Anti-CD70 monoclonal antibody (MDX-1411) (CAT#: Gly-008CL)

MDX-1411, a fully human Ab with enhanced antibody effector function that targets CD70, a member of the TNF family that is highly expressed on multiple cancers, including renal cell carcinoma, lymphoma and glioblastoma. CD70 expression on activated lymphocytes may also be implicated in autoimmune diseases.

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ELISA

Figure 1 Anti-CD70 Antibody (GLY-008CL) in ELISA

ELISA analysis of GLY-008CL was performed by coating with Recombinant Human CD70 Protein (His Tag). Then blocked with BSA and incubated with Anti-Human CD70 Antibody (GLY-008CL). The HRP-conjugated goat anti-Human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.


Specifications

  • Type
  • Fully human Ab
  • Class
  • Antineoplastics; Monoclonal antibodies
  • Mechanism of action
  • Immunostimulants

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Single-domain Antibody

CAT Product Name Application Type
PNBL-012 Recombinant Anti-Human CD70 VHH Single Domain Antibody (27B3) WB, FuncS Llama VHH

Human Antibody

CAT Product Name Application Type
TAB-336LC Anti-Human CD70 Recombinant Antibody (Mb VLVH) ELISA, FC, WB Human antibody
TAB-337LC Anti-Human CD70 Recombinant Antibody (Mb VHVL) ELISA, FC, WB Human antibody
TAB-338LC Anti-Human CD70 Recombinant Antibody (VL-5-VH) FC, WB Human antibody
TAB-339LC Anti-Human CD70 Recombinant Antibody (VH-5-VL) FC, WB Human antibody
TAB-340LC Anti-Human CD70 Recombinant Antibody (VL-8-VH) FC, WB Human antibody

Humanized Antibody

CAT Product Name Application Type
TAB-335LC-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-335LC-S(P)) ELISA Humanized scFv
TAB-342LC-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-342LC-S(P)) FC Humanized scFv
TAB-343LC-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-343LC-S(P)) FC Humanized scFv
TAB-344LC-S(P) Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-344LC-S(P)) FC Human scFv
TAB-335LC-F(E) Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-335LC-F(E)) ELISA Humanized Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-1639MZ Recombinant Mouse Anti-Human CD70 Antibody (clone CV70) ELISA, FC, FuncS, IHC-Fr, IP Mouse antibody
HPAB-AP584-YC Mouse Anti-CD70 Recombinant Antibody (clone m1F6) FC, ADCC, CDC, FuncS Mouse IgG
HPAB-AP585-YC Human Anti-CD70 Recombinant Antibody (clone c1F6) FC, ADCC, CDC, FuncS Chimeric (mouse/human) IgG
HPAB-AP586-YC Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA) FC, ADCC, CDC, FuncS Humanized (mouse/human) IgG
HPAB-AP587-YC Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA) FC, ADCC, CDC, FuncS Humanized (mouse/human) IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-403CQ Rat Anti-Cd70 Recombinant Antibody (clone 9G24) ELISA, Neut Rat IgG1
NEUT-405CQ Rat Anti-Cd70 Recombinant Antibody (clone CBL684) ELISA, Neut Rat IgG1
NEUT-406CQ Rat Anti-Cd70 Recombinant Antibody (clone FR70) FC, FuncS, Neut, IP Rat IgG2b, κ
NEUT-407CQ Rat Anti-Cd70 Recombinant Antibody (clone CBL856) ELISA, Neut Rat IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-404CQ Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) Block, FC, Inhib, IP Rat IgG2

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0095-LSX-F(E) Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0095-LSX-F(E)) ELISA, FC Human Fab
HPAB-0096-LSX-F(E) Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0096-LSX-F(E)) ELISA, FC Human Fab
HPAB-0097-LSX-F(E) Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0097-LSX-F(E)) ELISA, FC Human Fab
HPAB-0098-LSX-F(E) Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0098-LSX-F(E)) ELISA, FC Human Fab
HPAB-M0487-YC-F(E) Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); Fab Fragment FC Rat Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-M0487-YC-S(P) Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); scFv Fragment FC Rat scFv
HPAB-AP584-YC-S(P) Mouse Anti-CD70 Recombinant Antibody (clone m1F6); scFv Fragment FC, ADCC, CDC, FuncS Mouse scFv
HPAB-AP585-YC-S(P) Mouse Anti-CD70 Recombinant Antibody (clone c1F6); scFv Fragment FC, ADCC, CDC, FuncS Mouse scFv
HPAB-AP586-YC-S(P) Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); scFv Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) scFv
HPAB-AP587-YC-S(P) Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); scFv Fragment FC, ADCC, CDC, FuncS Humanized (mouse/human) scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H76 Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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