Anti-CD70 monoclonal antibody (MDX-1411) (CAT#: Gly-008CL)
MDX-1411, a fully human Ab with enhanced antibody effector function that targets CD70, a member of the TNF family that is highly expressed on multiple cancers, including renal cell carcinoma, lymphoma and glioblastoma. CD70 expression on activated lymphocytes may also be implicated in autoimmune diseases.
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ELISA
Figure 1 Anti-CD70 Antibody (GLY-008CL) in ELISA
ELISA analysis of GLY-008CL was performed by coating with Recombinant Human CD70 Protein (His Tag). Then blocked with BSA and incubated with Anti-Human CD70 Antibody (GLY-008CL). The HRP-conjugated goat anti-Human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
Specifications
- Type
- Fully human Ab
- Class
- Antineoplastics; Monoclonal antibodies
- Mechanism of action
- Immunostimulants
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Recombinant Antibody
| CAT | Product Name | Application | Type |
| MOB-1584z | Mouse Anti-CD70 Recombinant Antibody (clone 24B8) | FC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-1639MZ | Recombinant Mouse Anti-Human CD70 Antibody (clone CV70) | ELISA, FC, FuncS, IHC-Fr, IP | Mouse antibody |
| HPAB-0101-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0101-LSX) | ELISA, Inhib, ADCC, ADCP, CDC, FuncS | Human IgG |
| HPAB-0102-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0102-LSX) | ELISA, FuncS | Human IgG |
| MOB-072LC | Human Anti-CD70 Recombinant Antibody (MOB-072LC) | ELISA, FC, FuncS | Human IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-H76 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-882 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
| TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
| TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
Human Antibody
| CAT | Product Name | Application | Type |
| TAB-336LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VLVH) | FC, ELISA | Human antibody |
| TAB-337LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VHVL) | FC, ELISA | Human antibody |
| TAB-338LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-5-VH) | FC, ELISA | Human antibody |
| TAB-339LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VH-5-VL) | FC, ELISA | Human antibody |
| TAB-340LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-8-VH) | FC, ELISA | Human antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0095-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0095-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0096-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0096-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0097-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0097-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0098-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0098-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0487-YC-S(P) | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); scFv Fragment | FC | Rat scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-AP584-YC-F(E) | Mouse Anti-CD70 Recombinant Antibody (clone m1F6); Fab Fragment | FC, ADCC, CDC, FuncS | Mouse Fab |
| HPAB-AP585-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone c1F6); Fab Fragment | FC, ADCC, CDC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-AP586-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
| HPAB-AP587-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
| HPAB-AP588-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
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* Abbreviations
AgonistAgonist
BABioassay
InhibInhibition
PGProteogenomics
StimStimulation
WBWestern Blot
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