Anti-Human CD44 Recombinant Antibody (huPTA-4621) (CAT#: TAB-236LC)

Recombinant monoclonal antibody to CD44. huPTA-4621 is a humanized antibody that can be potentially used in the treatment of head and neck squamous cell carcinoma (HNSCC).

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FuncS

Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.

Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.

Data points represent the mean +/- SEM.

FuncS

Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.

Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.

The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.

Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.

The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.

FuncS

Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.

Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.

FuncS

Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.

Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • huPTA-4621
  • Applications
  • FuncS
  • Related Disease
  • Head and neck squamous cell carcinoma (HNSCC)

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay.

Target

  • Alternative Names
  • IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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