Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) (CAT#: TAB-678LC)

Figure 1 Competition ELISA analysis of BA001 and Anti-IL-6 Antibodies.

Figure 2 Normalized specific activity of the top 10 hits from BA399 affinity maturation by combinatorial protein synthesis (CPS).

The relative specific activity for each clone is normalized to that of Anti-IL-6 Ab BA399, shown as a horizontal black line.

Figure 3 Inhibition of IL-6/sIL6R induced Stat3 phosphorylation in THP-1 cells by increasing anti-IL-6 Mab concentration.

The data are normalized based on Western blot for total Stat3.

Figure 4 Inhibition of Stat3 phosphorylation in THP-1 cells stimulated by IL-6/sIL-6R by various anti-IL6 Mabs including 003, BA399, BA399-2 and BA399-9 using 100 ng/mL IL-6.

Figure 5 Inhibition of serum amyloid A protein production by HepG2 cells stimulated with human IL-6, sIL-6R and IL-1b, by serial dilutions of anti-IL-6 Mabs CNTO136, BA399, BA399-2, BA399-9 at 24 hours.

Figure 6 Inhibition of IL-6 induced DS-1 cell proliferation at 48 hours by anti-IL-6 Mabs BA001, BA399, BA436, BA802, BA808, BA840, BA848 and BA890.