Anti-FR-S-S-Dox ADC
CAT#: ADC-170LZY
This ADC product is composed of an anti-folate receptor (FR) antibody conjugated via S-S linker to Dox (anti-FR-S-S-Dox). It has demonstrated a response in FR positive tumor treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase II and causing DNA damage.


Specifications
- Antibody Overview
- Anti-folate receptor (FR) Antibody
- Linker
- disulfide ("S-S") linker
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- doxorubicin
- Drug Class/Description
- Class: Doxorubicin
Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
Target
- Introduction
- The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
- Alternative Names
- FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;
- Gene ID
- 2348
- UniProt ID
- A0A024R5H1
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Datasheet
MSDS
COA
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See other products for "FOLR1"
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CAT | Product Name | Application | Type |
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IAB-B029(A) | Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
IAB-B029(G) | Recombinant Anti-human FOLR1 Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
IAB-B029(T) | Recombinant Anti-human FOLR1 Intrabody [Tat] | WB, ICC, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
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TAB-113 | Anti-Human folate receptor 1 Recombinant Antibody (TAB-113) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
TAB-019CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-019CQ) | ELISA, WB, IHC | Human IgG1, κ |
TAB-019CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-019CQ-S(P)) | ELISA, WB, IHC | Human scFv |
TAB-019CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-019CQ-F(E)) | ELISA, WB, IHC | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-016CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-016CQ) | ELISA, FC, WB | Human IgG |
TAB-016CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-016CQ-F(E)) | ELISA, FC, WB | Human Fab |
TAB-382CQ | Anti-Human FOLR1 Recombinant Antibody (TAB-382CQ) | IHC | Human antibody |
TAB-382CQ-S(P) | Anti-Human FOLR1 Recombinant Antibody scFv Fragment (TAB-382CQ-S(P)) | IHC | Human antibody |
TAB-382CQ-F(E) | Anti-Human FOLR1 Recombinant Antibody Fab Fragment (TAB-382CQ-F(E)) | IHC | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-017CQ | Rat Anti-FOLR1 Recombinant Antibody (TAB-017CQ) | ELISA, WB, IHC | Rat IgG1, κ |
TAB-017CQ-S(P) | Rat Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-017CQ-S(P)) | ELISA, WB, IHC | Rat scFv |
TAB-020CQ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-020CQ-S(P)) | ELISA, FC, WB, IHC | Mouse scFv |
TAB-017CQ-F(E) | Rat Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-017CQ-F(E)) | ELISA, WB, IHC | Rat Fab |
TAB-020CQ-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-020CQ-F(E)) | ELISA, FC, WB, IHC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-018CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) | ELISA, WB, IHC | Chimeric (Rat/Human) IgG1, κ |
TAB-018CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) | ELISA, WB, IHC | Human scFv |
TAB-018CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) | ELISA, WB, IHC | Chimeric (Rat/Human) Fab |
CAT | Product Name | Application | Type |
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Gly-029LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
Gly-030LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
Gly-116LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
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Gly-029LC-1 | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
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MOR-1333 | Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0115-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0115-CN) | ELISA, FC, IHC | Mouse IgG2b |
HPAB-0116-CN | Human Anti-FOLR1 Recombinant Antibody (HPAB-0116-CN) | ELISA, FC, IHC | Humanized IgG1 |
HPAB-0117-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0117-CN) | ELISA, FC | Mouse IgG |
HPAB-0080-FY | Human Anti-FOLR1 Recombinant Antibody (HPAB-0080-FY) | FC | Human IgG |
VS3-XY3360 | Rabbit Anti-FOLR1 Recombinant Antibody (clone R03-5I8) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0115-CN-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0115-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
HPAB-0116-CN-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0116-CN-S(P)) | ELISA, FC, IHC | Humanized scFv |
HPAB-0080-FY-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0080-FY-S(P)) | FC | Human scFv |
HPAB-M0094-YC-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-M0094-YC-S(P)) | FuncS | Humanized scFv |
HPAB-N0093-YC-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-N0093-YC-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0117-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0117-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0118-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0118-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0119-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0119-CN-F(E)) | ELISA, FC, IHC, WB | Mouse Fab |
HPAB-0120-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0120-CN-F(E)) | ELISA, FC, IHC, WB | Mouse Fab |
HPAB-0121-CN-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0121-CN-F(E)) | ELISA, FC, IHC, WB | Humanized Fab |
CAT | Product Name | Application | Type |
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AFC-TAB-113 | Afuco™ Anti-FOLR1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-113) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
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MHC-CN0049 | APC-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
MHC-CN0050 | PE-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
MHC-CN0685 | PE-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
MHC-CN0686 | APC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
MHC-CN0687 | FITC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC |
CAT | Product Name | Application | Type |
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VS-0325-FY70 | Human Anti-FOLR1 (clone Farletuzumab) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
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VS-0425-YC262 | Recombinant Anti-FOLR1 Vesicular Antibody, EV Displayed (VS-0425-YC262) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
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VS-0525-XY2606 | Anti-FOLR1 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
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VS-0525-YC13 | Recombinant Anti-FOLR1 Biparatopic Antibody, Asymmetric scFv-Fab | ELISA | Asymmetric scFv-Fab |
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