Recombinant Human Anti-LewisY Antibody (hu3S193) (CAT#: PABX-003)
Anti-LewisY antibody is a Humanized antibody of IgG3 class that binds to an LewisY. This antibody was highly specific for Ley (no binding to H-type 2 or type 1 antigens) and displayed only minimal cross-reactivity with the Lex trisaccharide.
Specific Inquiry
IHC
Figure 1 Uptake of ⁹ºY-hu3S193 in tumor xenografts.
Analysis of MCF-7 xenograft at 72 h after injection by hematoxylin–eosin staining.
Kelly, M. P., Lee, F. T., Smyth, F. E., Brechbiel, M. W., & Scott, A. M. (2006). Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model. Journal of Nuclear Medicine, 47(4), 716-725.
Inhib
Figure 2 MCF-7 xenograft growth (mm3) in response to single-dose treatment on day 0 with 90Y-hu3S193 (A) or isotype control 90Y-huA33 (B).
Results are expressed as mean ± SD (n = 4–5).
Kelly, M. P., Lee, F. T., Smyth, F. E., Brechbiel, M. W., & Scott, A. M. (2006). Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model. Journal of Nuclear Medicine, 47(4), 716-725.
Specifications
- Immunogen
- Human adenocarcinoma cells
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human LewisY
- Species Reactivity
- Human
- Clone
- hu3S193
- Applications
- WB, IF, FuncS, IHC, Inhib
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The Lewis Y antibody has been reported in applications of Western Blot, Immunofluorescence, Functional Assay, Immunohistochemistry, Inhibition.
Target
- Alternative Names
- Lewis Y; Lewis Y antigen; Lewis-Y; Lewis-Y antigen; Lewis (y) antigen; Lewis (y)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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