Anti-CD70 monoclonal antibody (MDX-1411) (CAT#: Gly-008CL)

MDX-1411, a fully human Ab with enhanced antibody effector function that targets CD70, a member of the TNF family that is highly expressed on multiple cancers, including renal cell carcinoma, lymphoma and glioblastoma. CD70 expression on activated lymphocytes may also be implicated in autoimmune diseases.


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ELISA

Figure 1 Anti-CD70 Antibody (GLY-008CL) in ELISA

ELISA analysis of GLY-008CL was performed by coating with Recombinant Human CD70 Protein (His Tag). Then blocked with BSA and incubated with Anti-Human CD70 Antibody (GLY-008CL). The HRP-conjugated goat anti-Human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.


Specifications

  • Type
  • Fully human Ab
  • Class
  • Antineoplastics; Monoclonal antibodies
  • Mechanism of action
  • Immunostimulants

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Recombinant Antibody

CAT Product Name Application Type
MOB-1584z Mouse Anti-CD70 Recombinant Antibody (clone 24B8) FC, IF, IHC, IP Mouse IgG1, κ
FN-046CQ Mouse Anti-CD70 Recombinant Antibody (clone BU69) ELISA, FC, Block, ICC, IHC Mouse IgG1
HPAB-0468-WJ Human Anti-CD70 Recombinant Antibody (HPAB-0468-WJ) ELISA Human IgG
HPAB-0469-WJ Human Anti-CD70 Recombinant Antibody (HPAB-0469-WJ) ELISA Human IgG
HPAB-0470-WJ Human Anti-CD70 Recombinant Antibody (HPAB-0470-WJ) ELISA Human IgG

Humanized Antibody

CAT Product Name Application Type
TAB-335LC Human Anti-CD70 Recombinant Antibody (TAB-335LC) ELISA Humanized IgG1, κ
TAB-342LC Human Anti-CD70 Recombinant Antibody (TAB-342LC) FC Humanized IgG
TAB-343LC Human Anti-CD70 Recombinant Antibody (TAB-343LC) FC Humanized IgG
TAB-344LC Human Anti-CD70 Recombinant Antibody (TAB-344LC) FC, FuncS Humanized antibody
TAB-342LC-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-342LC-S(P)) FC Humanized scFv

Human Antibody

CAT Product Name Application Type
TAB-336LC-S(P) Anti-Human CD70 Recombinant Antibody scFv Fragment (Mb VLVH) FC, ELISA Human antibody
TAB-337LC-S(P) Anti-Human CD70 Recombinant Antibody scFv Fragment (Mb VHVL) FC, ELISA Human antibody
TAB-338LC-S(P) Anti-Human CD70 Recombinant Antibody scFv Fragment (VL-5-VH) FC, ELISA Human antibody
TAB-339LC-S(P) Anti-Human CD70 Recombinant Antibody scFv Fragment (VH-5-VL) FC, ELISA Human antibody
TAB-340LC-S(P) Anti-Human CD70 Recombinant Antibody scFv Fragment (VL-8-VH) FC, ELISA Human antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-403CQ Rat Anti-Cd70 Recombinant Antibody (clone 9G24) ELISA, Neut Rat IgG1
NEUT-405CQ Rat Anti-Cd70 Recombinant Antibody (clone CBL684) ELISA, Neut Rat IgG1
NEUT-406CQ Rat Anti-Cd70 Recombinant Antibody (clone FR70) FC, FuncS, Neut, IP Rat IgG2b, κ
NEUT-407CQ Rat Anti-Cd70 Recombinant Antibody (clone CBL856) ELISA, Neut Rat IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-404CQ Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) Block, FC, Inhib, IP Rat IgG2

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H76 Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0468-WJ-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0468-WJ-S(P)) ELISA Human scFv
HPAB-0469-WJ-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0469-WJ-S(P)) ELISA Human scFv
HPAB-0470-WJ-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0470-WJ-S(P)) ELISA Human scFv
HPAB-0471-WJ-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0471-WJ-S(P)) ELISA Human scFv
HPAB-0472-WJ-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0472-WJ-S(P)) ELISA Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-AP584-YC-F(E) Mouse Anti-CD70 Recombinant Antibody (clone m1F6); Fab Fragment FC, ADCC, CDC, FuncS Mouse Fab
HPAB-AP585-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone c1F6); Fab Fragment FC, ADCC, CDC, FuncS Chimeric (mouse/human) Fab
HPAB-AP586-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); Fab Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) Fab
HPAB-AP587-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); Fab Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) Fab
HPAB-AP588-YC-F(E) Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); Fab Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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