Recombinant monoclonal antibody to CD37. Lilotomab is a mouse monoclonal antibody that can be potentially used in the treatment of Non-Hodgkin's lymphoma (NHL).
Figure 1 Toxicity of Lilotomab.
Lack of correlation between RM dose derived by surrogate method and reduction in thrombocyte (A) and neutrophil (B) counts demonstrates that this non–imaging-based method is unfit to predict marrow toxicity for 177Lu-lilotomab satetraxetan therapy.
Blakkisrud, J., Løndalen, A., Dahle, J., Turner, S., Holte, H., Kolstad, A., & Stokke, C. (2017). Red marrow–absorbed dose for non-hodgkin lymphoma patients treated with 177lu-lilotomab satetraxetan, a novel anti-cd37 antibody–radionuclide conjugate. Journal of Nuclear Medicine, 58(1), 55-61.
Figure 2 DNA content and DNA damage in U-2932 and RIVA cells after treatment with 177Lu-lilotomab satetraxetan.
Cells were treated with indicated doses of 177Lu-lilotomab satetraxetan [600 MBq/mg] for 18 hours, washed and fixated. DNA content (FxCycleFarRed) and DNA damage (anti-P-g-H2AX) were assessed by flow cytometry.
Rødland, G. E., Melhus, K., Dahle, J., Syljuåsen, R., & Patzke, S. (2018). Cell Cycle Kinase Inhibitors Potentiate the Effect of 177lu-Lilotomab Satetraxetan in Treatment of Aggressive Diffuse Large B-Cell Lymphoma Cell Lines.
Figure 3 ADCC induction by (A) obinutuzumab and (B) rituximab in Raji 2R cells relative to untreated Raji cells of corresponding mAb exposure.
Statistical significance by 2-tailed t-test where *** p< 0.001 and ** p< 0.01 (N=3).
Marion M. Malenge, Sebastian Patzke, Anne Hansen Ree,… & and Ada H. V. Repetto-Llamazares. 177Lu-lilotomab satetraxetan has the potential to counteract resistance to rituximab and obinutuzumab in non-Hodgkin’s lymphoma.
Figure 4 177Lu-lilotomab satetraxetan and the increase was dependent on the concentration of 177Lu-lilotomab satetraxetan.
Rituximab binding presented as mean ± SD of median fluorescence intensity (MFI) plotted against escalating concentrations of mAbs at 3 and 6 days in Raji 2R and in Raji cells (N=3).
Marion M. Malenge, Sebastian Patzke, Anne Hansen Ree,… & and Ada H. V. Repetto-Llamazares. 177Lu-lilotomab satetraxetan has the potential to counteract resistance to rituximab and obinutuzumab in non-Hodgkin’s lymphoma.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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Afuco™ Anti-CD37 ADCC Recombinant Antibody (Lilotomab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD37. Lilotomab is a mouse monoclonal antibody that can be potentially used in the treatment of Non-Hodgkin's lymphoma (NHL).
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0272CL | Anti-Human CD37 Recombinant Antibody (chHH1.1,) | ELISA, WB | Chimeric (mouse/human) |
TAB-0273CL | Anti-Human CD37 Recombinant Antibody (chHH1.3) | Block | Chimeric (mouse/human) |
TAB-0272CL-S(P) | Anti-Human CD37 Recombinant Antibody scFv Fragment (chHH1.1,) | ELISA, WB | Chimeric (mouse/human) |
TAB-0272CL-F(E) | Anti-Human CD37 Recombinant Antibody Fab Fragment (chHH1.1,) | ELISA, WB | Chimeric (mouse/human) |
TAB-0273CL-F(E) | Anti-Human CD37 Recombinant Antibody Fab Fragment (chHH1.3) | Block | Chimeric (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0159-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0159-FY-S(P)) | Activ, Depletion, FuncS, Inhib | Mouse scFv |
HPAB-0163-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0163-FY-S(P)) | FC, Inhib | Mouse scFv |
HPAB-0164-FY-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0164-FY-S(P)) | FC, Inhib | Mouse scFv |
HPAB-AP033-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone A2); scFv Fragment | FuncS | Human scFv |
HPAB-AP034-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone B2); scFv Fragment | FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
HPAB-0163-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0163-FY-F(E)) | FC, Inhib | Mouse Fab |
HPAB-0164-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0164-FY-F(E)) | FC, Inhib | Mouse Fab |
HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
HPAB-AP034-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone B2); Fab Fragment | FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody (Lilotomab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0901-WJ | Mouse Anti-CD37 Recombinant Antibody (clone HH1) | FC | Human IgG |
FAMAB-1051CQ | Human Anti-CD37 Recombinant Antibody (clone G28-1) | Depletion | Human IgG1 |
FAMAB-1052CQ | Mouse Anti-CD37 Recombinant Antibody (clone WR17) | FC | Mouse IgG2a |
FAMAB-1053CQ | Human Anti-CD37 Recombinant Antibody (clone MB-1) | ICC, IHC-P, WB, FC | Human IgG1 |
ZG-0384F | Mouse Anti-CD37 Recombinant Antibody (ZG-0384F) | IF, ELISA | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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