Anti-human IL6 Recombinant Antibody (SK2a) (TAB-671LC)

Name: Anti-human IL6 Recombinant Antibody (SK2a) (TAB-671LC)
SKU: TAB-671LC
Rating: 5 (1 reviews)

CAT#: TAB-671LC

Recombinant monoclonal antibody SK2a is a human monoclonal antibody that specifically binds to human IL-6 and can be potentially used in the treatment studies of autoimmune disease.

Published Data Gene Expression

Inhib

Figure 2 is a graph representing the result of an ELISA for confirmation of the ability of the present chimeric antibody to inhibit the binding of IL-6 to human IL-7R.

Inhib

Figure 3 is a graph comparing the abilities of four reshaped human SK2 antibodies to inhibit the binding of IL-6 to IL-6R, with that of an SK2 chimeric antibody and the mouse monoclonal antibody SK3.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg

Normal Tissue Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg

Normal Tissue Figure 4 Urinary bladder

Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg

Normal Tissue Figure 5 Lymph node

Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6

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Specifications

Host Species
Human

Type
Human antibody

Specificity
Human

Clone
SK2a

Applications
Inhib

Related Disease
Autoimmune disease

Applications

Application Notes
This antibody has been reported for use in Inhibition.

Target

Alternative Names
IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor

Gene ID
3569

UniProt ID
B4DVM1

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Related Diseases

Inflammatory Bowel Diseases

Rheumatoid Arthritis

Graft-versus-Host Disease

AGE-RAGE Signaling Pathway in Diabetic Complications

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-671LC.pdf

MSDS

MSDS - TAB-671LC.pdf

COA

Certificate of Analysis Lookup

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TAB-671LC-S(P)	Anti-human IL6 scFv Fragment (SK2a)	ELISA	Human antibody
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CAT	Product Name	Application	Type
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