Mouse Anti-MUC1 Recombinant Antibody (clone 12D10) (CAT#: HPAB-0094-YC)
The provided is an antibody, an antigen-binding fragment thereof or a MUC1-binding molecule, having, for example, 40-fold specificity or more for a cancer-associated structure of MUC1 as compared to that of a normal tissue-associated structure of MUC1.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 shows an experimental result of examination with FACS of whether a MUC1 protein expressed on a cancer cell membrane surface binds to a 12D10 antibody or not.
The graphs show the result of analysis by FACS Aria. The left part indicates the result on a breast cancer cell T-47D, the center part indicates a human lung cancer cultured cell, Calu-3 cell, and the right part indicates the result on a mammary gland epithelial cell 184A which as a control. A dotted line indicates a control IgG, and a solid line indicates the 12D10 antibody. From this result, it was demonstrated that the 12D10 antibody strongly reacts with a breast cancer celland a lung cancer cell, but hardly reacts with a mammary gland epithelial cell
Figure 2 shows a standard curve for quantification of MUC1 by a sandwich immunoassay using the antibody 12D10.
Specifications
- Immunogen
- STn (DT*R)-20-Cys
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human MUC1
- Species Reactivity
- Human
- Clone
- 12D10
- Applications
- ELISA, FC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC
- Gene ID
- 4582
- UniProt ID
- P15941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
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