Anti-FR-S-S-Dox ADC

CAT#: ADC-170LZY

This ADC product is composed of an anti-folate receptor (FR) antibody conjugated via S-S linker to Dox (anti-FR-S-S-Dox). It has demonstrated a response in FR positive tumor treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase II and causing DNA damage.

Gene Expression
Figure 1 IF staining of human cell line HeLa Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)

Specifications

  • Antibody Overview
  • Anti-folate receptor (FR) Antibody
  • Linker
  • disulfide ("S-S") linker
  • Linker Class/Description
  • Class: Chemically cleavable Linker-Disulfide Linker
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • doxorubicin
  • Drug Class/Description
  • Class: Doxorubicin
    Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

Target

  • Introduction
  • The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
  • Alternative Names
  • FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for ADC-170LZY. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "FOLR1"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
IAB-B029(A) Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] PCA, Neut, FuncS scFv-(D-Arg)9
IAB-B029(G) Recombinant Anti-human FOLR1 Intrabody [+36 GFP] WB, Neut, FuncS scFv-(+36GFP)
IAB-B029(T) Recombinant Anti-human FOLR1 Intrabody [Tat] WB, ICC, Neut, FuncS scFv-Tat
CAT Product Name Application Type
TAB-018CQ Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) ELISA, WB, IHC Chimeric (Rat/Human) IgG1, κ
TAB-018CQ-S(P) Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) ELISA, WB, IHC Human scFv
TAB-018CQ-F(E) Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) ELISA, WB, IHC Chimeric (Rat/Human) Fab
CAT Product Name Application Type
Gly-029LC-1 Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody
CAT Product Name Application Type
MOR-1333 Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) WB Rabbit IgG
CAT Product Name Application Type
AFC-TAB-113 Afuco™ Anti-FOLR1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-113) FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
CAT Product Name Application Type
VS-0325-FY70 Human Anti-FOLR1 (clone Farletuzumab) scFv-Fc Chimera ELISA, Inhib Human IgG1, scFv-Fc
CAT Product Name Application Type
VS-0425-YC262 Recombinant Anti-FOLR1 Vesicular Antibody, EV Displayed (VS-0425-YC262) ELISA, FC, Neut, Cell-uptake
CAT Product Name Application Type
VS-0525-XY2606 Anti-FOLR1 Immunohistochemistry Kit IHC
CAT Product Name Application Type
VS-0525-YC13 Recombinant Anti-FOLR1 Biparatopic Antibody, Asymmetric scFv-Fab ELISA Asymmetric scFv-Fab
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare