Recombinant monoclonal antibody to CD44. huPTA-4621 is a humanized antibody that can be potentially used in the treatment of head and neck squamous cell carcinoma (HNSCC).
Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.
Data points represent the mean +/- SEM.
Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.
The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.
The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.
Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
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CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-991 | Mouse Anti-CD44 Recombinant Antibody (clone BU52) | IHC, WB, IP, Inhib, Stim | Mouse IgG1 F(ab')2, κ |
HPAB-0563-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 1A9); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0564-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 2D1); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0565-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 14G9); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0566-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 10C8); Fab Fragment | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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