Anti-human IL6 Recombinant Antibody (IL6gk3-2) (TAB-683LC)

Name: Anti-human IL6 Recombinant Antibody (IL6gk3-2) (TAB-683LC)
SKU: TAB-683LC
Rating: 5 (1 reviews)

CAT#: TAB-683LC

Recombinant monoclonal antibody IL6gk3-2 is a human monoclonal antibody that specifically binds to human IL-6 and can be potentially used in the treatment studies of rheumatoid arthritis.

Published Data Gene Expression

ELISA

Figure 1 The results of ELISA where reactivity of IL6gk3-2scFv from IL-6gk series with a recombinant IL-6, human serum albumin (HSA), AB blood type serum, monocyte chemoattractant protein-1 (MCP-1) and MIP-1α (macrophage inflammatory protein-1α) was measured.

SPR

Figure 2 The results of BIA CORE where a binding affinity of IL6gk3-2 scFv with IL-6 was measured.

FuncS

Figure 3 IL6gk3-2 scFv inhibited IL-6 dependent proliferation response of IL-6 dependent cell line KT-3.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg

Normal Tissue Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg

Normal Tissue Figure 4 Urinary bladder

Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg

Normal Tissue Figure 5 Lymph node

Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6

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Specifications

Host Species
Human

Derivation
Phage display library

Type
Human antibody

Specificity
Human

Clone
IL6gk3-2

Applications
ELISA, SPR, FuncS

Related Disease
Rheumatoid arthritis

Applications

Application Notes
This antibody has been tested for use in Enzyme-Linked Immunosorbent Assay, Surface Plasmon Resonance and Functional Assay.

Target

Alternative Names
IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor

Gene ID
3569

UniProt ID
B4DVM1

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Related Diseases

Inflammatory Bowel Diseases

Rheumatoid Arthritis

Graft-versus-Host Disease

AGE-RAGE Signaling Pathway in Diabetic Complications

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-683LC.pdf

MSDS

MSDS - TAB-683LC.pdf

COA

Certificate of Analysis Lookup

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