Anti-CD70 monoclonal antibody (MDX-1411) (CAT#: Gly-008CL)

MDX-1411, a fully human Ab with enhanced antibody effector function that targets CD70, a member of the TNF family that is highly expressed on multiple cancers, including renal cell carcinoma, lymphoma and glioblastoma. CD70 expression on activated lymphocytes may also be implicated in autoimmune diseases.


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ELISA

Figure 1 Anti-CD70 Antibody (GLY-008CL) in ELISA

ELISA analysis of GLY-008CL was performed by coating with Recombinant Human CD70 Protein (His Tag). Then blocked with BSA and incubated with Anti-Human CD70 Antibody (GLY-008CL). The HRP-conjugated goat anti-Human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.


Specifications

  • Type
  • Fully human Ab
  • Class
  • Antineoplastics; Monoclonal antibodies
  • Mechanism of action
  • Immunostimulants

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Recombinant Antibody

CAT Product Name Application Type
MOB-1584z Mouse Anti-CD70 Recombinant Antibody (clone 24B8) FC, IF, IHC, IP Mouse IgG1, κ
MOB-1639MZ Recombinant Mouse Anti-Human CD70 Antibody (clone CV70) ELISA, FC, FuncS, IHC-Fr, IP Mouse antibody
HPAB-0101-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0101-LSX) ELISA, Inhib, ADCC, ADCP, CDC, FuncS Human IgG
HPAB-0102-LSX Human Anti-CD70 Recombinant Antibody (HPAB-0102-LSX) ELISA, FuncS Human IgG
MOB-072LC Human Anti-CD70 Recombinant Antibody (MOB-072LC) ELISA, FC, FuncS Human IgG

Humanized Antibody

CAT Product Name Application Type
TAB-H76 Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa
TAB-882 Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa
TAB-335LC Human Anti-CD70 Recombinant Antibody (TAB-335LC) ELISA Humanized IgG1, κ
TAB-342LC Human Anti-CD70 Recombinant Antibody (TAB-342LC) FC Humanized IgG
TAB-343LC Human Anti-CD70 Recombinant Antibody (TAB-343LC) FC Humanized IgG

Human Antibody

CAT Product Name Application Type
TAB-336LC-F(E) Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VLVH) FC, ELISA Human antibody
TAB-337LC-F(E) Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VHVL) FC, ELISA Human antibody
TAB-338LC-F(E) Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-5-VH) FC, ELISA Human antibody
TAB-339LC-F(E) Anti-Human CD70 Recombinant Antibody Fab Fragment (VH-5-VL) FC, ELISA Human antibody
TAB-340LC-F(E) Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-8-VH) FC, ELISA Human antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-403CQ Rat Anti-Cd70 Recombinant Antibody (clone 9G24) ELISA, Neut Rat IgG1
NEUT-405CQ Rat Anti-Cd70 Recombinant Antibody (clone CBL684) ELISA, Neut Rat IgG1
NEUT-406CQ Rat Anti-Cd70 Recombinant Antibody (clone FR70) FC, FuncS, Neut, IP Rat IgG2b, κ
NEUT-407CQ Rat Anti-Cd70 Recombinant Antibody (clone CBL856) ELISA, Neut Rat IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-404CQ Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) Block, FC, Inhib, IP Rat IgG2

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0095-LSX-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0095-LSX-S(P)) ELISA, FC Human scFv
HPAB-0096-LSX-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0096-LSX-S(P)) ELISA, FC Human scFv
HPAB-0097-LSX-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0097-LSX-S(P)) ELISA, FC Human scFv
HPAB-0098-LSX-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0098-LSX-S(P)) ELISA, FC Human scFv
HPAB-M0487-YC-S(P) Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); scFv Fragment FC Rat scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H76 Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-AP584-YC-F(E) Mouse Anti-CD70 Recombinant Antibody (clone m1F6); Fab Fragment FC, ADCC, CDC, FuncS Mouse Fab
HPAB-AP585-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone c1F6); Fab Fragment FC, ADCC, CDC, FuncS Chimeric (mouse/human) Fab
HPAB-AP586-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); Fab Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) Fab
HPAB-AP587-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); Fab Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) Fab
HPAB-AP588-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); Fab Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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