Recombinant Human Anti-LewisY Antibody (hu3S193) (CAT#: PABX-003)
Anti-LewisY antibody is a Humanized antibody of IgG3 class that binds to an LewisY. This antibody was highly specific for Ley (no binding to H-type 2 or type 1 antigens) and displayed only minimal cross-reactivity with the Lex trisaccharide.
Specific Inquiry
IHC
Figure 1 Uptake of ⁹ºY-hu3S193 in tumor xenografts.
Analysis of MCF-7 xenograft at 72 h after injection by hematoxylin–eosin staining.
Kelly, M. P., Lee, F. T., Smyth, F. E., Brechbiel, M. W., & Scott, A. M. (2006). Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model. Journal of Nuclear Medicine, 47(4), 716-725.
Inhib
Figure 2 MCF-7 xenograft growth (mm3) in response to single-dose treatment on day 0 with 90Y-hu3S193 (A) or isotype control 90Y-huA33 (B).
Results are expressed as mean ± SD (n = 4–5).
Kelly, M. P., Lee, F. T., Smyth, F. E., Brechbiel, M. W., & Scott, A. M. (2006). Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model. Journal of Nuclear Medicine, 47(4), 716-725.
Specifications
- Immunogen
- Human adenocarcinoma cells
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human LewisY
- Species Reactivity
- Human
- Clone
- hu3S193
- Applications
- WB, IF, FuncS, IHC, Inhib
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The Lewis Y antibody has been reported in applications of Western Blot, Immunofluorescence, Functional Assay, Immunohistochemistry, Inhibition.
Target
- Alternative Names
- Lewis Y; Lewis Y antigen; Lewis-Y; Lewis-Y antigen; Lewis (y) antigen; Lewis (y)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Hu3s193"
See other products for "Lewis Y"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-488CL | Anti-Human Lewis Y Recombinant Antibody (MB 311) | Cyt | Antibody |
| TAB-0015CL | Anti-Lewis Y Recombinant Antibody (MB311) | FC, FuncS | Humanized Antibody |
| TAB-0016CL | Anti-Lewis Y Recombinant Antibody (Hu3s193) | RIA, IHC | Humanized Antibody |
| TAB-0017CL | Anti-Lewis Y Recombinant Antibody (hABL364) | CDC, ADCC, ELISA | Humanized Antibody |
| TAB-0019CL | Human Anti-Lewis Y Recombinant Antibody (TAB-0019CL) | FC, FuncS | Humanized IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0650CL | Anti-Human Lewis Y Recombinant Antibody (3S193) | Cyt, ELISA | |
| TAB-0018CL-S(P) | Anti-Lewis Y Recombinant Antibody scFv Fragment (BR55-2) | FuncS, Inhib | |
| TAB-0018CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (BR55-2) | FuncS, Inhib | |
| PABX-131 | Recombinant Mouse Anti-LewisY Antibody (MBR96) | WB, Neut, FuncS | IgG |
| PABX-131-S (P) | Recombinant Mouse Anti-LewisY Antibody scFv Fragment (MBR96) | WB, Neut, FuncS | scFv |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-044LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-045LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-103LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-003-S (P) | Recombinant Human Anti-LewisY Antibody scFv Fragment (hu3S193) | WB, IF, FuncS | scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5) | ELISA, FC, IHC | Mouse IgG |
| FAMAB-1327CQ | Human Anti-Lewis Y Recombinant Antibody (clone BR96) | IHC, Cyt | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ-F(E) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); Fab Fragment | FC, IHC | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ-S(P) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); scFv Fragment | FC, IHC | Mouse scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABX-003. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.