Anti-Human CD44 Recombinant Antibody (huPTA-4621) (CAT#: TAB-236LC)
Recombinant monoclonal antibody to CD44. huPTA-4621 is a humanized antibody that can be potentially used in the treatment of head and neck squamous cell carcinoma (HNSCC).
Specific Inquiry
FuncS
Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.
Data points represent the mean +/- SEM.
FuncS
Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.
The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
FuncS
Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.
The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
FuncS
Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.
FuncS
Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- huPTA-4621
- Applications
- FuncS
- Related Disease
- Head and neck squamous cell carcinoma (HNSCC)
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44
- Gene ID
- 960
- UniProt ID
- P16070
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
Human Antibody
Chimeric Antibody
Mouse Antibody
Chicken IgY Antibody
Blocking Antibody
Neutralizing Antibody
Rabbit Monoclonal Antibody
Fab Fragment Antibody
scFv Fragment Antibody
Recombinant Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-727 | Anti-CD44 Recombinant Antibody (Bivatuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
| TAB-236LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) | FC | Humanized antibody |
| TAB-236LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) | FC | Humanized antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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