Human Anti-CD44 (clone RG7356) scFv-Fc Chimera (CAT#: VS-0125-FY25)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• RG7356

• Applications
• Bioimaging

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The potential function of anti-CD44 scFv-Fc lies in its ability to selectively target and visualize CD44-positive tumor cells. Given that CD44 is a glycoprotein frequently overexpressed in various cancers and cancer stem cells, this targeting could facilitate the imaging of these malignancies. Additionally, the interaction of CD44 with hyaluronic acid (HA) has implications for the activation of several cell signaling pathways that may contribute to enhanced cell proliferation, survival, and invasion. Thus, targeting CD44 presents a promising strategy for cancer therapy.

• Alternative Names
• CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; CD44 Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3

• Gene ID
• 960

• UniProt ID
• P16070

• Cellular Localization
• Cell membrane, Cell projection, Membrane

• Post Translation Modifications
• Proteolytically cleaved in the extracellular matrix by specific proteinases in several cell lines and tumors.
  N-glycosylated.
  O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

• Protein Refseq
• NP_000601.3; NP_001001389.1; NP_001001390.1

• Function
• Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment.
  Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection.
  Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases.
  Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• VS-1024-FY41
• Anti-CD44 (clone RG7356) Recombinant Antibody Coupled Liposome (VS-1024-FY41)

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