) and second (○) administration of 186Re-BIWA 4 to patients 11 (A and D), 12 (B and E), and 14 (C and F).
Börjesson, P. K., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A., Van Schie, M. H.,... & Van Dongen, G. A. (2003). Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clinical Cancer Research, 9(10), 3961s-3972s.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ
- CAS
- 214599-60-1
- Generic Name
- bivatuzumab
- Related Disease
- Squamous cancers
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- At -20°C for one year.
Applications
- Application Notes
- The CD44 antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ.
Target
- Alternative Names
- bivatuzumab;214599-60-1;BIWA 4;CD44;CD44 molecule (Indian blood group);CD44 antigen (homing function and Indian blood group system) , MDU2, MDU3, MIC4;CD44 antigen;CD44R;chondroitin sulfate proteoglycan 8;CSPG8;HCELL;hematopoietic cell E and L selectin li
- Gene ID
- 960
- UniProt ID
- P16070
Related Resources
Please refer to Bivatuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Bivatuzumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Bivatuzumab"
Afuco™ Anti-CD44 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-727)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. It is a humanized monoclonal antibody against CD44 v6.
DrugMonitor™ Anti-Bivatuzumab Antibody (VS-1224-YC205)Bivatuzumab (formerly BIWA 4) is a humanized monoclonal antibody against CD44 v6. The DrugMonitor™ Anti-Bivatuzumab Antibody (VS-1224-YC205) is an anti-drug antibody (ADA) against Bivatuzumab. This drug-based antibody is raised in mice immunized with the Bivatuzumab. The anti-Bivatuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Bivatuzumab in samples.
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-236LC | Anti-Human CD44 Recombinant Antibody (huPTA-4621) | FuncS | Humanized antibody |
| TAB-236LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) | FC | Humanized antibody |
| TAB-236LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) | FC | Humanized antibody |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-727, RRID: AB_3111994)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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