Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Liposome (VS-1024-FY232)

CAT#: VS-1024-FY232

Anti-MUC1 antibody conjugated liposomes hold significant potential as targeted drug delivery systems in pancreatic cancer research. These liposomes can selectively bind to MUC1, a glycoprotein overexpressed in many pancreatic tumors, enhancing the specificity of therapeutic agents while minimizing off-target effects. By encapsulating chemotherapeutics or imaging agents within these liposomes, researchers may improve the efficacy of treatments and facilitate earlier diagnosis. Ultimately, this targeted approach could lead to more personalized and effective therapies for patients suffering from pancreatic cancer.

Gene Expression
Figure 1 IF staining of human cell line RPTEC TERT1 Figure 2 IHC staining of human stomach Figure 3 IF staining of human cell line A-431 Figure 4 IF staining of human cell line U-2 OS Figure 5 Stomach Figure 6 Colon Figure 7 Kidney Figure 8 Testis Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
Sub Cat Product Name Liposome Name Datasheet  
VS-1124-FY3928 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Adriamycin-encapsulated Liposome (VS-1124-FY3928) Adriamycin-encapsulated liposome
VS-1124-FY3929 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Cationic Liposome (VS-1124-FY3929) Cationic liposome
VS-1124-FY3930 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Gd-SLs Liposome (VS-1124-FY3930) Gd-SLs liposome
VS-1124-FY3931 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Triptolide-loaded Liposome (VS-1124-FY3931) Triptolide-loaded liposome
VS-1124-FY3932 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled PEGylated Liposome (VS-1124-FY3932) PEGylated liposome
VS-1124-FY3933 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Phospholipid Liposome (VS-1124-FY3933) Phospholipid liposome
VS-1124-FY3934 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Magnetofluorescent Liposome (VS-1124-FY3934) Magnetofluorescent liposome
VS-1124-FY3935 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled pH-sensitive Liposome (VS-1124-FY3935) pH-sensitive liposome
VS-1124-FY3936 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Phototoxic Liposome (VS-1124-FY3936) Phototoxic liposome
VS-1124-FY3937 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Targeted Liposome (VS-1124-FY3937) Targeted Liposome
VS-1124-FY3938 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Apt1-Liposome (VS-1124-FY3938) Apt1-liposome
VS-1124-FY3939 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Thermosensitive Liposome (VS-1124-FY3939) Thermosensitive liposome
VS-1124-FY3940 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Clodronate Liposome (VS-1124-FY3940) Clodronate liposome
VS-1124-FY3941 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Galcer Liposome (VS-1124-FY3941) Galcer liposome
VS-1124-FY3942 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled HBsAg-loaded Liposome (VS-1124-FY3942) HBsAg-loaded liposome
VS-1124-FY3943 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled Phospholipid Liposome and Cationic Liposome (VS-1124-FY3943) Phospholipid liposome and Cationic liposome
VS-1124-FY3944 Anti-MUC1 (clone 12D10) Recombinant Antibody Coupled ISMN Liposome (VS-1124-FY3944) ISMN liposome
More Infomation

Specifications

  • Potential Clinical Applications
  • Pancreatic cancer

Product Composition

  • Clone
  • 12D10
  • Antibody Type
  • IgG1
  • Antibody Host
  • Mouse
  • Antibody Reactivity
  • Human
  • Antibody Description
  • This specialized recombinant mouse monoclonal antibody has been developed to specifically bind to the MUC1 protein, which plays a pivotal role in cell signaling and immune response modulation. MUC1 is often overexpressed in various cancers, making it a compelling target for therapeutic and diagnostic applications. By attaching to MUC1, this antibody could facilitate the visualization of tumor cells or potentially serve as a vehicle for targeted drug delivery.

Product Property

  • Storage
  • See in the COA
  • Storage Shelf Time
  • See in the COA

Target Information

  • Target
  • MUC1
  • Introduction
  • This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM
  • Full Name
  • Mucin 1, Cell Surface Associated
  • Cellular Localization
  • Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted
  • Post Translation Modifications
  • Highly glycosylated (N- and O-linked carbohydrates and sialic acid). O-glycosylated to a varying degree on serine and threonine residues within each tandem repeat, ranging from mono- to penta-glycosylation. The average density ranges from about 50% in human milk to over 90% in T47D breast cancer cells. Further sialylation occurs during recycling. Membrane-shed glycoproteins from kidney and breast cancer cells have preferentially sialyated core 1 structures, while secreted forms from the same tissues display mainly core 2 structures. The O-glycosylated content is overlapping in both these tissues with terminal fucose and galactose, 2- and 3-linked galactose, 3- and 3,6-linked GalNAc-ol and 4-linked GlcNAc predominating. Differentially O-glycosylated in breast carcinomas with 3,4-linked GlcNAc. N-glycosylation consists of high-mannose, acidic complex-type and hybrid glycans in the secreted form MUC1/SEC, and neutral complex-type in the transmembrane form, MUC1/TM.
    Proteolytic cleavage in the SEA domain occurs in the endoplasmic reticulum by an autoproteolytic mechanism and requires the full-length SEA domain as well as requiring a Ser, Thr or Cys residue at the P + 1 site. Cleavage at this site also occurs on isoform MUC1/X but not on isoform MUC1/Y. Ectodomain shedding is mediated by ADAM17.
    Dual palmitoylation on cysteine residues in the CQC motif is required for recycling from endosomes back to the plasma membrane.
    Phosphorylated on tyrosines and serine residues in the C-terminal. Phosphorylation on tyrosines in the C-terminal increases the nuclear location of MUC1 and beta-catenin. Phosphorylation by PKC delta induces binding of MUC1 to beta-catenin/CTNNB1 and thus decreases the formation of the beta-catenin/E-cadherin complex. Src-mediated phosphorylation inhibits interaction with GSK3B. Src- and EGFR-mediated phosphorylation on Tyr-1229 increases binding to beta-catenin/CTNNB1. GSK3B-mediated phosphorylation on Ser-1227 decreases this interaction but restores the formation of the beta-cadherin/E-cadherin complex. On T-cell receptor activation, phosphorylated by LCK. PDGFR-mediated phosphorylation increases nuclear colocalization of MUC1CT and CTNNB1.
    The N-terminal sequence has been shown to begin at position 24 or 28.
  • Function
  • The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
    The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
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Datasheet

MSDS

COA

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